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Synteza, badania strukturalne i spektroskopowe oraz aktywność przeciwnowotworowa i przeciwdrobnoustrojowa nowych pochodnych salinomycyny

2014/12/T/ST5/00710

Descriptors

  • ST5_11: Synteza biomateriałów
  • ST5_16: Chemia biologiczna
  • ST5_23: Chemia organiczna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii UAM

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Michał Piotr Antoszczak

Number of co-investigators in the project: 2

Call

ETIUDA 2 – announced on 2013-12-16

Amount awarded
101 044 PLN
Project start date
2014-10-01
Project end date
2015-09-30
Project duration
12 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (8)

  1. Synthesis and biological activity of salinomycin conjugates with floxuridine

    Authors:
    Huczyński A., Antoszczak M., Kleczewska N., Baraniak D., Maj E., Stefańska J., Wietrzyk J., Janczak J., Celewicz L.
    Academic press:
    European Journal of Medicinal Chemistry (year: 2015, volume: 93, pages: 33-41), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2015.01.045 – link to the publication

  2. Anticancer activity of polyether ionophore – salinomycin

    Authors:
    Antoszczak M., Huczyński A.
    Academic press:
    Anti-Cancer Agents in Medicinal Chemistry (year: 2015, volume: 15, pages: 575-591), Publisher: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1871520615666150101130209 – link to the publication

  3. Synthesis, anticancer and antibacterial activity of salinomycin N-benzyl amides

    Authors:
    Antoszczak M., Maj E., Napiórkowska A., Stefańska J., Augustynowicz-Kopeć E., Wietrzyk J., Janczak J., Brzezinski B., Huczyński A.
    Academic press:
    Molecules (year: 2014, volume: 19, pages: 19435-19459), Publisher: MDPI AG
    Status:
    Published
    DOI:
    10.3390/molecules191219435 – link to the publication

  4. Antiproliferative activity of polyether antibiotc-Cinchona alkaloid conjugates obtained via click chemistry

    Authors:
    Skiera I., Antoszczak M., Trynda J., Wietrzyk J., Boratyński P., Kacprzak K., Huczyński A.
    Academic press:
    Chemical Biology & Drug Design (year: 2015, volume: 86, pages: 911-917), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.12523 – link to the publication

  5. Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters

    Authors:
    Antoszczak M., Sobusiak M., Maj E., Wietrzyk J., Huczyński A.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (year: 2015, volume: 25, pages: 3511-3514), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.06.086 – link to the publication

  6. Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis

    Authors:
    Stefańska J., Antoszczak M., Stępień K., Bartoszcze M., Mirski T., Huczyński A.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (year: 2015, volume: 25, pages: 2082-2088), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.03.085 – link to the publication

  7. Anti-proliferative activity of Monensin and its tertiary amide derivatives

    Authors:
    Huczyński A., Klejborowska G., Antoszczak M., Maj E., Wietrzyk J.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (year: 2015, volume: 25, pages: 4539-4543), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.08.067 – link to the publication

  8. Synthesis and antiproliferative activity of silybin conjugates with salinomycin and monensin

    Authors:
    Antoszczak M., Klejborowska G., Kruszyk M., Maj E., Wietrzyk J., Huczyński A.
    Academic press:
    Chemical Biology & Drug Design (year: 2015, volume: 86, pages: 1378-1386), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.12602 – link to the publication

Book publications / chapters in book publications (1)

  1. Structure and biological activity of polyether ionophores and their semi-synthetic derivatives

    Authors:
    Antoszczak M., Rutkowski J., Huczyński A.
    Book:
    Bioactive Natural Products. Chemistry and Biology (year: 2015, volume: 1st Edition, pages: 107-170), Publisher: Wiley-VCH Verlag GmbH
    Status:
    Published
    DOI:
    link to the publication

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