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Stearoyl-CoA desaturase and intracellular lipid signaling as novel players in regulation of thyroid hormone action in the heart

2014/13/B/NZ4/00199

Keywords

Descriptors

  • NZ4_2: Fizjologia
  • NZ4_6: Endokrynologia
  • NZ4_11: Metabolizm

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Paweł Dobrzyń

Number of co-investigators in the project: 5

Call

OPUS 7 – announced on 2014-03-17

Amount awarded
949 000 PLN
Project start date
2015-03-13
Project end date
2019-03-12
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (11)

  1. Białkowe czynniki lipogenne - rola w regulacji metabolizmu i funkcji mięśnia sercowego

    Authors:
    T. Bednarski, A. Pyrkowska, A. Opasinska, P. Dobrzyn
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (year: 2016, volume: 70, pages: 644-653), Publisher: Instytut Immunologii i Terapii Doświadczalnej PAN
    Status:
    Published
    DOI:
    10.5604/17322693.1206541 – link to the publication

  2. Stearoyl-CoA desaturase 1 as a therapeutic target for the treatment of cancer

    Authors:
    Z. Tracz-Gaszewska, P. Dobrzyn
    Academic press:
    Cancers (year: 2019, volume: 11, pages: 948), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11070948 – link to the publication

  3. SCD1 regulates the AMPK/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle

    Authors:
    A. Dziewulska A, A.M. Dobosz, A. Dobrzyn, A. Smolinska, K. Kolczynska, J.M. Ntambi, P. Dobrzyn
    Academic press:
    Journal of Cellular Physiology (year: 2020, volume: 1865, pages: 1129-1140), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.29026 – link to the publication

  4. Cardiospecific deletion of αE-catenin leads to heart failure and lethality in mice

    Authors:
    V.V. Balatskyi, L.L. Macewicz, A.M. Gan, S.V. Goncharov, P. Pawelec, G.V. Portnichenko, T.Y. Lapikova-Bryginska, V.O. Navrulin, V.E. Dosenko, A. Olichwier, P. Dobrzyn, O.O. Piven
    Academic press:
    Pflügers Archiv - European Journal of Physiology (year: 2018, volume: 470, pages: 1485-1499), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00424-018-2168-2 – link to the publication

  5. Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and β-catenin binding in pancreatic β-cells

    Authors:
    M. Jazurek-Ciesiolka, J. Janikiewicz, P. Dobrzyn, A. Dziewulska, K. Kozinski, A. Dobrzyn
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (year: 2019, volume: 1865, pages: 2753-2764), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2019.06.018 – link to the publication

  6. The role of stearoyl-CoA desaturase in the regulation of cardiac metabolism

    Authors:
    S. Tabaczar, M. Wołosiewicz, A. Filip, A. Olichwier, P. Dobrzyn
    Academic press:
    Postępy Biochemii (year: 2018, volume: 64, pages: 183-189), Publisher: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_130 – link to the publication

  7. Interplay between thyroid hormones and stearoyl-CoA desaturase 1 in the regulation of lipid metabolism in the heart

    Authors:
    A. Olichwier, V.V. Balatskyi, M. Wolosiewicz, J.M. Ntambi, P. Dobrzyn
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 109), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22010109 – link to the publication

  8. Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic beta-cells

    Authors:
    J. Janikiewicz, K. Hanzelka, A. Dziewulska, K. Kozinski, P. Dobrzyn, T. Bernas, A. Dobrzyn
    Academic press:
    Journal of Lipid Research (year: 2015, volume: 56, pages: 1901-1911), Publisher: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1194/jlr.M059980 – link to the publication

  9. Adipose- and muscle-derived Wnts trigger pancreatic beta-cell adaptation to systemic insulin resistance

    Authors:
    K. Kozinski, M. Jazurek, P. Dobrzyn, J. Janikiewicz, K. Kolczynska, A. Gajda, A. Dobrzyn
    Academic press:
    Scientific Reports (year: 2016, volume: 6, pages: 31553), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/spep31553 – link to the publication

  10. Stearoyl-CoA desaturase 1 deficiency reduces lipid accumulation in the heart by activating lipolysis independently of peroxisome proliferator-activated receptor alpha

    Authors:
    T. Bednarski, A. Olichwier, A. Opasinska, A. Pyrkowska, A.M. Gan, J.M. Ntambi, P. Dobrzyn
    Academic press:
    Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids (year: 2016, volume: 1861, pages: 2029-2037), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbalip.2016.10.005 – link to the publication

  11. Mitochondria and reactive oxygen species in aging and age-related diseases

    Authors:
    C. Giorgi, S. Marchi, I.C.M. Simoes, Z. Ren, G. Morciano, M. Perrone, P. Patalas-Krawczyk, S. Borchard, P. Jędrak, K. Pierzynowska, J. Szymański, D.Q. Wang, P. Portincasa, G. Węgrzyn, H. Zischka, P. Dobrzyn, M. Bonora, J. Duszynski, A. Rimessi, A. Karkucinska-Wieckowska, A. Dobrzyn, G. Szabadkai, B. Zavan, P.J. Oliveira, V.A. Sardao, P. Pinton, M.R. Wieckowski
    Academic press:
    International Review of Cell and Molecular Biology (year: 2018, volume: 340, pages: 209-344), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/bs.ircmb.2018.05.006 – link to the publication

Articles in post-conference publications (11)

  1. Development of hypertension-induced left ventricular hypertrophy is associated with impairment of lipolysis in cardiomyocytes

    Authors:
    T. Bednarski, M. Duda, P. Dobrzyn
    Conference:
    44th European Muscle Conference, Warszawa (year: 2015, pages: 580-581), Publisher: Springer
    Date:
    conference 21-25 wrzesień
    Status:
    Published

  2. Activity of Akt/mTOR pathway depends on type and time of hypertensive stimuli in the heart

    Authors:
    T. Bednarski, M. Duda, P. Dobrzyn
    Conference:
    40th The Federation of European Biochemical Societies Congress, Berlin, Niemcy (year: 2015, pages: 222), Publisher: The Federation of European Biochemical Societies
    Date:
    conference 4-9 lipiec
    Status:
    Published

  3. Functional impact of stearoyl-CoA desaturase 1 deficiency on thyroid hormone signaling

    Authors:
    A. Olichwier, A. Pyrkowska, P. Dobrzyn
    Conference:
    44th European Muscle Conference, Warszawa (year: 2015, pages: 588), Publisher: Springer
    Date:
    conference 21-25 wrzesień
    Status:
    Published

  4. Role of stearoyl-CoA desaturase 1 (SCD1) in the regulation of Akt and ERK1/2 signaling pathways in hyperthyroidic heart

    Authors:
    A. Olichwier, A. Filip, V. Navrulin, P. Dobrzyn
    Conference:
    27th Congress of the Polish Physiological Society (year: 2017, pages: 63), Publisher: Polish Physiological Society
    Date:
    conference 21-22 wrzesień
    Status:
    Published

  5. Regulation of cardiac lipid metabolism by stearoyl-CoA desaturase 4 in hyperthyroidism

    Authors:
    M. Ghanim, A. Olichwier, P. Dobrzyn
    Conference:
    FEBS Advanced Lecture Course on Redox Regulation of Metabolic Processes (year: 2016, pages: 17), Publisher: FEBS
    Date:
    conference 19-25 wrzesień
    Status:
    Published

  6. Lipid metabolism in hyperthyroid heart - the role of stearoyl-CoA desaturase 1

    Authors:
    A. Olichwier, P. Dobrzyn
    Conference:
    The 2016 Obesity Summit (year: 2016, pages: 52), Publisher: EuroSciCon
    Date:
    conference 12-14 kwiecień
    Status:
    Published

  7. Role of stearoyl-CoA desaturase 1 (SCD1) in thyroid hormone mediated regulation of lipid metabolism in the heart

    Authors:
    A. Olichwier, P. Pawelec, P. Dobrzyn
    Conference:
    International Conference on the Bioscenece of Lipids (year: 2017, pages: 75), Publisher: ICBL
    Date:
    conference 10-14 wrzesień
    Status:
    Published

  8. Role of stearoyl-CoA desaturase 1 in regulation of epigenetic modifications via genomic and nongenomic thyroid hormone action in the heart

    Authors:
    A. Olichwier, P. Dobrzyn
    Conference:
    FEBS Advanced Lecture Course on Nuclear Receptors and Epigenomic Mechanisms in Human Disease and Aging (year: 2017, pages: 47), Publisher: FEBS
    Date:
    conference 27 sierpień - 1 wrzesień
    Status:
    Published

  9. Role of stearoyl-CoA desaturase 1 and thyroid hormones in epigenetic regulation in the heart

    Authors:
    A. Olichwier, A.M. Dobosz, M. Ghanim, P. Dobrzyn
    Conference:
    FEBS Workshop on Chromatin Proteomics (year: 2016, pages: 29), Publisher: FEBS
    Date:
    conference 3-8 październik
    Status:
    Published

  10. The role of SCD1 in thyroid hormone dependent control of epigenetic modification in cardiomyocytes

    Authors:
    A. Olichwier, A. Filip, M. Wolosiewicz, P. Dobrzyn
    Conference:
    43rd The Federation of European Biochemical Societies Congress (year: 2018, pages: 137), Publisher: Wiley
    Date:
    conference 7-12 lipiec
    Status:
    Published

  11. Loss of stearoyl-CoA desaturase 1 affects thyroid hormnone action and induces epigenetic modofications in cardiomyocytes

    Authors:
    A. Olichwier, P. Dobrzyn
    Conference:
    42nd Annual Meeting of the European Thyroid Association (year: 2019, pages: 15), Publisher: Karger
    Date:
    conference 7-10 wrzesień
    Status:
    Published

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