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Antigens of human blood group systems P1PK and GLOB as receptors for Shiga toxins

2014/13/B/NZ6/00227

Keywords

Descriptors

  • NZ6_8: Inne zagadnienia pokrewne
  • NZ6_4: Bakteriologia
  • NZ6_2: Immunologia kliniczna

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Marcin Czerwiński

Number of co-investigators in the project: 7

Call

OPUS 7 – announced on 2014-03-17

Amount awarded
590 000 PLN
Project start date
2015-03-02
Project end date
2020-03-01
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Blok termiczny z zagęszczaniem próbek. Cost: 7 500 PLN
  2. Piec wysokotemperaturowy. Cost: 4 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. D1: a singed cat of the three antigen presentation systems

    Authors:
    Kaczmarek R., Pasciak M., Szymczak-Kulus K., Czerwinski M.
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (year: 2017, volume: 65, pages: 201-214), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00005-017-0461-y – link to the publication

  2. Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase

    Authors:
    Kaczmarek R., Mikołajewicz K., Szymczak K., Duk M., Majorczyk E., Krop-Watorek A., Buczkowska A.,Czerwinski M.
    Academic press:
    Glycoconjugate Journal (year: 2016, volume: 33, pages: 963-973), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s10719-016-9716-9 – link to the publication

  3. Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group syste

    Authors:
    Kaczmarek R., Szymczak-Kulus K., Bereźnicka A., Mikołajczyk K., Duk M., Majorczyk E., Krop-Watorek A., Klausa E., Skowrońska J., Michalewska B., Brojer E., Czerwinski M
    Academic press:
    PLoS One (year: 2018, volume: 13, pages: e0196627), Publisher: PLoS Journals
    Status:
    Published
    DOI:
    10.1371/journal.pone.0196627 – link to the publication

  4. Mikołajczyk K., Kaczmarek R., Czerwiński M.: Czy mutacje w genie kodującym czynnik transkrypcyjny EKLF (Erythroid Krüppel-Like Factor) mogą chronić nas przed chorobami zakaźnymi i pasożytniczymi?

    Authors:
    Mikołajczyk K., Kaczmarek R., Czerwiński M.
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (year: 2016, volume: 70, pages: 1068-1086), Publisher: Index Copernicus
    Status:
    Published
    DOI:
    10.5604/17322693.1221384 – link to the publication

  5. Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry

    Authors:
    Szymczak-Kulus K, Weidler S, Bereznicka A, Mikolajczyk K, Kaczmarek R, Bednarz B, Zhang T, Urbaniak A, Olczak M, Park EY, Majorczyk E, Kapczynska K, Lukasiewicz J, Wuhrer M, Unverzagt C, Czerwinski M.
    Academic press:
    Journal of Biological Chemistry (year: 2021, volume: 296, pages: 100299 1-17), Publisher: American Society of Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1016/j.jbc.2021.100299 – link to the publication

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Graphic design and implementation: Jakub Piotrowski