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Influence of the chemical structure of coumarins derivatives on their central effects evaluated in behavioral and bichemical studies

2014/13/B/NZ4/01249

Keywords

Descriptors

  • NZ4_12: Inne zagadnienia pokrewne
  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Voivodeship: lubelskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Barbara Budzyńska

Number of co-investigators in the project: 5

Call

OPUS 7 – announced on 2014-03-17

Amount awarded
753 760 PLN
Project start date
2015-01-23
Project end date
2018-07-22
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. komputer przenośny Netebook Lenovo IP B51-80 z wyposażeniem.
  2. Aktymetry - aparatura od pomiaru aktywmości lokomotorycznej myszy. Cost: 90 000 PLN
  3. Cyfrowy skaner chemiluminescencji do wizualizacji membran (Western Blot). Cost: 35 000 PLN
  4. Generator azotu 4l/min, czystość 97,5%. Cost: 35 000 PLN
  5. Gilotyna dla średnich zwierząt 2 szt po 3.382,50 zł.
  6. Homogenizator ultradźwiękowy UP 100h, Sonotrada MS 1, Statyw ST 116.
  7. Pompa do chromatografu cieczowego.
  8. Uniwersalna stołowa wirówka laboratoryjna z chłodzeniem, zakres obrotów 100 - 18.000 obr/min, zakres regulacji temperatury -20 do +40. Cost: 20 000 PLN
  9. zamrażarka -80 st.C. Cost: 60 000 PLN

Information in the final report

Publication in academic press/journals (2)

  1. In vivo modulation of the behavioral effects of nicotine b y the coumarins xanthotoxin, bergapten, and umbelliferone

    Authors:
    Barbara Budzynska, Krystyna Skalicka-Wozniak, Marta Kruk-Slomka, Malgorzata Wydrzynska-Kuzma, Grazyna Biala
    Academic press:
    Psychopharmacology (year: 2016, volume: -, pages: 2289-2300), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-016-4279-9 – link to the publication

  2. Scopolamine-Induced Memory Impairment Is Alleviated by Xanthotoxin: Role of Acetylcholinesterase and Oxidative Stress Processes.

    Authors:
    Skalicka-Wozniak K, Budzynska B, Biala G, Boguszewska-Czubara A.
    Academic press:
    ACS Chem Neurosci. (year: 2018, volume: -, pages: -), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acschemneuro.8b00011 – link to the publication

Articles in post-conference publications (15)

  1. Umbelliferone prolonged the behavioral effects of nicotine in animal models

    Authors:
    Barbara Budzyńska, Ewelina Kozioł, Małgorzata Wydrzyńska-Kuźma, Marta Kruk-Słomka, Grażyna Biała, Krystyna Skalicka-Woźniak.
    Conference:
    10th International Symposium on Chromatography of Natural Products : The application of analytical methods for the development of natural products (year: 2016, pages: 168), Publisher: -
    Date:
    conference 6-9 czerwiec
    Status:
    Published

  2. Effects of xanthotoxin on memory processes induces by nicotine in mice

    Authors:
    BARBARA BUDZYŃSKA, KRYSTYNA SKALICKA-WOŹNIAK, MARTA KRUK-SŁOMKA, MAŁGORZATA WYDRZYŃSKA - KUŹMA, GRAŻYNA BIAŁA
    Conference:
    4th International Conference and Workshop : Plant - the source of research material. Lublin, (year: 2015, pages: 80), Publisher: -
    Date:
    conference 20-23.09
    Status:
    Published

  3. Wpływ ksantotoksyny na behawioralne efekty nikotyny oceniane w zwierzęcych modelach doświadczalnych

    Authors:
    Ewelina Kozioł, Barbara Budzyńska, Małgorzata Wydrzyńska - Kuźma, Krystyna Skalicka-Woźniak, Grażyna Biała.
    Conference:
    VII Lubelskie Sympozjum Doktorantów Nauk Farmaceutycznych wraz z Otwartym Seminarium Nauk o Życiu (year: 2016, pages: -), Publisher: -
    Date:
    conference 19,04
    Status:
    Published
    DOI:
    link to the publication

  4. Mechanisms of acute and chronic administration of bergapten induced improvement in memory and learning processes in passive avoidance test in mice

    Authors:
    Anna Boguszewska-Czubara, Krystyna Skalicka-Woźniak, Marta Kruk-Słomka, Grażyna Biała, Barbara Budzyńska.
    Conference:
    2nd Congress BIO 2016 Expanding beyond the limits. 50th Meeting of the Polish Biochemical Society. 13th Conference of the Polish Society for Cell Biology. Wrocław, (year: 2016, pages: 148), Publisher: Polish Biochemical Society, Polish Society for Cell Biology
    Date:
    conference 13-16.09
    Status:
    Published
    DOI:
    link to the publication

  5. Effects of xanthotoxin on memory precesses and oxydative stress.

    Authors:
    BARBARA BUDZYŃSKA, ANNA BOGUSZEWSKA-CZUBARA, MARTA KRUK-SŁOMKA, KRYSTYNA SKALICKA-WOŹNIAK, MAŁGORZATA WYDRZYŃSKA-KUŹMA, GRAŻYNA BIAŁA.
    Conference:
    European Brain Behaviour Society & European Behavioural Pharmacology Society Joint Meeting (year: 2015, pages: 53), Publisher: -
    Date:
    conference 12-15.09
    Status:
    Published
    DOI:
    link to the publication

  6. Effects of bergapten on memory processes and oxidative stress.

    Authors:
    ANNA BOGUSZEWSKA-CZUBARA, BARBARA BUDZYŃSKA, MARTA KRUK-SŁOMKA, KRYSTYNA SKALICKA-WOŹNIAK, MAŁGORZATA WYDRZYŃSKA - KUŹMA, GRAŻYNA BIAŁA.
    Conference:
    VII Konwersatorium Chemii Medycznej & VIII Sympozjum PTBI. Lublin, (year: 2015, pages: -), Publisher: -
    Date:
    conference 17-19.09
    Status:
    Published

  7. Coumarins - from counter-current chromatography isolation to central nervous system activity.

    Authors:
    KRYSTYNA SKALICKA-WOŹNIAK, BARBARA BUDZYŃSKA.
    Conference:
    2nd International Conference on Natural Products Utilization: From Plants to Pharmacy Shelf. Plovdiv (year: 2015, pages: 31), Publisher: -
    Date:
    conference 14-17.10
    Status:
    Published

  8. Wpływ umbeliferonu na procesy pamięciowe indukowane nikotyną u myszy

    Authors:
    OLGA WRONIKOWSKA, KRYSTYNA SKALICKA-WOŹNIAK, BARBARA BUDZYŃSKA
    Conference:
    X Interdyscyplinarna Konferencja Naukowa TYGIEL 2018 : Interdyscyplinarność kluczem do rozwoju (year: 2018, pages: 316), Publisher: Wydawnictwo Tygiel
    Date:
    conference 17-18 marca
    Status:
    Published
    DOI:
    link to the publication

  9. Xanthotoxin administration affects on nicotine - induced memory processes in passive aviodance test in mice.

    Authors:
    Barbara Budzyńska, Anna Boguszewska-Czubara, Grażyna Biała, Marta Kruk-Słomka, Małgorzata Wydrzyńska-Kuźma, Krystyna Skalicka-Woźniak.
    Conference:
    EBPS Biennial Meeting 2017. Heraklion (year: 2017, pages: B01), Publisher: nie dotyczy
    Date:
    conference 311.08-03.09.
    Status:
    Published

  10. Wpływ umbeliferonu na zachowania lękowe u myszy oceniane w teście podniesionego labiryntu krzyżowego.

    Authors:
    JOANNA KOWALCZYK, EWA POLESZAK, KRYSTYNA SKALICKA-WOŹNIAK.
    Conference:
    X Interdyscyplinarna Konferencja Naukowa TYGIEL 2018 : Interdyscyplinarność kluczem do rozwoju. (year: 2018, pages: 104-105), Publisher: Tygiel
    Date:
    conference 17-18 marca 2018
    Status:
    Published

  11. Effect of umbelliferone on scopolamine-induced cognitive impairment in passive avoidance test in mice.

    Authors:
    JOANNA KOWALCZYK, KRYSTYNA WOŹNIAK, KATARZYNA KASZUBSKA, GRAŻYNA BIAŁA, EWA POLESZAK, MAŁGORZATA WYDRZYŃSKA-KUŹMA, BARBARA BUDZYŃSKA
    Conference:
    11th FENS Forum of Neuroscience. (year: 2018, pages: -), Publisher: FENS
    Date:
    conference 7-11 July
    Status:
    Published

  12. Xanthotoxin improves scopolamine induced memory impairment in passive avoidance test in mice – role of acetylcholinesterase.

    Authors:
    K[ystyna Skalicka-Woźniak, Anna Boguszewska-Czubara, Grażyna Biała, Serena. Silvestro, Caterina Faggio, Barbara Budzyńska.
    Conference:
    90° Conv. Società Italiana di Biologia Sperimentale, Trapani (Italy) (year: 2017, pages: 13-14), Publisher: Journal of Biological Research (Italy)
    Date:
    conference 27-28.10
    Status:
    Published
    DOI:
    link to the publication

  13. Preparative separation of bergapten as a novel compound for the treatment of nicotinism

    Authors:
    Krystyna Skalicka-Woźniak, Barbara Budzyńska, Małgorzata Wydrzyńska - Kuźma, Ewelina Kozioł, Grażyna Biała
    Conference:
    Countercurrent Chromathography Conference CCC 2016. Chicago (year: 2016, pages: 2), Publisher: -
    Date:
    conference 1-3.08
    Status:
    Published

  14. Counter-current chromatography with HPLC/DAD/ESI-TOF or GC/MS - an efficient platform for separation of natural compounds

    Authors:
    KRYSTYNA SKALICKA-WOŹNIAK
    Conference:
    International Symposium on Advances in Extraction Technologies and 22nd International Symposium on Separation Sciences (year: 2016, pages: 69), Publisher: -
    Date:
    conference 3-6 CZERWIEC
    Status:
    Published

  15. Hyphenated HPCCC and HPLC/DAD/ESI-TOF as a platform for searching of biologically active coumarins from apiaceae plants

    Authors:
    KRYSTYNA SKALICKA-WOŹNIAK
    Conference:
    Countercurrent Chromathography Conference CCC 2016 (year: 2016, pages: 64), Publisher: -
    Date:
    conference 1-3 SIERPIEŃ
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski