Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pessimism as cognitive biomarker of depression in animal model

2014/13/B/NZ4/00214

Keywords:

pessimism optimism cognitive judgement bias behaviour animal model depression

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_1: Etiology of human diseases

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Rafał Ryguła 

Number of co-investigators in the project: 3

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 1 003 748 PLN

Project start date (Y-m-d): 2015-01-27

Project end date (Y-m-d): 2018-12-26

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw kamer video wraz z monitorem niezbędny do nagrań zachowań zwierząt podczas testów przerzutności uwagi i wymuszonego pływania (5 000 PLN)
  2. Zestaw 8 aparatów do warunkowania instrumentalnego szczurów wraz z jednostką sterującą, szokerami i generatorami dźwięku (308 000 PLN)
  3. 2 komputery (jeden dla doktoranta i jeden dla kierownika projektu) (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (10)
  1. Ketamine decreases sensitivity of male rats to misleading negative feedback in a probabilistic reversal-learning task.
    Authors:
    Rychlik M, Bollen E, Rygula R.
    Academic press:
    Psychopharmacology (Berl) (rok: 2017, tom: 234(4), strony: 613-620), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-016-4497-1 - link to the publication
  2. The trait 'pessimism' does not interact with cognitive flexibility but makes rats more vulnerable to stress-induced motivational deficits: Results from the attentional set-shifting task.
    Authors:
    Drozd R, Rojek-Sito K, Rygula R.
    Academic press:
    Behav Brain Res. (rok: 2017, tom: 335, strony: 199-207.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2017.08.028 - link to the publication
  3. Effects of cognitive judgement bias and acute antidepressant treatment on sensitivity to feedback and cognitive flexibility in the rat version of the probabilistic reversal-learning test.
    Authors:
    Robert Drozd, Michal Rychlik, Agata Fijalkowska i Rafal Rygula
    Academic press:
    Behavioural Brain Research (rok: 2019, tom: 1;359, strony: 619-629), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.003 - link to the publication
  4. The effects of pessimism on cell-mediated immunity in rats.
    Authors:
    Curzytek K, Kubera M, Trojan E, Wójcik K, Basta-Kaim A, Detka J, Maes M, Rygula R.
    Academic press:
    Prog Neuropsychopharmacol Biol Psychiatry. (rok: 2018, tom: Jan 3;80(Pt C), strony: 295-303), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2017.04.034 - link to the publication
  5. Cognitive Judgment Bias Interacts with Risk Based Decision Making and Sensitivity to Dopaminergic Challenge in Male Rats
    Authors:
    Drozd R, Cieslak PE, Rychlik M, Rodriguez Parkitna J, Rygula R.
    Academic press:
    Frontiers in Behavioral Neuroscience (rok: 2016, tom: 45527, strony: 0,529861111111111), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnbeh.2016.00163 - link to the publication
  6. Effects of optimism on gambling in the rat slot machine task.
    Authors:
    Rafa Dominik, Kregiel Jakub, Popik Piotr, Rygula Rafal
    Academic press:
    Behavioural Brain Research (rok: 2016, tom: Mar 1;300, strony: 97-105), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1016/j.bbr.2015.12.013. - link to the publication
  7. Trait "pessimism" is associated with increased sensitivity to negative feedback in rats.
    Authors:
    Rafal Rygula and Piotr Popik
    Academic press:
    Cognitive Affective and Behavioural Neuroscience (rok: 2016, tom: brak, strony: wersja online (ahead of print)), Wydawca: Springer
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Motivational and cognitive implication of judgment bias ('optimism'/'pessimism') in rats.
    Authors:
    Rafal Rygula, Jakub Kregiel, Joanna Golebiowska, Michal Rychlik and Robert Drozd
    Conference:
    23rd Annual International Conference on Comparative Cognition (rok: 2016, ), Wydawca: Comparative Cognition Society
    Data:
    konferencja 13-16.04.2016
    Status:
    Published
    DOI:
    link to the publication
  2. TRAIT PESSIMISM DETERMINES VULNERABILITY OF RATS TO THE STRESS INDUCED MOTIVATIONAL DEFICITS – UNEXPECTED RESULTS FROM THE ATTENTIONAL SET SHIFTING TASK
    Authors:
    Robert Drozd, Karolina Rojek and Rafal Rygula
    Conference:
    TRANSLATIONAL NEUROSCIENCE AND MENTAL DISORDERS Bridging the gap between animal models and human condition (rok: 2016, ), Wydawca: INTERNATIONAL SCHOOL OF ETHOLOGY and INTERNATIONAL SCHOOL OF NEUROSCIENCE JOHN ECCLES"
    Data:
    konferencja 4-9.11.2016
    Status:
    Published
  3. Trait pessimism determines vulnerability of rats to the stress induced motivational deficits – unexpected results from the attentional set shifting task.
    Authors:
    Robert Drozd, Karolina Rojek and Rafal Rygula
    Conference:
    4th International Seminar on Behavioural Methods (rok: 2016, ), Wydawca: Center for Experimental Medicine Medical University of Silesia in Katowice
    Data:
    konferencja 08-10.09.2016
    Status:
    Published
    DOI:
    link to the publication
  4. Cognitive judgment bias determines vulnerability of rats to chronic stress and antidepressant treatment
    Authors:
    Rafal Rygula, Michal Rychlik, & Robert Drozd
    Conference:
    25th Annual International Conference on Comparative Cognition (rok: 2018, ), Wydawca: Proceedings of the Conference on Comparative Cognition
    Data:
    konferencja 4-7 Kwiecien 2018
    Status:
    Published
    DOI:
    link to the publication
  5. PESSIMISTIC JUDGMENT BIAS AS A COGNITIVE BIOMARKER IN ANIMAL MODELS OF PSYCHIATRIC DISORDERS
    Authors:
    Rygula Rafal, Golebiowska Joanna, Drozd Robert, Rychlik Michal, Rafa Dominik, Cieslak Przemyslaw, Rodriguez Parkitna Jan, Curzytek Katarzyna, Kubera Marta
    Conference:
    European Behavioural Pharmacology Society Biennial Meeting w Heraklion, Grecja (rok: 2017, ), Wydawca: EBPS
    Data:
    konferencja 31.08.2017 do 03.09.2017
    Status:
    Published
    DOI:
    link to the publication
  6. Behavioural and pharmacological validation of probabilistic reversal learning task in rats
    Authors:
    Michal Rychlik and Rafal Rygula
    Conference:
    NEURONUS 2016 IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus
    Data:
    konferencja 22-24.04.2016
    Status:
    Published
    DOI:
    link to the publication
  7. KETAMINE DECREASES SENSITIVITY OF MALE RATS TO NEGATIVE FEEDBACK IN THE PROBABILISTIC REVERSAL LEARNING TASK
    Authors:
    Michal Rychlik and Rafal Rygula
    Conference:
    TRANSLATIONAL NEUROSCIENCE AND MENTAL DISORDERS Bridging the gap between animal models and human condition (rok: 2016, ), Wydawca: INTERNATIONAL SCHOOL OF ETHOLOGY and INTERNATIONAL SCHOOL OF NEUROSCIENCE JOHN ECCLES"
    Data:
    konferencja 4-9 listopad 2016
    Status:
    Published
  8. Ketamine decreases sensitivity of male rats to negative feedback in a probabilistic reversallearning task
    Authors:
    Michal Rychlik and Rafal Rygula
    Conference:
    4th International Seminar on Behavioural Methods (rok: 2016, ), Wydawca: Center for Experimental Medicine Medical University of Silesia in Katowice
    Data:
    konferencja 08-10.09.2016
    Status:
    Published
    DOI:
    link to the publication
  9. Cognitive and motivational implications of cognitive judgment bias measured in attentional set shifting test in rats
    Authors:
    Karolina Rojek, Robert Drozd and Rafal Rygula
    Conference:
    NEURONUS 2016 IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus
    Data:
    konferencja 22-24.04.2016
    Status:
    Published
    DOI:
    link to the publication
  10. Optimistic rats are willing to risk; a role for dopamine
    Authors:
    Robert Drozd, Przemyslaw Eligiusz Cieslak, Jan Rodriguez Parkitna and Rafal Rygula
    Conference:
    NEURONUS 2016 IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus
    Data:
    konferencja 22-24.04.2016
    Status:
    Published
    DOI:
    link to the publication

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