Projects funded by the NCN
Nowe syntetyczne analogi kapu mRNA i ich zastosowania w badaniach biochemicznych i strukturalnych nad enzymatycznym kompleksem degradującym kap Dcp2/Dcp1 i innymi białkami oddziałującymi z kapem
2014/12/T/NZ1/00528
Keywords:
Descriptors:
- NZ1_2: Biochemistry
- NZ1_4: Structural biology
- ST5_16:
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Uniwersytet Warszawski, Wydział Fizyki
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: ETIUDA 2 - announced on 2013-12-16
Amount awarded: 98 540 PLN
Project start date (Y-m-d): 2014-10-01
Project end date (Y-m-d): 2015-09-30
Project duration:: 12 months (the same as in the proposal)
Project status: Project settled
Information in the final report
- Publication in academic press/journals (3)
- Phosphate-modified analogues of m7GTP and m7Gppppm7G - Synthesis and biochemical properties.Authors:Ziemniak, M., J. Kowalska, M. Lukaszewicz, J. Zuberek, K. Wnek, E. Darzynkiewicz, J. JemielityAcademic press:Bioorganic & Medicinal Chemistry (rok: 2015, tom: 23, strony: 5369-5381), Wydawca: ElsevierStatus:Accepted for publicationDOI:10.1016/j.bmc.2015.07.052 - link to the publication
- Structural basis of mRNA-cap recognition by Dcp1-Dcp2.Authors:J. S. Mudridge, M. Ziemniak, J. Jemielity, J. D. Gross.Academic press:Nature Structural & Molecular Biology (rok: 2016, tom: ahead of print, strony: ahead of print), Wydawca: Nature Publishing GroupStatus:PublishedDOI:10.1038/nsmb.3301 - link to the publication
- Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.Authors:Ziemniak, M., J. S. Mudridge, J. Kowalska, R. E. Rhoads, J. D. Gross, J. JemielityAcademic press:RNA (rok: 2016, tom: 22, strony: 518-529), Wydawca: Cold Spring Harbor Laboratory Press for the RNA SocietyStatus:PublishedDOI:10.1261/rna.055152.115 - link to the publication