Pharmacokinetic profiling to understand differences in biological activity of two novel liver-selective NO-releasing compounds V-PYRRO/NO and V-PROLI/NO in the treatment of experimental model of NAFLD in mice
2013/11/N/NZ7/00749
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
PRELUDIUM 6 – announced on 2013-09-16
- Amount awarded
- 99 985 PLN
- Project start date
- 2014-07-23
- Project end date
- 2016-11-22
- Project duration
- 28 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Komputer mobilny. Cost: 4 500 PLN
Information in the final report
Publication in academic press/journals (2)
-
Hepatoselective NO-donors, V-PYRRO/NO and V-PROLI/NO in Nonalcoholic Fatty Liver Disease: a Comparison of Anti-Steatotic Effects with the Biotransformation and Pharmacokinetics
- Authors:
- Kamil Kus, Maria Walczak, Edyta Maslak, Agnieszka Zakrzewska, Anna Gonciarz-Dytman, Piotr Zabielski, Barbara Sitek, Krystyna Wandzel, Agnieszka Kij, Adrian Chabowski, Ryan J Holland, Joseph E Saavedra, Larry K Keefer, Stefan Chlopicki
- Academic press:
- Drug Metabolism and Disposition (year: 2015, volume: 43, pages: 1028-1036), Publisher: American Society for Pharmacology and Experimental Therapeutics
- Status:
- Published
- DOI:
- 10.1124/dmd.115.063388 – link to the publication
-
Differential effects of liver steatosis on pharmacokinetic profile of two closely related hepatoselective NO-donors; V-PYRRO/NO and V-PROLINO
- Authors:
- K. Kus, E. Kus, A. Zakrzewska , W. Jawien, B. Sitek, M. Walczak, S. Chlopicki
- Academic press:
- Pharmacological Reports (year: 2017, volume: 69, pages: 560-565), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.pharep.2017.01.031 – link to the publication
Articles in post-conference publications (4)
-
Development of targeted metabolomic profiling of endothelium by LC/MS/MS: A tool to understand endothelial cell metabolism
- Authors:
- Kuś K., Kaczara P., Walczak M., Chlopicki S.
- Conference:
- VII JCET SEMINAR (year: 2016, pages: 28), Publisher: JMRC
- Date:
- conference 19-21.06.2016
- Status:
- Published
-
Ocena wpływu stłuszczenia wątroby na profil farmakokinetyczny dwóch hepatoselektywnych NO-donorów V-PYRRO/NO oraz V-PROLI/NO
- Authors:
- Kuś K., Walczak M., Maślak E., Zakrzewska A., Keefer L.K., Chłopicki S.
- Conference:
- V Konferencja Doktorantów Uniwersytetu Jagiellońskiego - Collegium Medicum (year: 2015, pages: xxx), Publisher: Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego
- Date:
- conference 28-29.05.2015
- Status:
- Published
-
Comprehensive pharmacokinetic analysis of two liver-selective NO-donors; a key to understand differences in their pharmacological efficacy against NAFLD
- Authors:
- Kuś K., Walczak M., Maślak E., Zakrzewska A., Keefer L., Chłopicki S
- Conference:
- Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure (year: 2015, pages: X8 2022), Publisher: Keystone Symposia
- Date:
- conference 22-27.03
- Status:
- Published
-
Development of LC/MS/MS based targeted metabolomic method to study the effect of carbon monoxide and nitric oxide on endothelial cell metabolism
- Authors:
- Kus K., Kaczara P., Walczak M., Chlopicki S.
- Conference:
- 19th International Vascular Biology Meeting (year: 2016, pages: T119), Publisher: NAVBO
- Date:
- conference 30.10-03.11.2016
- Status:
- Published