Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Patient-specific iPS cells as a novel approach to study patophysiology of mTOR-related neurodevelopmental disorders

2013/11/D/NZ3/01079

Keywords:

induced pluripotent stem cells mTOR signaling patway tuberous sclerosis neurofibromatosis type 1

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_6: Cell neurobiology
  • NZ3_8: Stem cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Liszewska 

Number of co-investigators in the project: 2

Call: SONATA 6 - announced on 2013-09-16

Amount awarded: 700 000 PLN

Project start date (Y-m-d): 2014-07-11

Project end date (Y-m-d): 2018-07-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (1)
  1. Matricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system
    Authors:
    Anna R. Malik , Ewa Liszewska and Jacek Jaworski
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2015, tom: 9, strony: Artykuł 237), Wydawca: "Frontiers in" journal series
    Status:
    Published
    DOI:
    10.3389/fncel.2015.00237 - link to the publication
  2. Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase.
    Authors:
    Anna R. Malik, Ewa Liszewska, Agnieszka Skalecka, Malgorzata Urbanska, Anand M. Iyer, Lukasz J. Swiech, Malgorzata Perycz, Kamil Parobczak, Patrycja Pietruszka, Malgorzata M. Zarebska, Matylda Macias, Katarzyna Kotulska, Julita Borkowska, Wieslawa Grajkowska, Magdalena E. Tyburczy, Sergiusz Jozwiak, David J. Kwiatkowski, Eleonora Aronica and Jacek Jaworski
    Academic press:
    Acta Neuropathologica Communications (rok: 2015, tom: 3, strony: 48), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s40478-015-0225-z - link to the publication
  3. mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons.
    Authors:
    Skalecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J
    Academic press:
    Developmental Neurobiology (rok: 2016, tom: 76(12), strony: 1308-1327), Wydawca: Wiley Periodicals
    Status:
    Published
    DOI:
    10.1002/dneu.22392 - link to the publication
  4. Adaptor Complex 2 Controls Dendrite Morphology via mTOR-Dependent Expression of GluA2
    Authors:
    Koscielny A, Malik AR, Liszewska E, Zmorzynska J, Tempes A, Tarkowski B, Jaworski J.Koscielny A, Malik AR, Liszewska E, Zmorzynska J, Tempes A, Tarkowski B, Jaworski J.
    Academic press:
    Molecular Neurobiology (rok: 2018, tom: 55, strony: 1590-1606), Wydawca: Springer International Publishing
    Status:
    Published
    DOI:
    10.1007/s12035-017-0436-3 - link to the publication
  5. Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA-derived cell cultures.
    Authors:
    van Scheppingen J, Iyer AM, Prabowo AS, Mühlebner A, Anink JJ, Scholl T, Feucht M, Jansen FE, Spliet WG, Krsek P, Zamecnik J, Buccoliero AM, Giordano F, Genitori L, Kotulska K, Jozwiak S, Jaworski J, Liszewska E, van Vliet EA, Aronica E
    Academic press:
    Glia (rok: 2016, tom: 64(6), strony: 1066-82), Wydawca: Wiley Periodicals
    Status:
    Published
    DOI:
    10.1002/glia.22983 - link to the publication
  1. Neural stem cell dysfunction in human brain disorders
    Authors:
    Ewa Liszewska, Jacek Jaworski
    Book:
    Human Neural Stem Cells (rok: 2018, tom: 66, strony: 283 - 305), Wydawca: Springer International Publishing
    Status:
    Published
    DOI:
    link to the publication

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