Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Sensitivity methods in analysis of biological systems

2013/11/B/ST7/01713

Keywords:

sensitivity analysis signaling pathways therapy optimization

Descriptors:

  • ST7_4: Micro- and nanosystems engineering
  • ST7_3: Simulation engineering and modelling
  • NZ2_9: Systems biology

Panel:

ST7 - Systems and communication engineering: electronics, communication, optoelectronics

Host institution :

Politechnika Śląska, Wydział Automatyki, Elektroniki i Informatyki

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jarosław Śmieja 

Number of co-investigators in the project: 8

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 711 060 PLN

Project start date (Y-m-d): 2014-07-16

Project end date (Y-m-d): 2017-10-15

Project duration:: 39 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer przenośny (7 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (11)
  • Book publications / chapters in book publications (7)
  1. Sensitivity Analysis of Signaling Pathway Models Based on Discrete-Time Measurements
    Authors:
    M. Kardyńska, J. Śmieja
    Academic press:
    Archives of Control Sciences (rok: 2017, tom: 27, strony: 239-250), Wydawca: PAN
    Status:
    Published
    DOI:
    10.1515/acsc-2017-0015 - link to the publication
  2. Sensitivity of combined chemo- and antiangiogenic therapy results in different models describing cancer growth
    Authors:
    M. Dołbniak, M. Kardyńska, J. Śmieja
    Academic press:
    Discrete and Continuous Dynamical Systems - Series B (rok: 2018, tom: 23(1), strony: 145-160), Wydawca: AIMS
    Status:
    Published
    DOI:
    10.3934/dcdsb.2018009 - link to the publication
  3. Development of a population of cancer cells: Observation and modeling by a Mixed Spatial Evolutionary Games approach
    Authors:
    A. Świerniak, M. Krzeslak, S. Student, J. Rzeszowska-Wolny
    Academic press:
    Journal of Theoretical Biology (rok: 2016, tom: 405, strony: 94-103), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jtbi.2016.05.027 - link to the publication
  4. Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level
    Authors:
    M. Kardyńska, A. Paszek, J. Śmieja, D. Spiller, M.R.H. White, W. Widłak, P. Paszek, M. Kimmel
    Academic press:
    PLOS Computational Biology (rok: 2018, tom: 14(4), strony: e1006130), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal. - link to the publication
  5. Adjoint sensitivity analysis of a tumor growth model and its application to spatiotemporal radiotherapy optimization
    Authors:
    K. Fujarewicz, K. Łakomiec
    Academic press:
    Mathematical Biosciences and Engineering (rok: 2016, tom: 13(6), strony: 1131-1142), Wydawca: AIMS
    Status:
    Published
    DOI:
    10.3934/mbe.2016034 - link to the publication
  6. Estimation of initial functions for systems with delays from discrete measurements
    Authors:
    K. Fujarewicz
    Academic press:
    Mathematical Biosciences and Engineering (rok: 2017, tom: 14(1), strony: 165-178), Wydawca: AIMS
    Status:
    Published
    DOI:
    10.3934/mbe.2017011 - link to the publication
  7. Sensitivity of signaling pathway dynamics to plasmid transfection and its consequences
    Authors:
    Śmieja J., Dołbniak M.
    Academic press:
    Mathematical Biosciences and Engineering (rok: 2016, tom: 13(6), strony: 1207-1222), Wydawca: American Institute of Mathematical Sciences
    Status:
    Published
    DOI:
    10.3934/mbe.2016039 - link to the publication
  8. HBK-17, a 5-HT1A receptor ligand with anxiolytic-like activity, preferentially activates ß-arrestin signaling
    Authors:
    K Pytka, M Głuch‐Lutwin, E Żmudzka, K Sałaciak, A Siwek, K Klęczar, M Walczak, M Smolik, A Olczyk, A Galuszka, J Śmieja, B Filipek, J Sapa, M Kołaczkowski, K Pańczyk, AM Waszkielewicz, H Marona
    Academic press:
    Frontiers in Pharmacology (rok: 2018, tom: n.d., strony: n.d.), Wydawca: Fronters Media SA
    Status:
    Submitted
    DOI:
    brak - link to the publication
  9. Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats
    Authors:
    K. Pytka, K. Lustyk, E. Żmudzka, A. Siwek, M. Zygmunt, A. Dziedziczak, J. Śniecikowska, A. Olczyk, A. Gałuszka, J. Smieja, A.M. Waszkielewicz, H. Marona, B. Filipek, J. Sapa, S. Mogilski
    Academic press:
    Frontiers In Pharmacology (rok: 2016, tom: 7, strony: 229), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fphar.2016.00229 - link to the publication
  10. Multidimensional extended spatial evolutionary games
    Authors:
    Krzeslak M, Swierniak A,
    Academic press:
    Computers In Biology and Medicine (rok: 2016, tom: 69, strony: 315-327), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.compbiomed.2015.08.003 - link to the publication
  11. Cancer heterogeneity and multilayer spatial evolutionary games
    Authors:
    A. Świerniak, M. Krześlak
    Academic press:
    Biology Direct (rok: 2016, tom: 11, strony: 53 (1-16)), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13062-016-0156-z - link to the publication
  12. Estimation of non-measurable signals using adjoint sensitivity analysis
    Authors:
    K. Fujarewicz
    Academic press:
    International Journal of Advances in Science Engineering and Technology (rok: 2016, tom: 4(3), strony: 74-77), Wydawca: IRAJ
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Sensitivity analysis of signaling pathways based on frequency distribution of the model step response
    Authors:
    Smieja J, Kardynska M,
    Conference:
    the 12th IASTED International Conference, Biomedical Engineering (BioMed 2016) (rok: 2016, ), Wydawca: IASTED
    Data:
    konferencja Feb 15-16
    Status:
    Published
  2. Variety behavior in the piece-wise linear model of the p53-regulatory module
    Authors:
    Ochab M, Puszynski K, Swierniak A, Klamka J
    Conference:
    International Work-Conference on Bioinformatics and Biomedical Engineering IWBBIO 2017 (rok: 2017, ), Wydawca: Springer
    Data:
    konferencja 26-28.04.2017
    Status:
    Published
  3. Sensitivity of Controllability Conditions for Models of Combined Anticancer Therapy
    Authors:
    Swierniak A, Klamka J
    Conference:
    34th IASTED International Conference on Modelling, Identification and Control (MIC 2015) (rok: 2015, ), Wydawca: IASTED
    Data:
    konferencja Feb. 16-17
    Status:
    Published
  4. Adjoint sensitivity analysis of spatial tumor growth model
    Authors:
    Łakomiec K, Fujarewicz K
    Conference:
    21st National Conference on Applications of Mathematics in Biology and Medicine (rok: 2015, ), Wydawca: Uniwersytet Warszawski
    Data:
    konferencja 22-26.09
    Status:
    Published
  5. Modeling biological effects of radiowaves using evolutionary game theory
    Authors:
    A. Świerniak, M. Krześlak
    Conference:
    2016 IEEE Radio and Antenna Days of the Indian Ocean, RADIO 2016 (rok: 2016, ), Wydawca: IEEE
    Data:
    konferencja 10-13.10.2016
    Status:
    Published
    DOI:
    link to the publication
  6. Sensitivity of switching control systems in the case of fixed terminal state
    Authors:
    Swierniak A, Ochab M, Smieja J
    Conference:
    20 th International Conference on Methods and Models in Automation & Robotics (rok: 2015, ), Wydawca: IEEE
    Data:
    konferencja Aug. 24-27
    Status:
    Published
  7. Analysis of a possible mechanism of noise reduction in biological systems
    Authors:
    Dolbniak M, Smieja J
    Conference:
    XXIII National Conference on Applications Of Mathematics In Biology And Medicine (rok: 2017, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 11-15.09.2017
    Status:
    Published
  8. L1 and L2 norms in sensitivity analysis of signaling pathway models
    Authors:
    M. Kardyńska, J. Śmieja
    Conference:
    21st International Conference on Methods and Models in Automation and Robotics, MMAR 2016 (rok: 2016, ), Wydawca: IEEE
    Data:
    konferencja 29.08-1.09.2016
    Status:
    Published
  9. Analysis of the bifurcation behavior of simple biological production-degradation system with switchings
    Authors:
    Ochab M, Swierniak A, Puszynski K
    Conference:
    XXIII National Conference on Applications Of Mathematics In Biology And Medicine (rok: 2017, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 11-15.09.2017
    Status:
    Published
  10. Attenuation function as an alternative to Hill function in modeling of signaling pathways
    Authors:
    Kardyńska M, Smieja J
    Conference:
    XXIII National Conference on Applications of Mathematics in Biology and Medicine (rok: 2017, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 11-15.09.2017
    Status:
    Published
  11. Pitfalls in finding sloppy and stiff parameters in biochemical models
    Authors:
    Kardynska M, Smieja J
    Conference:
    21st National Conference of Applications of mathematics in biology and medicine (rok: 2015, ), Wydawca: Uniwersytet Warszawski
    Data:
    konferencja 22-26.09
    Status:
    Published
  1. Sloppy/Stiff Parameters Rankings in Sensitivity Analysis of Signaling Pathways.
    Authors:
    Kardynska M, Smieja J, Naumowicz A, Janus P, Widlak P, Kimmel M
    Book:
    Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016) (rok: 2016, tom: 3, strony: 278-283), Wydawca: Science and Technology Publications, Lda
    Status:
    Published
  2. Sprzężona analiza wrażliwości automatów komórkowych
    Authors:
    Łakomiec K, Fujarewicz K
    Book:
    Automatyzacja Procesów Dyskretnych, Teoria i Zastosowania (rok: 2014, tom: II, strony: 173-180), Wydawca: Wydawnictwo Pracowni Komputerowej Jacka Skalmierskiego
    Status:
    Published
  3. Detection and repair of faults in cell cycle - Is it perfect?
    Authors:
    Smieja J, Jaksik R, Swierniak A
    Book:
    Advanced Systems for Automation and Diagnostics (rok: 2015, tom: nd, strony: 63-72), Wydawca: Pomorskie Wydawnictwo Naukowo-Techniczne PWNT
    Status:
    Published
  4. Model predictive control systems in medical applications
    Authors:
    Smieja J, Żabiński K
    Book:
    Automatyzacja Procesów Dyskretnych, Teoria i Zastosowania. (rok: 2014, tom: II, strony: 227-234), Wydawca: Wydawnictwo Pracowni Komputerowej Jacka Skalmierskiego
    Status:
    Published
  5. Sensitivity analysis of signaling pathways in the frequency domain
    Authors:
    M. Kardyńska, J. Śmieja
    Book:
    Advances in Intelligent Systems and Computing (rok: 2016, tom: 472, strony: 275-285), Wydawca: Springer Verlag
    Status:
    Published
  6. Application of adjoint sensitivity analysis to parameter estimation of age-structured model of cell cycle
    Authors:
    M. Jakubczak, K. Fujarewicz
    Book:
    Advances in Intelligent Systems and Computing (rok: 2016, tom: 472, strony: 123-131), Wydawca: Springer Verlag
    Status:
    Published
  7. Influence of the Stochasticity in Threshold Localization on Cell Fate in the PLDE-Model of the P53 Module
    Authors:
    Ochab M, Swierniak A, Klamka J, Puszynski K
    Book:
    Recent Developments and Achievements in Biocybernetics and Biomedical Engineering (rok: 2017, tom: AISC 647, strony: 205-217), Wydawca: Springer
    Status:
    Published

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