Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Synteza, badania strukturalne i spektroskopowe oraz aktywność przeciwnowotworowa i przeciwdrobnoustrojowa nowych pochodnych salinomycyny

2014/12/T/ST5/00710

Keywords:

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii UAM

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Michał Antoszczak 

Number of co-investigators in the project: 2

Call: ETIUDA 2 - announced on 2013-12-16

Amount awarded: 101 044 PLN

Project start date (Y-m-d): 2014-10-01

Project end date (Y-m-d): 2015-09-30

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (8)
  • Book publications / chapters in book publications (1)
  1. Synthesis and antiproliferative activity of silybin conjugates with salinomycin and monensin
    Authors:
    Antoszczak M., Klejborowska G., Kruszyk M., Maj E., Wietrzyk J., Huczyński A.
    Academic press:
    Chemical Biology & Drug Design (rok: 2015, tom: 86, strony: 1378-1386), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.12602 - link to the publication
  2. Synthesis, anticancer and antibacterial activity of salinomycin N-benzyl amides
    Authors:
    Antoszczak M., Maj E., Napiórkowska A., Stefańska J., Augustynowicz-Kopeć E., Wietrzyk J., Janczak J., Brzezinski B., Huczyński A.
    Academic press:
    Molecules (rok: 2014, tom: 19, strony: 19435-19459), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/molecules191219435 - link to the publication
  3. Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters
    Authors:
    Antoszczak M., Sobusiak M., Maj E., Wietrzyk J., Huczyński A.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2015, tom: 25, strony: 3511-3514), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.06.086 - link to the publication
  4. Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis
    Authors:
    Stefańska J., Antoszczak M., Stępień K., Bartoszcze M., Mirski T., Huczyński A.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2015, tom: 25, strony: 2082-2088), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.03.085 - link to the publication
  5. Synthesis and biological activity of salinomycin conjugates with floxuridine
    Authors:
    Huczyński A., Antoszczak M., Kleczewska N., Baraniak D., Maj E., Stefańska J., Wietrzyk J., Janczak J., Celewicz L.
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2015, tom: 93, strony: 33-41), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2015.01.045 - link to the publication
  6. Antiproliferative activity of polyether antibiotc-Cinchona alkaloid conjugates obtained via click chemistry
    Authors:
    Skiera I., Antoszczak M., Trynda J., Wietrzyk J., Boratyński P., Kacprzak K., Huczyński A.
    Academic press:
    Chemical Biology & Drug Design (rok: 2015, tom: 86, strony: 911-917), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.12523 - link to the publication
  7. Anti-proliferative activity of Monensin and its tertiary amide derivatives
    Authors:
    Huczyński A., Klejborowska G., Antoszczak M., Maj E., Wietrzyk J.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2015, tom: 25, strony: 4539-4543), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.08.067 - link to the publication
  8. Anticancer activity of polyether ionophore – salinomycin
    Authors:
    Antoszczak M., Huczyński A.
    Academic press:
    Anti-Cancer Agents in Medicinal Chemistry (rok: 2015, tom: 15, strony: 575-591), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1871520615666150101130209 - link to the publication
  1. Structure and biological activity of polyether ionophores and their semi-synthetic derivatives
    Authors:
    Antoszczak M., Rutkowski J., Huczyński A.
    Book:
    Bioactive Natural Products. Chemistry and Biology (rok: 2015, tom: 1st Edition, strony: 107-170), Wydawca: Wiley-VCH Verlag GmbH
    Status:
    Published
    DOI:
    link to the publication

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