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Information of the project and the call

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Ribosomal T-site as modulator of ribosome activity in changing environmental conditions

2014/13/B/NZ1/00953

Keywords:

ribosome ribosomal proteins protein biosynthesis

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_5: Genetic engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej, Wydział Biologii i Biotechnologii

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Tchórzewski 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 928 460 PLN

Project start date (Y-m-d): 2015-03-05

Project end date (Y-m-d): 2018-09-04

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (10)
  1. Daughters of the budding yeast from old mothers have shorter replicative lifespans but not total lifespans. Are DNA damage and rDNA instability the factors that determine longevity?
    Authors:
    Mateusz Molon, Anita Panek, Eliza Molestak, Marek Skoneczny, Marek Tchorzewski, Maciej Wnuk
    Academic press:
    Cell Cycle (rok: 2018, tom: 17, strony: 1173-1187), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/15384101.2018.1464846 - link to the publication
  2. Functional Analysis of the Ribosomal uL6 Protein of Saccharomyces cerevisiae
    Authors:
    Lidia Borkiewicz, Mateusz Moło, Eliza Molestak, Przemysław Grela, Patrycja Horbowicz-Drozdzal, Leszek Wawiórka and Marek Tchórzewski
    Academic press:
    Cells (rok: 2019, tom: 8, strony: 718), Wydawca: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/cells8070718 - link to the publication
  3. Functional analysis of the uL11 protein impact on translational machinery.
    Authors:
    Leszek Wawiórka, Eliza Molestak, Monika Szajwaj, Barbara Michalec-Wawiórka, Aleksandra Boguszewska, Lidia Borkiewicz, Vladyslava Liudkovska, Joanna Kufel and Marek Tchórzewski
    Academic press:
    Cell Cycle (rok: 2016, tom: 15(8), strony: 1060-1072), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15384101.2016.1154245 - link to the publication
  4. Human ribosomal P1-P2 heterodimer represents an optimal docking site for ricin A chain with a prominent role for P1 C-terminus
    Authors:
    Przemysław Grela, Xiao-Ping Li, Patrycja Horbowicz, Monika Dźwierzyńska, Marek Tchórzewski, Nilgun E. Tumer
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 5608), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-05675-5 - link to the publication
  5. Multiplication of Ribosomal P-Stalk Proteins Contributes to the Fidelity of Translation
    Authors:
    Leszek Wawiórka, Eliza Molestak, Monika Szajwaj, Barbara Michalec-Wawiórka, Mateusz Mołoń, Lidia Borkiewicz, Przemysław Grela, Aleksandra Boguszewska, Marek Tchórzewski
    Academic press:
    Molecular and Cellular Biology (rok: 2017, tom: 37, strony: e00060-17), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/MCB.00060-17 - link to the publication
  6. The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress
    Authors:
    Kamil Deryło, Barbara Michalec-Wawiórkaa, Dawid Krokowski, Leszek Wawiórka, Maria Hatzoglou, Marek Tchórzewski
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (rok: 2018, tom: 1865, strony: 34-47), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.002 - link to the publication
  7. The influence of ricin-mediated rRNA depurination on the translational machinery in vivo - New insight into ricin toxicity
    Authors:
    Monika Szajwaj, Leszek Wawiórka, Eliza Molestak, Barbara Michalec-Wawiórka, Mateusz Mołoń, Iwona Wojda, Marek Tchórzewski
    Academic press:
    Biochimica et Biophysica Acta - Molecular Cell Research (rok: 2019, tom: 1866, strony: 118554), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2019.118554 - link to the publication
  8. The rate of metabolism as a factor determining longevity of the Saccharomyces cerevisiae yeast
    Authors:
    Mateusz Molon, Monika Szajwaj, Marek Tchorzewski, Andrzej Skoczowski, Ewa Niewiadomska, Renata Zadrag-Tecza
    Academic press:
    Age (rok: 2016, tom: 38, strony: 11), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-015-9868-8 - link to the publication
  9. How Ricin Damages the Ribosome
    Authors:
    Przemysław Grela, Monika Szajwaj, Patrycja Horbowicz-Drozdzal and Marek Tchórzewski
    Academic press:
    Toxins (Basel) (rok: 2019, tom: 11, strony: 241), Wydawca: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/toxins11050241 - link to the publication
  10. Molecular behavior of human Mrt4 protein, MRTO4, in stress conditions is regulated by its C-terminal region
    Authors:
    Barbara Michalec-Wawiorka, Leszek Wawiorka, Kamil Derylo, Dawid Krokowski, Aleksandra Boguszewska, Eliza Molestak, Monika Szajwaj, Marek Tchorzewski
    Academic press:
    The International Journal of Biochemistry & Cell Biology (rok: 2015, tom: 69, strony: 233-240), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.018 - link to the publication

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