Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Ribosomal T-site as modulator of ribosome activity in changing environmental conditions

2014/13/B/NZ1/00953

Keywords:

ribosome ribosomal proteins protein biosynthesis

Descriptors:

  • NZ1_1:
  • NZ1_2:
  • NZ1_5:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Tchórzewski 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 928 460 PLN

Project start date (Y-m-d): 2015-03-05

Project end date (Y-m-d): 2018-09-04

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (7)
  1. The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress
    Authors:
    Kamil Deryło, Barbara Michalec-Wawiórkaa, Dawid Krokowski, Leszek Wawiórka, Maria Hatzoglou, Marek Tchórzewski
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (rok: 2018, tom: 1865, strony: 34-47), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.002 - link to the publication
  2. How Ricin Damages the Ribosome
    Authors:
    Przemysław Grela, Monika Szajwaj, Patrycja Horbowicz-Drozdzal and Marek Tchórzewski
    Academic press:
    Toxins (Basel) (rok: 2019, tom: 11, strony: 241), Wydawca: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/toxins11050241 - link to the publication
  3. Multiplication of Ribosomal P-Stalk Proteins Contributes to the Fidelity of Translation
    Authors:
    Leszek Wawiórka, Eliza Molestak, Monika Szajwaj, Barbara Michalec-Wawiórka, Mateusz Mołoń, Lidia Borkiewicz, Przemysław Grela, Aleksandra Boguszewska, Marek Tchórzewski
    Academic press:
    Molecular and Cellular Biology (rok: 2017, tom: 37, strony: e00060-17), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/MCB.00060-17 - link to the publication
  4. The rate of metabolism as a factor determining longevity of the Saccharomyces cerevisiae yeast
    Authors:
    Mateusz Molon, Monika Szajwaj, Marek Tchorzewski, Andrzej Skoczowski, Ewa Niewiadomska, Renata Zadrag-Tecza
    Academic press:
    Age (rok: 2016, tom: 38, strony: 11), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-015-9868-8 - link to the publication
  5. Human ribosomal P1-P2 heterodimer represents an optimal docking site for ricin A chain with a prominent role for P1 C-terminus
    Authors:
    Przemysław Grela, Xiao-Ping Li, Patrycja Horbowicz, Monika Dźwierzyńska, Marek Tchórzewski, Nilgun E. Tumer
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 5608), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-05675-5 - link to the publication
  6. Molecular behavior of human Mrt4 protein, MRTO4, in stress conditions is regulated by its C-terminal region
    Authors:
    Barbara Michalec-Wawiorka, Leszek Wawiorka, Kamil Derylo, Dawid Krokowski, Aleksandra Boguszewska, Eliza Molestak, Monika Szajwaj, Marek Tchorzewski
    Academic press:
    The International Journal of Biochemistry & Cell Biology (rok: 2015, tom: 69, strony: 233-240), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.018 - link to the publication
  7. The influence of ricin-mediated rRNA depurination on the translational machinery in vivo - New insight into ricin toxicity
    Authors:
    Monika Szajwaj, Leszek Wawiórka, Eliza Molestak, Barbara Michalec-Wawiórka, Mateusz Mołoń, Iwona Wojda, Marek Tchórzewski
    Academic press:
    Biochimica et Biophysica Acta - Molecular Cell Research (rok: 2019, tom: 1866, strony: 118554), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2019.118554 - link to the publication

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