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Information on the principal investigator and host institution

Information of the project and the call

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Impaired IGF/insulin signaling in skeletal muscle of transgenic animals SOD1 G93A its effect on iron metabolism.

2014/13/B/NZ7/02346

Keywords:

Iron skeletal muscle p66Shc Akt IGF insulina

Descriptors:

  • NZ3_7: Signal transduction
  • NZ4_11: Metabolism
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Nauk o Zdrowiu z Oddziałem Pielęgniarstwa i Instytutem Medycyny Morskiej i Tropikalnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jędrzej Antosiewicz 

Number of co-investigators in the project: 6

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 594 900 PLN

Project start date (Y-m-d): 2015-02-04

Project end date (Y-m-d): 2019-02-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  1. hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway
    Authors:
    Malgorzata Halon-Golabek, Andzelika Borkowska, Jan J. Kaczor, Wieslaw Ziolkowski, Damian J. Flis, Narcyz Knap, Kajetan Kasperuk, Jedrzej Antosiewicz
    Academic press:
    Journal of Cachexia, Sarcopenia and Muscle (rok: 2018, tom: 9, strony: 557–569), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcsm.12283 - link to the publication
  2. Homocysteine-induced decrease in HUVEC cells' resistance to oxidative stress is mediated by Akt-dependent changes in iron metabolism
    Authors:
    Andzelika Borkowska, Wieslaw Ziolkowski, Katarzyna Kaczor, Anna Herman-Antosiewicz, Narcyz Knap, Agata Wronska, Jedrzej Antosiewicz
    Academic press:
    Eur Journal of Nutrition (rok: 2020, tom: n/a, strony: n/a), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00394-020-02360-8 - link to the publication
  3. Iron Metabolism of the Skeletal Muscle and Neurodegeneration
    Authors:
    Malgorzata Halon-Golabek, Andzelika Borkowska, Anna Herman-Antosiewicz and Jedrzej Antosiewicz
    Academic press:
    Front. Neurosci. 13:165. (rok: 2019, tom: 13, strony: 45306), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnins.2019.00165 - link to the publication

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