Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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MECHANISMS AND CONSEQUENCES OF ECTO-ADENOSINE DEAMINASE ACTIVITY IN ATHEROSCLEROSIS

2014/13/N/NZ4/04471

Keywords:

ecto-adenosine deaminase atherosclerosis adenosine inflammation

Descriptors:

  • NZ4_11: Metabolism
  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Barbara Kutryb-Zając 

Number of co-investigators in the project: 2

Call: PRELUDIUM 7 - announced on 2014-03-17

Amount awarded: 148 700 PLN

Project start date (Y-m-d): 2015-04-09

Project end date (Y-m-d): 2018-04-08

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Blok grzejąco chłodzący (14 071 PLN)
  2. Wytrząsarka laboratoryjna (7 500 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Inhibition of LPS-stimulated ecto-adenosine deaminase attenuates endothelial cell activation
    Authors:
    Barbara Kutryb-Zajac, Paulina Mierzejewska, Elzbieta Sucajtys-Szulc, Alicja Bulinska, Magdalena A. Zabielska, Patrycja Jablonska, Marcin Serocki, Patrycja Koszalka, Ryszard Milczarek, Agnieszka Jasztal, Rafal Bartoszewski, Stefan Chlopicki, Ewa M. Slominska, Ryszard T. Smolenski
    Academic press:
    Journal of Molecular and Cellular Cardiology (rok: 2019, tom: 128, strony: 62-76), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.yjmcc.2019.01.004 - link to the publication
  2. Increased Activity of Vascular Adenosine Deaminase in Experimental Atherosclerosis and Therapeutic Potential of its Inhibition
    Authors:
    B. Kutryb-Zajac, L. Mateuszuk, P. Zukowska, A. Jasztal, M.A. Zabielska, M. Toczek, A. Zakrzewska, B. Sitek, E.M. Slominska, S. Chlopicki, R.T. Smolenski
    Academic press:
    Cardiovascular Research (rok: 2016, tom: 112, strony: 590-605), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/cvr/cvw203 - link to the publication
  3. Vascular extracellular adenosine metabolism in mice correlates with susceptibility to atherosclerosis
    Authors:
    Barbara Kutryb-Zajac, Alicja Bulinska, Magdalena A. Zabielska, Paulina Zukowska, Ewa M. Slominska, Ryszard T. Smolenski
    Academic press:
    Nucleosides, Nucleotides and Nucleic Acids (rok: 2018, tom: 37(11), strony: 653-662), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2018.1489051 - link to the publication
  4. The effects of pro- and anti-atherosclerotic factors on intracellular nucleotide concentration in murine endothelial cells
    Authors:
    Barbara Kutryb-Zajac, Patrycja Koszalka, Ewa M. Slominska, Ryszard T. Smolenski
    Academic press:
    Nucleosides, Nucleotides and Nucleic Acids (rok: 2018, tom: 37(11), strony: 645-652), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2018.1498513 - link to the publication

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