Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Pharmacokinetic profiling to understand differences in biological activity of two novel liver-selective NO-releasing compounds V-PYRRO/NO and V-PROLI/NO in the treatment of experimental model of NAFLD in mice

2013/11/N/NZ7/00749

Keywords:

Pharmacokinetics NAFLD hepatic clearance

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Kamil Kuś 

Number of co-investigators in the project: 3

Call: PRELUDIUM 6 - announced on 2013-09-16

Amount awarded: 99 985 PLN

Project start date (Y-m-d): 2014-07-23

Project end date (Y-m-d): 2016-11-22

Project duration:: 28 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer mobilny (4 500 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. Differential effects of liver steatosis on pharmacokinetic profile of two closely related hepatoselective NO-donors; V-PYRRO/NO and V-PROLINO
    Authors:
    K. Kus, E. Kus, A. Zakrzewska , W. Jawien, B. Sitek, M. Walczak, S. Chlopicki
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69, strony: 560-565), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2017.01.031 - link to the publication
  2. Hepatoselective NO-donors, V-PYRRO/NO and V-PROLI/NO in Nonalcoholic Fatty Liver Disease: a Comparison of Anti-Steatotic Effects with the Biotransformation and Pharmacokinetics
    Authors:
    Kamil Kus, Maria Walczak, Edyta Maslak, Agnieszka Zakrzewska, Anna Gonciarz-Dytman, Piotr Zabielski, Barbara Sitek, Krystyna Wandzel, Agnieszka Kij, Adrian Chabowski, Ryan J Holland, Joseph E Saavedra, Larry K Keefer, Stefan Chlopicki
    Academic press:
    Drug Metabolism and Disposition (rok: 2015, tom: 43, strony: 1028-1036), Wydawca: American Society for Pharmacology and Experimental Therapeutics
    Status:
    Published
    DOI:
    10.1124/dmd.115.063388 - link to the publication
  1. Development of LC/MS/MS based targeted metabolomic method to study the effect of carbon monoxide and nitric oxide on endothelial cell metabolism
    Authors:
    Kus K., Kaczara P., Walczak M., Chlopicki S.
    Conference:
    19th International Vascular Biology Meeting (rok: 2016, ), Wydawca: NAVBO
    Data:
    konferencja 30.10-03.11.2016
    Status:
    Published
  2. Ocena wpływu stłuszczenia wątroby na profil farmakokinetyczny dwóch hepatoselektywnych NO-donorów V-PYRRO/NO oraz V-PROLI/NO
    Authors:
    Kuś K., Walczak M., Maślak E., Zakrzewska A., Keefer L.K., Chłopicki S.
    Conference:
    V Konferencja Doktorantów Uniwersytetu Jagiellońskiego - Collegium Medicum (rok: 2015, ), Wydawca: Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego
    Data:
    konferencja 28-29.05.2015
    Status:
    Published
  3. Development of targeted metabolomic profiling of endothelium by LC/MS/MS: A tool to understand endothelial cell metabolism
    Authors:
    Kuś K., Kaczara P., Walczak M., Chlopicki S.
    Conference:
    VII JCET SEMINAR (rok: 2016, ), Wydawca: JMRC
    Data:
    konferencja 19-21.06.2016
    Status:
    Published
  4. Comprehensive pharmacokinetic analysis of two liver-selective NO-donors; a key to understand differences in their pharmacological efficacy against NAFLD
    Authors:
    Kuś K., Walczak M., Maślak E., Zakrzewska A., Keefer L., Chłopicki S
    Conference:
    Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure (rok: 2015, ), Wydawca: Keystone Symposia
    Data:
    konferencja 22-27.03
    Status:
    Published

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