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Mitochondrial RNA decay and surveillance - comprehensive interdisciplinary studies.

2014/12/W/NZ1/00463

Keywords

Descriptors

  • ST5_16: Chemia biologiczna
  • NZ2_1: Genetyka molekularna
  • NZ1_3: Biofizyka

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Marcin Piotr Nowotny

Number of co-investigators in the project: 16

Call

SYMFONIA 2 – announced on 2013-12-16

Amount awarded
6 879 968 PLN
Project start date
2014-12-09
Project end date
2020-12-08
Project duration
72 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Cytometr przepływowy.
  2. Serwer plików i aplikacji. Cost: 100 000 PLN
  3. Ultrawirówka. Cost: 190 000 PLN

Information in the final report

Publication in academic press/journals (9)

  1. The Pet127 protein is a mitochondrial 5'-to-3' exoribonuclease from the PD-(D/E)XK superfamily involved in RNA maturation and intron degradation in yeasts

    Authors:
    Łabędzka-Dmoch K, Rażew M, Gapińska M, Piątkowski J, Kolondra A, Salmonowicz H, Wenda JM, Nowotny M, Golik P
    Academic press:
    RNA (year: 2022, volume: 28, pages: 711-728), Publisher: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna – link to the publication

  2. Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components

    Authors:
    Razew M, Warkocki Z, Taube M, Kolondra A, Czarnocki-Cieciura M, Nowak E, Labedzka-Dmoch K, Kawinska A, Piatkowski J, Golik P, Kozak M, Dziembowski A, Nowotny M
    Academic press:
    Nature Communications (year: 2018, volume: 9(1), pages: 97), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41467-017-02570-5 – link to the publication

  3. Yeast pentatricopeptide protein Dmr1 (Ccm1) binds a repetitive AU-rich motif in the small subunit mitochondrial ribosomal RNA

    Authors:
    J. Piątkowski, P. Golik
    Academic press:
    RNA (year: 2020, volume: 26, pages: 1268-1282), Publisher: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.074880.120 – link to the publication

  4. Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria

    Authors:
    Anna V. Kotrys, Dominik Cysewski, Sylwia D. Czarnomska, Zbigniew Pietras, Lukasz S. Borowski, Andrzej Dziembowski, Roman J. Szczesny
    Academic press:
    Nucleic Acids Research (year: 2019, volume: 47, pages: 7502-7517), Publisher: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkz542 – link to the publication

  5. Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria

    Authors:
    Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski & Roman J. Szczesny
    Academic press:
    Nature Communications (year: 2018, volume: 9, pages: -), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41467-018-05007-9 – link to the publication

  6. Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology

    Authors:
    Anna V. Kotrys, Roman J. Szczesny
    Academic press:
    Cells (year: 2019, volume: 9, pages: nie dotyczy), Publisher: MDPI (Multidisciplinary Digital Publishing Institute)
    Status:
    Published
    DOI:
    10.3390/cells9010017 – link to the publication

  7. Pervasive transcription of the mitochondrial genome in Candida albicans is revealed in mutants lacking the mtEXO RNase complex

    Authors:
    Łabędzka-Dmoch K, Kolondra A, Karpińska MA, Dębek S, Grochowska J, Grochowski M, Piątkowski J, Hoang Diu Bui T, Golik P.
    Academic press:
    RNA Biology (year: 2021, volume: 18, pages: 303-317), Publisher: TAYLOR & FRANCIS INC
    Status:
    Published
    DOI:
    10.1080/15476286.2021.1943929 – link to the publication

  8. Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance

    Authors:
    Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski & Roman J. Szczesny
    Academic press:
    Molecular & Cellular Oncology (year: 2018, volume: 5, pages: -), Publisher: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.1080/23723556.2018.1516452 – link to the publication

  9. Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA

    Authors:
    Szewczyk M, Malik D, Borowski LS, Czarnomska SD, Kotrys AV, Klosowska-Kosicka K, Nowotny M, Szczesny RJ.
    Academic press:
    Nucleic Acids Research (year: 2020, volume: 48(10), pages: 5572-5590), Publisher: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkaa302 – link to the publication

Book publications / chapters in book publications (1)

  1. High-Throughput Measurement of Mitochondrial RNA Turnover in Human Cultured Cells

    Authors:
    Anna V. Kotrys, Łukasz Borowski, Roman J. Szczesny
    Book:
    Mitochondrial Gene Expression. (year: 2021, volume: n.d., pages: 133-146), Publisher: Springer Nature
    Status:
    Published

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