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Mechanism and significance of HSF1 activation in estrogen-induced neoplastic transformation.

2014/13/B/NZ7/02341

Keywords

Descriptors

  • NZ7_16: Inne zagadnienia pokrewne
  • NZ5_3: Patogeneza chorób człowieka
  • NZ3_7: Przekaźnictwo sygnału

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Natalia Vydra

Number of co-investigators in the project: 5

Call

OPUS 7 – announced on 2014-03-17

Amount awarded
697 040 PLN
Project start date
2015-05-18
Project end date
2019-11-17
Project duration
54 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Dejonizator wody.
  2. Mieszadło magnetyczne z funkcją grzania. Cost: 3 000 PLN
  3. Termocykler z gradientem. Cost: 30 000 PLN
  4. Wytwornica lodu.
  5. Zestaw aparatów (mini i midi) do elektroforezy kwasów nukleinowych.. Cost: 5 000 PLN
  6. Zestaw komputerowy z oprogramowaniem (system operacyjny, office, Adobe Photoshop, dysk zewnętrzny). Cost: 8 000 PLN
  7. Łaźnia perełkowa.

Information in the final report

Publication in academic press/journals (3)

  1. 17β-Estradiol Activates HSF1 via MAPK Signaling in ERα-Positive Breast Cancer Cells.

    Authors:
    Vydra N, Janus P, Toma-Jonik A, Stokowy T, Mrowiec K, Korfanty J, Długajczyk A, Wojtaś B, Gielniewski B, Widłak W.
    Academic press:
    Cancers (Basel). (year: 2019, volume: 11, pages: 10), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11101533 – link to the publication

  2. Interplay between HSF1 and p53 signaling pathways in cancer initiation and progression: non-oncogene and oncogene addiction.

    Authors:
    Toma-Jonik A, Vydra N, Janus P, Widłak W.
    Academic press:
    Cell Oncol (year: 2019, volume: 42, pages: 579-589), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s13402-019-00452-0 – link to the publication

  3. Heat Shock Factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells

    Authors:
    Vydra N, Janus P, Kuś P, Stokowy T, Mrowiec K, Toma-Jonik A, Krzywon A, Cortez AJ, Wojtaś B, Gielniewski B, Jaksik R, Kimmel M, Widlak W.
    Status:
    Accepted for publication

Articles in post-conference publications (19)

  1. Transcriptional competence of HSF1 activated by 17 beta-estradiol or heat shock

    Authors:
    Janus P, Vydra N, Stokowy T, Toma-Jonik A, Wojtas B, Gielniewski B, Widlak W.
    Conference:
    The 44th FEBS congress (year: 2019, pages: 358), Publisher: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Date:
    conference 6-11.07.
    Status:
    Published
    DOI:
    link to the publication

  2. Wpływ czynnika stresu termicznego HSF1 na zmiany indukowane przez estrogen w komórkach nabłonkowych piersi.

    Authors:
    Patryk Janus, Agnieszka Toma-Jonik, Tomasz Stokowy, Natalia Vydra, Wiesława Widlak
    Conference:
    Perspektywy w onkologii molekularnej - III Zjazd Centrum Onkologii – Instytutu im. Marii Skłodowskiej – Curie (year: 2018, pages: 54), Publisher: Centrum Onkologii-Instytut im.Marii Skłodowskiej-Curie
    Date:
    conference 5-6 kwietnia
    Status:
    Published
    DOI:
    link to the publication

  3. The elevated level of HSF1 directs human mammary epithelial cells towards mesenchymal phenotype

    Authors:
    Natalia Vydra , Patryk Janus , Agnieszka Toma-Jonik , Ryszard Smolarczyk , Magdalena Głowala-Kosińska , Wiesława Widłak
    Conference:
    22th Gliwice Scientific Meetings (year: 2018, pages: 68), Publisher: Association for the Support of Cancer Research
    Date:
    conference 16-17 listopada
    Status:
    Published
    DOI:
    link to the publication

  4. Czynnik transkrypcyjny HSF1 wspiera przejście nabłonkowo-mezenchymalne komórek MCF10a

    Authors:
    Patryk Janus, Agnieszka Toma-Jonik, Smolarczyk Ryszard, Wiesława Widłak, Natalia Vydra
    Conference:
    V Śląskie Spotkania Naukowe (year: 2018, pages: 28), Publisher: Association for the Support of Cancer Research
    Date:
    conference 25-26 kwietnia
    Status:
    Published
    DOI:
    link to the publication

  5. The HSF1 transcription factor as a component of the ERα-dependent signaling pathway in breast cancer cells

    Authors:
    P. Janus , A. Toma-Jonik, T. Stokowy, J. Korfanty , W. Widlak , N. Vydra
    Conference:
    The 43rd FEBS Congress (year: 2018, pages: 337), Publisher: FEBS
    Date:
    conference 7-12 lipca
    Status:
    Published

  6. Udział ścieżki sygnałowej ERK1/2 w aktywacji czynnika transkrypcyjnego HSF1 w komórkach raka piersi traktowanych 17β-estradiolem

    Authors:
    Natalia Vydra, Patryk Janus, Agnieszka Toma-Jonik, Tomasz Stokowy, Joanna Korfanty, Wiesława Widlak
    Conference:
    V Śląskie Spotkania Naukowe (year: 2018, pages: 27), Publisher: Association for the Support of Cancer Research
    Date:
    conference 25-26 maja
    Status:
    Published
    DOI:
    link to the publication

  7. Contribution of heat shock factor 1 to epithelial-mesenchymal transition in epithelial breast cells

    Authors:
    Vydra N, Janus P, Toma-Jonik A, Smolarczyk R, Glowala-Kosinska M, Mrowiec K, Widlak W.
    Conference:
    The 44th FEBS congress (year: 2019, pages: 366-367), Publisher: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Date:
    conference 6-11.07
    Status:
    Published
    DOI:
    link to the publication

  8. ERalpha-signaling is directly regulated by transription factor HSF1

    Authors:
    Patryk Janus, Agnieszka Toma-Jonik , Tomasz Stokowy, Joanna Korfanty , Bartosz Wojtaś , Bartłomiej Gielniewski, Wiesława Widłak , Natalia Vydra
    Conference:
    22th Gliwice Scientific Meetings (year: 2018, pages: 69), Publisher: Association for the Support of Cancer Research
    Date:
    conference 16-17 listopada
    Status:
    Published
    DOI:
    link to the publication

  9. Involvement of estrogen receptor alpha in HSF1 activation

    Authors:
    Patryk Janus, Agnieszka Toma-Jonik, Wieslawa Widlak, Natalia Vydra
    Conference:
    21th Gliwice Scientific Meetings (year: 2017, pages: 97), Publisher: Association for the Support of Cancer Research
    Date:
    conference 17-18 listopada
    Status:
    Published
    DOI:
    link to the publication

  10. Heat Shock Transcription Factor 1 (HSF1) as a potential regulatory element of estrogen signaling

    Authors:
    Agnieszka Toma-Jonik , Patryk Janus , Tomasz Stokowy , Ryszard Smolarczyk , Natalia Vydra, Wieslawa Widlak
    Conference:
    21th Gliwice Scientific Meetings (year: 2017, pages: 165), Publisher: Association for the Support of Cancer Research
    Date:
    conference 17-18 listopada
    Status:
    Published
    DOI:
    link to the publication

  11. Wpływ czynnika transkrypcyjnego HSF1 na fenotyp komórek piersi

    Authors:
    Natalia Vydra, Agnieszka Toma-Jonik, Patryk Janus, Joanna Korfanty, Wiesława Widłak
    Conference:
    IV Śląskie Spotkania Naukowe (year: 2017, pages: 49), Publisher: Association for the Support of Cancer Research
    Date:
    conference 24-25.03
    Status:
    Published
    DOI:
    link to the publication

  12. Heat Shock transcription Factor 1 (HSF1) as a new regulatory element in estrogen signaling.

    Authors:
    Toma-Jonik A, Stokowy T, Janus P, Vydra N, Widlak
    Conference:
    The 8th International Congress on Stress Proteins in Biology and Medicine, STRESS MANAGEMENT MECHANISMS AND PATHWAYS, (year: 2017, pages: 126), Publisher: Cell Stress Society International
    Date:
    conference 13-17 sierpnia
    Status:
    Published

  13. Heat Shock Factor 1 activation via Estrogen Receptors signaling.

    Authors:
    Janus P, Toma-Jonik A, Smolarz M, Widlak W, Vydra N.
    Conference:
    The 8th International Congress on Stress Proteins in Biology and Medicine, STRESS MANAGEMENT MECHANISMS AND PATHWAYS, (year: 2017, pages: 93), Publisher: Cell Stress Society International
    Date:
    conference 13-17 sierpnia
    Status:
    Published

  14. Mechanism of hsf1 activation by estrogen in human mammary cells

    Authors:
    Natalia Vydra, Agnieszka Toma-Jonik, Joanna Korfanty, Anna Naumowicz, Wiesława Widłak
    Conference:
    Śląskie Spotkania Naukowe (year: 2016, pages: 46), Publisher: Association for the Support of Cancer Research
    Date:
    conference 3-4 czerwca
    Status:
    Published
    DOI:
    link to the publication

  15. Crosstalk between estrogen and HSF1 in human mammary cells

    Authors:
    Natalia Vydra, Agnieszka Toma-Jonik, Tomasz Stokowy, Anna Filipczyk, Anna Naumowicz, Krystyna Klyszcz, Wieslawa Widlak
    Conference:
    19th Gliwice Scientific Meetings (year: 2015, pages: 154), Publisher: Association for the Support of Cancer Research
    Date:
    conference 20-21.11
    Status:
    Published
    DOI:
    link to the publication

  16. The migration efficiency of melanoma and breast cancer cells is not corelated with the level of HSF1 protein expression and phosphorylation

    Authors:
    Agnieszka Toma-Jonik, Joanna Korfanty, Anna Naumowicz, Natalia Vydra, Krystyna Klyszcz, Wieslawa Widlak
    Conference:
    19th Gliwice Scientific Meetings (year: 2015, pages: 152), Publisher: Association for the Support of Cancer Research
    Date:
    conference 20-21 listopada
    Status:
    Published
    DOI:
    link to the publication

  17. Preliminary analysis of transcriptome of the MCF7 cells with HSF1 knockdown after heat shock or estrogen exposure

    Authors:
    Agnieszka Toma-Jonik, Wiesława Widłak, Tomasz Stokowy, Joanna Tobiasz, Natalia Vydra
    Conference:
    2nd Congress BIO 2016 (year: 2016, pages: Session 9: page 86), Publisher: Acta Biochimica Polonica 63, Suppl. 2/2016
    Date:
    conference 13-16 września
    Status:
    Published
    DOI:
    link to the publication

  18. HSF1 contribution to cancer cell phenotype.

    Authors:
    Vydra N, Toma-Jonik A, Korfanty J, Janus P, Widłak W
    Conference:
    20th Gliwice Scientific Meetings (year: 2016, pages: 9), Publisher: Association for the Support of Cancer Research
    Date:
    conference 18-19 listopada
    Status:
    Published
    DOI:
    link to the publication

  19. Czynnik transkrypcyjny HSF1 jako element ścieżki sygnałowej zależnej od ERα w komórkach raka piersi.

    Authors:
    Vydra N, Janus P, Toma-Jonik A, Stokowy T, Smolarczyk R, Korfanty J, Widlak W.
    Conference:
    Perspektywy w onkologii molekularnej - III Zjazd Centrum Onkologii – Instytutu im. Marii Skłodowskiej – Curie (year: 2018, pages: 5), Publisher: Centrum Onkologii-Instytut im.Marii Skłodowskiej-Curie
    Date:
    conference 5-6 kwietnia
    Status:
    Published
    DOI:
    link to the publication

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