Understanding the interactions of zinc with zincophores and zinc transporters in fungal pathogens

2014/13/D/ST5/02868

Keywords

Descriptors

  • ST5_14: Chemia koordynacyjna
  • ST5_16: Chemia biologiczna
  • ST5_24: Chemia nieorganiczna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet Wrocławski, Wydział Chemii

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Magdalena Rowińska-Żyrek

Number of co-investigators in the project: 2

Call

SONATA 7 – announced on 2014-03-17

Amount awarded
448 620 PLN
Project start date
2015-02-12
Project end date
2018-09-11
Project duration
43 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. potencjometr. Cost: 140 000 PLN
  2. spektrofotometr UV-Vis.

Information in the final report

Publication in academic press/journals (14)

  1. Zinc homeostasis at the bacteria/host interface—from coordination chemistry to nutritional immunity.

    Authors:
    Wątły J., Potocki S., Rowińska-Żyrek M.
    Academic press:
    Chemistry-A European Journal (year: 2016, volume: 22, pages: 15992-16010), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/chem.201602376 – link to the publication
  2. 'Coordination of Zn2+ and Cu2+ to the membrane disrupting fragment of amylin

    Authors:
    Rowińska-Żyrek M.
    Academic press:
    Dalton Transactions (year: 2016, volume: 45, pages: 8099-8106), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6dt00628k – link to the publication
  3. Fungal zinc homeostasis - a tug of war between the pathogen and host

    Authors:
    Walencik Paulina K., Wątły Joanna, Rowińska-Żyrek Magdalena
    Academic press:
    Current Medicinal Chemistry (year: 2016, volume: 23, pages: 3717-3729), Publisher: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/0929867323666160817163834 – link to the publication
  4. Zn(II) - pramlintide : stability, binding sites and unexpected aggregation

    Authors:
    Łoboda D., Rowińska-Żyrek M.
    Academic press:
    Journal of Inorganic Biochemistry (year: 2017, volume: 174, pages: 150-155), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2017.06.008 – link to the publication
  5. Zinc binding site in Pra1, a zincophore from Candida albicans

    Authors:
    Łoboda D., Rowińska-Żyrek M.
    Academic press:
    Dalton Transactions (year: 2017, volume: 46, pages: 13695-13703), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7dt01675a – link to the publication
  6. Impact of histidine spacing on modified polyhistidine tag : metal ion interactions

    Authors:
    Wątły J., Hecel A., Rowińska-Żyrek M., Kozłowski H.
    Academic press:
    Inorganica Chimica Acta (year: 2018, volume: 472, pages: 119-126), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ica.2017.06.053 – link to the publication
  7. Ag + complexes as potential therapeutic agents in medicine and pharmacy

    Authors:
    Hecel A., Kolkowska P., Krzywoszynska K., Szebesczyk A., Rowinska-Zyrek M., Kozlowski H.
    Academic press:
    Current Medicinal Chemistry (year: 2019, volume: 26(4), pages: 624-647), Publisher: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/0929867324666170920125943 – link to the publication
  8. Poly-Xaa Sequences in Proteins – Biological Role and Interactions with Metal Ions. Chemical and Medical Aspects

    Authors:
    Wątły J., Hecel A., Kołkowska P., Kozłowski H., Rowińska-Żyrek M.
    Academic press:
    Current Medicinal Chemistry (year: 2018, volume: 25, pages: 22-48), Publisher: Bentham Science Publishers
    Status:
    Published
  9. Investigation on the metal binding sites of a putative Zn(II) transporter in opportunistic yeast species Candida albicans

    Authors:
    Belotti D., Łoboda D., Rowińska-Żyrek M., Remelli M.
    Academic press:
    New Journal of Chemistry (year: 2018, volume: 42, pages: 8123-8130), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8NJ00533H – link to the publication
  10. Histidine tracts in human transcription factors: insight into metal ion coordination ability

    Authors:
    Hecel A., Wątły J., Rowińska-Żyrek M., Świątek-Kozłowska J., Kozłowski H.
    Academic press:
    Journal of Biological Inorganic Chemistry (year: 2018, volume: 23, pages: 81-90), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1007/s00775-017-1512-x – link to the publication
  11. Periplasmic HupE region-Ni2+ interactions: Thermodynamics, binding mode and competition with Cu2+ and Zn2+

    Authors:
    Rowińska-Żyrek, M.
    Academic press:
    Inorganica Chimica Acta (year: 2017, volume: 460, pages: 141-147), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ica.2016.08.007 – link to the publication
  12. Candida albicans zincophore and zinc transporter interactions with Zn(II) and Ni(II)

    Authors:
    Łoboda D., Rowińska-Żyrek M.
    Academic press:
    Dalton Transactions (year: 2018, volume: 47, pages: 2646-2654), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7dt04403h – link to the publication
  13. HENRYK — An endless source of metal coordination surprises

    Authors:
    Kołkowska P., Hecel A., Kędzierska D., Ostrowska M., Walencik P., Wątły J., Zdyb K., Spodzieja M., Rodziewicz-Motowidło S., Potocki S., Łuczkowski M., Gumienna-Kontecka E., Rowińska-Żyrek M.
    Academic press:
    Journal of Inorganic Biochemistry (year: 2016, volume: 163, pages: 258-265), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2016.02.030 – link to the publication
  14. Metal interactions with the transmembrane region of HupE Ni2+ transporter explain its efficiency

    Authors:
    Rowińska-Żyrek M.
    Academic press:
    Journal of Inorganic Biochemistry (year: 2018, volume: 180, pages: 33-38), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2017.11.026 – link to the publication

Book publications / chapters in book publications (2)

  1. Nickel Binding Sites – Coordination Modes and Thermodynamics

    Authors:
    Rowińska-Żyrek M., Kozłowski H.
    Book:
    The biological inorganic chemistry of nickel (year: 2017, volume: 1, pages: 43-59), Publisher: Royal Society of Chemistry
    Status:
    Published
  2. The role of trace elements in living organisms

    Authors:
    Gumienna-Kontecka E., Rowińska-Żyrek M., Łuczkowski M.
    Book:
    Recent advances in trace elements (year: 2018, volume: 1, pages: 177-206), Publisher: Wiley
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski