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Neurotoxic effects of benzophenone-3 : the role of estrogen receptors and retinoid X receptor alpha.

2014/13/N/NZ4/04845

Keywords

Descriptors

  • NZ4_8: Neuroendokrynologia
  • NZ7_2: Zagrożenia środowiskowe
  • NZ3_5: Neurobiologia molekularna

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Agnieszka Wnuk

Number of co-investigators in the project: 3

Call

PRELUDIUM 7 – announced on 2014-03-17

Amount awarded
150 000 PLN
Project start date
2015-02-26
Project end date
2018-02-25
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (4)

  1. Prenatal exposure to benzophenone-3 impairs autophagy, disrupts RXRs/PPARγ signaling and alters epigenetic and post-transcriptional statuses in brain neurons

    Authors:
    Wnuk A, Rzemieniec J, Staroń J, Litwa E, Lasoń W, Bojarski A, Kajta M
    Academic press:
    Molecular Neurobiology (year: 2019, volume: 56, pages: 4820-4837), Publisher: Springer US
    Status:
    Published
    DOI:
    10.1007/s12035-018-1401-5 – link to the publication

  2. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons

    Authors:
    Wnuk A, Rzemieniec J, Litwa E, Lasoń W, Kajta M
    Academic press:
    The Journal of Steroid Biochemistry and Molecular Biology (year: 2018, volume: 182, pages: 106-118), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2018.04.016 – link to the publication

  3. Apoptosis Induced by the UV Filter Benzophenone-3 in Mouse Neuronal Cells Is Mediated via Attenuation of Erα/Pparγ and Stimulation of Erβ/Gpr30 Signaling.

    Authors:
    Wnuk A, Rzemieniec J, Lasoń W, Krzeptowski W, Kajta M
    Academic press:
    Molecular Neurobiology (year: 2018, volume: 55, pages: 2362-2383), Publisher: Springer US
    Status:
    Published
    DOI:
    10.1007/s12035-017-0480-z – link to the publication

  4. Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells

    Authors:
    Wnuk A, Rzemieniec J, Lasoń W, Krzeptowski W, Kajta M
    Status:
    Accepted for publication

Articles in post-conference publications (2)

  1. Apoptotic and neurotoxic actions of chemical UV filter benzophenone-3: a role of the classical and membrane estrogen receptors

    Authors:
    Wnuk, A.; Rzemieniec, J.; Kajta, M.
    Conference:
    29th Congress of the European-College-of-Neuropsychopharmacology (ECNP) (year: 2016, pages: S370-S370; Abstract: P.1.I.030), Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
    Date:
    conference 17-20.09. 2016
    Status:
    Published
    DOI:
    link to the publication

  2. APOPTOTIC AND TOXIC EFFECTS OF BENZOPHENONE-3 (BP-3) IN MOUSE EMBRYONIC NEURONAL CELLS

    Authors:
    Wnuk A, Rzemieniec J, Litwa E, Kajta M
    Conference:
    KONFERENCJA NEUROCHEMICZNA 2015 Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics (year: 2015, pages: 435-436), Publisher: Termedia Publishing House - Folia Neuropathologica 2015; 53 (4)
    Date:
    conference 22-23 październik 2015
    Status:
    Published

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