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Information of the project and the call

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Stearoyl-CoA desaturase and intracellular lipid signaling as novel players in regulation of thyroid hormone action in the heart

2014/13/B/NZ4/00199

Keywords:

stearoyl-CoA desaturase lipids heart triiodothyronine thyroxine thyroid receptor autophagy

Descriptors:

  • NZ4_2: Physiology
  • NZ4_6: Endocrinology
  • NZ4_11: Metabolism

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Paweł Dobrzyń 

Number of co-investigators in the project: 5

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 949 000 PLN

Project start date (Y-m-d): 2015-03-13

Project end date (Y-m-d): 2019-03-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (11)
  1. Białkowe czynniki lipogenne - rola w regulacji metabolizmu i funkcji mięśnia sercowego
    Authors:
    T. Bednarski, A. Pyrkowska, A. Opasinska, P. Dobrzyn
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (rok: 2016, tom: 70, strony: 644-653), Wydawca: Instytut Immunologii i Terapii Doświadczalnej PAN
    Status:
    Published
    DOI:
    10.5604/17322693.1206541 - link to the publication
  2. Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic beta-cells
    Authors:
    J. Janikiewicz, K. Hanzelka, A. Dziewulska, K. Kozinski, P. Dobrzyn, T. Bernas, A. Dobrzyn
    Academic press:
    Journal of Lipid Research (rok: 2015, tom: 56, strony: 1901-1911), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1194/jlr.M059980 - link to the publication
  3. SCD1 regulates the AMPK/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle
    Authors:
    A. Dziewulska A, A.M. Dobosz, A. Dobrzyn, A. Smolinska, K. Kolczynska, J.M. Ntambi, P. Dobrzyn
    Academic press:
    Journal of Cellular Physiology (rok: 2020, tom: 1865, strony: 1129-1140), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.29026 - link to the publication
  4. Stearoyl-CoA desaturase 1 deficiency reduces lipid accumulation in the heart by activating lipolysis independently of peroxisome proliferator-activated receptor alpha
    Authors:
    T. Bednarski, A. Olichwier, A. Opasinska, A. Pyrkowska, A.M. Gan, J.M. Ntambi, P. Dobrzyn
    Academic press:
    Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids (rok: 2016, tom: 1861, strony: 2029-2037), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.005 - link to the publication
  5. The role of stearoyl-CoA desaturase in the regulation of cardiac metabolism
    Authors:
    S. Tabaczar, M. Wołosiewicz, A. Filip, A. Olichwier, P. Dobrzyn
    Academic press:
    Postępy Biochemii (rok: 2018, tom: 64, strony: 183-189), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_130 - link to the publication
  6. Cardiospecific deletion of αE-catenin leads to heart failure and lethality in mice
    Authors:
    V.V. Balatskyi, L.L. Macewicz, A.M. Gan, S.V. Goncharov, P. Pawelec, G.V. Portnichenko, T.Y. Lapikova-Bryginska, V.O. Navrulin, V.E. Dosenko, A. Olichwier, P. Dobrzyn, O.O. Piven
    Academic press:
    Pflügers Archiv - European Journal of Physiology (rok: 2018, tom: 470, strony: 1485-1499), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00424-018-2168-2 - link to the publication
  7. Interplay between thyroid hormones and stearoyl-CoA desaturase 1 in the regulation of lipid metabolism in the heart
    Authors:
    A. Olichwier, V.V. Balatskyi, M. Wolosiewicz, J.M. Ntambi, P. Dobrzyn
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 109), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22010109 - link to the publication
  8. Mitochondria and reactive oxygen species in aging and age-related diseases
    Authors:
    C. Giorgi, S. Marchi, I.C.M. Simoes, Z. Ren, G. Morciano, M. Perrone, P. Patalas-Krawczyk, S. Borchard, P. Jędrak, K. Pierzynowska, J. Szymański, D.Q. Wang, P. Portincasa, G. Węgrzyn, H. Zischka, P. Dobrzyn, M. Bonora, J. Duszynski, A. Rimessi, A. Karkucinska-Wieckowska, A. Dobrzyn, G. Szabadkai, B. Zavan, P.J. Oliveira, V.A. Sardao, P. Pinton, M.R. Wieckowski
    Academic press:
    International Review of Cell and Molecular Biology (rok: 2018, tom: 340, strony: 209-344), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/bs.ircmb.2018.05.006 - link to the publication
  9. Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and β-catenin binding in pancreatic β-cells
    Authors:
    M. Jazurek-Ciesiolka, J. Janikiewicz, P. Dobrzyn, A. Dziewulska, K. Kozinski, A. Dobrzyn
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (rok: 2019, tom: 1865, strony: 2753-2764), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2019.06.018 - link to the publication
  10. Stearoyl-CoA desaturase 1 as a therapeutic target for the treatment of cancer
    Authors:
    Z. Tracz-Gaszewska, P. Dobrzyn
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 948), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11070948 - link to the publication
  11. Adipose- and muscle-derived Wnts trigger pancreatic beta-cell adaptation to systemic insulin resistance
    Authors:
    K. Kozinski, M. Jazurek, P. Dobrzyn, J. Janikiewicz, K. Kolczynska, A. Gajda, A. Dobrzyn
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: 31553), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/spep31553 - link to the publication
  1. Development of hypertension-induced left ventricular hypertrophy is associated with impairment of lipolysis in cardiomyocytes
    Authors:
    T. Bednarski, M. Duda, P. Dobrzyn
    Conference:
    44th European Muscle Conference, Warszawa (rok: 2015, ), Wydawca: Springer
    Data:
    konferencja 21-25 wrzesień
    Status:
    Published
  2. Lipid metabolism in hyperthyroid heart - the role of stearoyl-CoA desaturase 1
    Authors:
    A. Olichwier, P. Dobrzyn
    Conference:
    The 2016 Obesity Summit (rok: 2016, ), Wydawca: EuroSciCon
    Data:
    konferencja 12-14 kwiecień
    Status:
    Published
  3. Role of stearoyl-CoA desaturase 1 and thyroid hormones in epigenetic regulation in the heart
    Authors:
    A. Olichwier, A.M. Dobosz, M. Ghanim, P. Dobrzyn
    Conference:
    FEBS Workshop on Chromatin Proteomics (rok: 2016, ), Wydawca: FEBS
    Data:
    konferencja 3-8 październik
    Status:
    Published
  4. Functional impact of stearoyl-CoA desaturase 1 deficiency on thyroid hormone signaling
    Authors:
    A. Olichwier, A. Pyrkowska, P. Dobrzyn
    Conference:
    44th European Muscle Conference, Warszawa (rok: 2015, ), Wydawca: Springer
    Data:
    konferencja 21-25 wrzesień
    Status:
    Published
  5. The role of SCD1 in thyroid hormone dependent control of epigenetic modification in cardiomyocytes
    Authors:
    A. Olichwier, A. Filip, M. Wolosiewicz, P. Dobrzyn
    Conference:
    43rd The Federation of European Biochemical Societies Congress (rok: 2018, ), Wydawca: Wiley
    Data:
    konferencja 7-12 lipiec
    Status:
    Published
  6. Activity of Akt/mTOR pathway depends on type and time of hypertensive stimuli in the heart
    Authors:
    T. Bednarski, M. Duda, P. Dobrzyn
    Conference:
    40th The Federation of European Biochemical Societies Congress, Berlin, Niemcy (rok: 2015, ), Wydawca: The Federation of European Biochemical Societies
    Data:
    konferencja 4-9 lipiec
    Status:
    Published
  7. Role of stearoyl-CoA desaturase 1 (SCD1) in the regulation of Akt and ERK1/2 signaling pathways in hyperthyroidic heart
    Authors:
    A. Olichwier, A. Filip, V. Navrulin, P. Dobrzyn
    Conference:
    27th Congress of the Polish Physiological Society (rok: 2017, ), Wydawca: Polish Physiological Society
    Data:
    konferencja 21-22 wrzesień
    Status:
    Published
  8. Role of stearoyl-CoA desaturase 1 in regulation of epigenetic modifications via genomic and nongenomic thyroid hormone action in the heart
    Authors:
    A. Olichwier, P. Dobrzyn
    Conference:
    FEBS Advanced Lecture Course on Nuclear Receptors and Epigenomic Mechanisms in Human Disease and Aging (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja 27 sierpień - 1 wrzesień
    Status:
    Published
  9. Loss of stearoyl-CoA desaturase 1 affects thyroid hormnone action and induces epigenetic modofications in cardiomyocytes
    Authors:
    A. Olichwier, P. Dobrzyn
    Conference:
    42nd Annual Meeting of the European Thyroid Association (rok: 2019, ), Wydawca: Karger
    Data:
    konferencja 7-10 wrzesień
    Status:
    Published
  10. Regulation of cardiac lipid metabolism by stearoyl-CoA desaturase 4 in hyperthyroidism
    Authors:
    M. Ghanim, A. Olichwier, P. Dobrzyn
    Conference:
    FEBS Advanced Lecture Course on "Redox Regulation of Metabolic Processes" (rok: 2016, ), Wydawca: FEBS
    Data:
    konferencja 19-25 wrzesień
    Status:
    Published
  11. Role of stearoyl-CoA desaturase 1 (SCD1) in thyroid hormone mediated regulation of lipid metabolism in the heart
    Authors:
    A. Olichwier, P. Pawelec, P. Dobrzyn
    Conference:
    International Conference on the Bioscenece of Lipids (rok: 2017, ), Wydawca: ICBL
    Data:
    konferencja 10-14 wrzesień
    Status:
    Published

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