Nowe syntetyczne analogi kapu mRNA i ich zastosowania w badaniach biochemicznych i strukturalnych nad enzymatycznym kompleksem degradującym kap Dcp2/Dcp1 i innymi białkami oddziałującymi z kapem
2014/12/T/NZ1/00528
Descriptors
- NZ1_2: Biochemia
- NZ1_4: Biologia strukturalna
- ST5_16: Chemia biologiczna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Warszawski, Wydział Fizyki
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
ETIUDA 2 – announced on 2013-12-16
- Amount awarded
- 98 540 PLN
- Project start date
- 2014-10-01
- Project end date
- 2015-09-30
- Project duration
- 12 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (3)
-
Structural basis of mRNA-cap recognition by Dcp1-Dcp2.
- Authors:
- J. S. Mudridge, M. Ziemniak, J. Jemielity, J. D. Gross.
- Academic press:
- Nature Structural & Molecular Biology (year: 2016, volume: ahead of print, pages: ahead of print), Publisher: Nature Publishing Group
- Status:
- Published
- DOI:
- 10.1038/nsmb.3301 – link to the publication
-
Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.
- Authors:
- Ziemniak, M., J. S. Mudridge, J. Kowalska, R. E. Rhoads, J. D. Gross, J. Jemielity
- Academic press:
- RNA (year: 2016, volume: 22, pages: 518-529), Publisher: Cold Spring Harbor Laboratory Press for the RNA Society
- Status:
- Published
- DOI:
- 10.1261/rna.055152.115 – link to the publication
-
Phosphate-modified analogues of m7GTP and m7Gppppm7G - Synthesis and biochemical properties.
- Authors:
- Ziemniak, M., J. Kowalska, M. Lukaszewicz, J. Zuberek, K. Wnek, E. Darzynkiewicz, J. Jemielity
- Status:
- Accepted for publication