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Neurotoxic effects of benzophenone-3 : the role of estrogen receptors and retinoid X receptor alpha.

2014/13/N/NZ4/04845

Keywords:

neurotoxicity estrogen receptors retinoid X receptor alpha UV filters benzophenone-3

Descriptors:

  • NZ4_8: Neuroendocrinology
  • NZ7_2: Environment and health risks
  • NZ3_5: Molecular neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Agnieszka Wnuk 

Number of co-investigators in the project: 3

Call: PRELUDIUM 7 - announced on 2014-03-17

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2015-02-26

Project end date (Y-m-d): 2018-02-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Prenatal exposure to benzophenone-3 impairs autophagy, disrupts RXRs/PPARγ signaling and alters epigenetic and post-transcriptional statuses in brain neurons
    Authors:
    Wnuk A, Rzemieniec J, Staroń J, Litwa E, Lasoń W, Bojarski A, Kajta M
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 56, strony: 4820-4837), Wydawca: Springer US
    Status:
    Published
    DOI:
    10.1007/s12035-018-1401-5 - link to the publication
  2. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons
    Authors:
    Wnuk A, Rzemieniec J, Litwa E, Lasoń W, Kajta M
    Academic press:
    The Journal of Steroid Biochemistry and Molecular Biology (rok: 2018, tom: 182, strony: 106-118), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2018.04.016 - link to the publication
  3. Apoptosis Induced by the UV Filter Benzophenone-3 in Mouse Neuronal Cells Is Mediated via Attenuation of Erα/Pparγ and Stimulation of Erβ/Gpr30 Signaling.
    Authors:
    Wnuk A, Rzemieniec J, Lasoń W, Krzeptowski W, Kajta M
    Academic press:
    Molecular Neurobiology (rok: 2018, tom: 55, strony: 2362-2383), Wydawca: Springer US
    Status:
    Published
    DOI:
    10.1007/s12035-017-0480-z - link to the publication
  4. Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells
    Authors:
    Wnuk A, Rzemieniec J, Lasoń W, Krzeptowski W, Kajta M
    Academic press:
    Molecular Neurobiology , Wydawca: Springer US
    Status:
    Accepted for publication
    DOI:
    10.1007/s12035-017-0704-2 - link to the publication
  1. APOPTOTIC AND TOXIC EFFECTS OF BENZOPHENONE-3 (BP-3) IN MOUSE EMBRYONIC NEURONAL CELLS
    Authors:
    Wnuk A, Rzemieniec J, Litwa E, Kajta M
    Conference:
    KONFERENCJA NEUROCHEMICZNA 2015 "Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics" (rok: 2015, ), Wydawca: Termedia Publishing House - Folia Neuropathologica 2015; 53 (4)
    Data:
    konferencja 22-23 październik 2015
    Status:
    Published
  2. Apoptotic and neurotoxic actions of chemical UV filter benzophenone-3: a role of the classical and membrane estrogen receptors
    Authors:
    Wnuk, A.; Rzemieniec, J.; Kajta, M.
    Conference:
    29th Congress of the European-College-of-Neuropsychopharmacology (ECNP) (rok: 2016, ), Wydawca: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
    Data:
    konferencja 17-20.09. 2016
    Status:
    Published
    DOI:
    link to the publication

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