Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Studies on the biological activity of selected aminomethylidenebisphosphonic acids

2014/13/B/NZ4/01105

Keywords:

bisphophonates breast cancers chemotherapy adjuvant anticancer therapy tumor metastases osteoporosis

Descriptors:

  • NZ4_12: Other related subjects
  • NZ5_7: Human disease treatment
  • ST5_16:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Nasulewicz-Goldeman 

Number of co-investigators in the project: 5

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 421 650 PLN

Project start date (Y-m-d): 2015-02-11

Project end date (Y-m-d): 2019-02-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Aromatic bis[aminomethylidenebis(phosphonic)] acids prevent ovariectomy-induced bone loss and suppress osteoclastogenesis in mice
    Authors:
    Anna Nasulewicz-Goldeman, Waldemar Goldeman, Anna Nikodem, Marcin Nowak, Diana Papiernik, Tomasz M. Goszczyński, Joanna Wietrzyk
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 9590-9607), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22179590 - link to the publication
  2. "Antimetastatic activity of aromatic aminomethylidenebisphosphonates in 4T1 mouse breast cancer model"
    Authors:
    Anna Nasulewicz-Goldeman, Waldemar Goldeman, Diana Papiernik, Marcin Nowak, Ewa Mrówczyńska, Joanna Wietrzyk
    Academic press:
    International Journal of Oncology , Wydawca: Spandidos Publications
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Biological effects of aromatic bis[aminomethylidenebis(phosphonic)] acids in osteoclast precursors in vitro
    Authors:
    Anna Nasulewicz-Goldeman, Waldemar Goldeman, Ewa Mrówczyńska, Joanna Wietrzyk
    Academic press:
    Chemical Biology and Drug Design (rok: 2019, tom: 94, strony: 1835-1848), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.13597 - link to the publication
  1. A new bisphosphonate - naphthyl-1,5-diaminobis(methylidenebisphosphonic) acid shows a direct biological effect on MDA-MB-231 human breast carcinoma cells
    Authors:
    Anna Nasulewicz-Goldeman, Waldemar Goldeman, Ewa Zielińska, Joanna Wietrzyk
    Conference:
    15th St. Gallen International Breast Cancer Conference (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja 15-18 marca 2017
    Status:
    Published
    DOI:
    link to the publication
  2. Biological activity of benzene-1,4-bis[aminomethylidene (bisphosphonic)] acid towards J774E macrophages – a model of osteoclasts.
    Authors:
    Nasulewicz-Goldeman A, Goldeman W, Wietrzyk J:
    Conference:
    The Tenth Multidisciplinary Conference on Drug Research, Korytnica (rok: 2016, ), Wydawca: Instytut Farmaceutyczny w Warszawie
    Data:
    konferencja 15-19.05.2016
    Status:
    Published

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