Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Antigens of human blood group systems P1PK and GLOB as receptors for Shiga toxins

2014/13/B/NZ6/00227

Keywords:

Shiga toxin receptor glycosphingolipid blood group system P1PK and GLOB

Descriptors:

  • NZ6_8: Other related subjects
  • NZ6_4: Bacteriology
  • NZ6_2: Clinical immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Czerwiński 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 590 000 PLN

Project start date (Y-m-d): 2015-03-02

Project end date (Y-m-d): 2020-03-01

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Blok termiczny z zagęszczaniem próbek (7 500 PLN)
  2. Piec wysokotemperaturowy (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase
    Authors:
    Kaczmarek R., Mikołajewicz K., Szymczak K., Duk M., Majorczyk E., Krop-Watorek A., Buczkowska A.,Czerwinski M.
    Academic press:
    Glycoconjugate Journal (rok: 2016, tom: 33, strony: 963-973), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10719-016-9716-9 - link to the publication
  2. Mikołajczyk K., Kaczmarek R., Czerwiński M.: Czy mutacje w genie kodującym czynnik transkrypcyjny EKLF (Erythroid Krüppel-Like Factor) mogą chronić nas przed chorobami zakaźnymi i pasożytniczymi?
    Authors:
    Mikołajczyk K., Kaczmarek R., Czerwiński M.
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (rok: 2016, tom: 70, strony: 1068-1086), Wydawca: Index Copernicus
    Status:
    Published
    DOI:
    10.5604/17322693.1221384 - link to the publication
  3. D1: a singed cat of the three antigen presentation systems
    Authors:
    Kaczmarek R., Pasciak M., Szymczak-Kulus K., Czerwinski M.
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2017, tom: 65, strony: 201-214), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00005-017-0461-y - link to the publication
  4. Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry
    Authors:
    Szymczak-Kulus K, Weidler S, Bereznicka A, Mikolajczyk K, Kaczmarek R, Bednarz B, Zhang T, Urbaniak A, Olczak M, Park EY, Majorczyk E, Kapczynska K, Lukasiewicz J, Wuhrer M, Unverzagt C, Czerwinski M.
    Academic press:
    Journal of Biological Chemistry (rok: 2021, tom: 296, strony: 100299 1-17), Wydawca: American Society of Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1016/j.jbc.2021.100299 - link to the publication
  5. Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group syste
    Authors:
    Kaczmarek R., Szymczak-Kulus K., Bereźnicka A., Mikołajczyk K., Duk M., Majorczyk E., Krop-Watorek A., Klausa E., Skowrońska J., Michalewska B., Brojer E., Czerwinski M
    Academic press:
    PLoS One (rok: 2018, tom: 13, strony: e0196627), Wydawca: PLoS Journals
    Status:
    Published
    DOI:
    10.1371/journal.pone.0196627 - link to the publication