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Research on human eosinophils as a potential therapeutic target.

2014/13/N/NZ7/00897

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Marek Rafał Grosicki

Number of co-investigators in the project: 2

Call

PRELUDIUM 7 – announced on 2014-03-17

Amount awarded
149 996 PLN
Project start date
2015-03-17
Project end date
2018-03-16
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Dysk przenośny SeaGate Expansion 4TB. Cost: 499 PLN
  2. System do otrzymywania wody ultraczystej. Cost: 19 710 PLN

Information in the final report

Publication in academic press/journals (1)

  1. In vitro study of histamine and histamine receptor ligands influence on the adhesion of purified human eosinophils to endothelium

    Authors:
    Grosicki Marek, Wójcik Tomasz, Chlopicki Stefan, Kieć-Kononowicz Katarzyna
    Academic press:
    European Journal of Pharmacology (year: 2016, volume: 15, pages: 49-59), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2016.02.061 – link to the publication

Articles in post-conference publications (11)

  1. Pharmacological profiling of the newly synthesized histamine H4 ligands – compounds effect on human eosinophils adhesion to endothelium

    Authors:
    Marek Grosicki, Stefan Chłopicki, Dorota Łażewska, Małgorzata Więcek, Katarzyna Kieć-Kononowicz
    Conference:
    Biogenic Amines and Related Biologically Active Compunds XVIth Conference of the Polish Histamine Research Society (year: 2016, pages: 44), Publisher: Polskie Towarzystwo Badań nad Histaminą
    Date:
    conference 27-29.10.2016
    Status:
    Published

  2. Rola receptorów histaminowych H4 w adhezji eozynofili do komórek śródbłonka

    Authors:
    Marek Grosicki, Stefan Chłopicki, Katarzyna Kieć-Kononowicz
    Conference:
    V Konferencja Doktorantów Collegium Medicum UJ (year: 2015, pages: 54), Publisher: Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego
    Date:
    conference 29-09.05.2015
    Status:
    Published

  3. Leukocytes interaction with endothelial cells – the study of eosinophils adhesion to endothelium

    Authors:
    Marek Grosicki, Katarzyna Kieć-Kononowicz, Stefan Chłopicki
    Conference:
    24th Kraków Conference on endothelium, Wierchomla Mała (VII JCET Seminar) (year: 2016, pages: 13), Publisher: JCET
    Date:
    conference 19-21.06.2016
    Status:
    Published

  4. Histamine H4 receptor ligands – their in vitro study on eosinophils adhesion to endothelium

    Authors:
    Marek Grosicki, Stefan Chłopicki, Dorota Łażewka, Małgorzata Więcek, Katarzyna Kieć-Kononowicz
    Conference:
    VIII Konwersatorium Chemii Medycznej (year: 2016, pages: Brak), Publisher: Polskie Towarzystwo Chemii Medycznej
    Date:
    conference 15-17.09.2016
    Status:
    Published

  5. Histamine in inflammation – the involvement of histamine H4 receptor in human eosinophils adhesion to endothelium

    Authors:
    Marek Grosicki, Stefan Chłopicki, Katarzyna Kieć-Kononowicz
    Conference:
    45th Annual Meeting of the European Histamine Research Society (year: 2016, pages: 50), Publisher: European Histamine Research Society
    Date:
    conference 11-14.05.2016
    Status:
    Published

  6. Pharmacology of eosinophils adhesion to endothelium cells - study of modulatory effects of histamine and histamine receptors ligands

    Authors:
    Marek Grosicki, Tomasz Wójcik, Stefan Chłopicki, Katarzyna Kieć-Kononowicz
    Conference:
    5th meeting of the Paul Ehrlich MedChem Euro-PhD Network (year: 2015, pages: 32), Publisher: Paul Ehrlich MedChem Euro-PhD Network
    Date:
    conference 03-05.07.2015
    Status:
    Published

  7. Histamine in inflammation pharmacological study of histamine receptors ligands on human eosinophils activity

    Authors:
    Marek Grosicki, Stefan Chłopicki, Katarzyna Kieć-Kononowicz
    Conference:
    2nd Central European Biomedical Congress From emerging biochemical strategies to personalized medicine (year: 2016, pages: 112), Publisher: CEBC
    Date:
    conference 15-18.06.2016
    Status:
    Published

  8. Role of histamine in the regulation of eosinophils adhesion to endothelial cell

    Authors:
    Marek Grosicki, Tomasz Wójcik, Stefan Chłopicki, Katarzyna Kieć-Kononowicz
    Conference:
    23rd Kraków Conference on Endothelium, Wierchomla Mała 2015 (6th JCET seminar) (year: 2015, pages: 20), Publisher: JCET
    Date:
    conference 11-14.06.2015
    Status:
    Published

  9. Histamina w procesach zapalnych - rola receptorów histaminowych w procesie adhezji ludzkich eozynofili do śródbłonka naczyniowego

    Authors:
    Marek Grosicki, Stefan Chłopicki, Katarzyna Kieć-Kononowicz
    Conference:
    VI Konferencja Doktorantów Uniwersytetu Jagiellońskiego - Collegium Medicum (year: 2016, pages: 39), Publisher: Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego
    Date:
    conference 23.04.2016
    Status:
    Published

  10. Adhezja ludzkich eozynofili do komórek śródbłonka – innowacyjny model funkcjonalny wykorzystany w badaniach nad nowymi związkami wykazującymi powinowactwo do receptorów H4 histaminowych.

    Authors:
    M. Grosicki, S. Chłopicki, D. Łażewska, M. Więcek, K. Kieć-Kononowicz
    Conference:
    VII Konferencja doktorantów Uniwersytet Jagiellońskiego - Collegim Medicum (year: 2017, pages: 43-44), Publisher: Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego
    Date:
    conference 27.05.2017
    Status:
    Published

  11. Adhesionof human eosinophils to endothelium cells – the study of selective histamine receptors antagonists effects on eosinophils adhesion properties

    Authors:
    M. Grosicki, K. Kieć-Konowicz
    Conference:
    44th Annual Meeting of European Histamine Research Society (year: 2015, pages: 82), Publisher: European Histamine Research Society
    Date:
    conference 06.05-09.05.2015
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Techniques used in pharmacological evaluation of histamine H4 receptor function on native human eosinophils

    Authors:
    Grosicki M., Kieć-Kononowicz K.
    Book:
    Histamine receptors as drug targets (year: 2017, volume: I, pages: 209-232), Publisher: Methods in Pharmacology and Toxicology, Humana press springer
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski