Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Proteome, lipidome and miRN-ome of exosomes relased from head and neck cancer cells in response to genotoxic agents

2013/11/B/NZ7/01512

Keywords:

proteome lipidome miRN-ome exosomes quantitative proteomics radiotherapy chemotherapy

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases
  • NZ7_2: Environment and health risks

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Centrum Onkologii - Instytut im. Marii Skłodowskiej - Curie, oddział w Gliwicach

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Monika Pietrowska 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 897 000 PLN

Project start date (Y-m-d): 2014-07-03

Project end date (Y-m-d): 2019-01-02

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Rotor wychylny S-4-72 z 4 pojemnikami okrągłymi 250 mL oraz adapterami.
  2. Lodówko-zamrażarka.

Information in the final report

  • Publication in academic press/journals (8)
  • Book publications / chapters in book publications (2)
  1. Harmonization of exosome isolation from culture supernatants for optimized proteomics analysis
    Authors:
    Abramowicz A, Marczak L, Wojakowska A, Zapotoczny S, Whiteside TL, Widlak P, Pietrowska M.
    Academic press:
    Plos One (rok: 2018, tom: Oct 31;13(10), strony: 45306), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0205496 - link to the publication
  2. MicroRNA Profile of Exosomes and Parental Cells is Differently Affected by Ionizing Radiation
    Authors:
    Agata Abramowicz, Wojciech Łabaj, Justyna Mika, Katarzyna Szołtysek, Izabella Ślęzak Prochazka, Łukasz Mielańczyk, Michael D. Story, Monika Pietrowska, Andrzej Polański and Piotr Widłak
    Academic press:
    Radiation Research (rok: 2020, tom: 194, strony: 133-142), Wydawca: Radiation Research Society
    Status:
    Published
    DOI:
    10.1667/RADE-20-00007 - link to the publication
  3. Proteome Profiling of Exosomes Purified from a Small Amount of Human Serum: The Problem of Co-Purified Serum Components
    Authors:
    Mateusz Smolarz, Monika Pietrowska, Natalia Matysiak, Łukasz Mielańczyk and Piotr Widłak
    Academic press:
    Proteomes (rok: 2019, tom: 7, strony: 45303), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/proteomes7020018 - link to the publication
  4. Proteomes of exosomes from HPV(+) or HPV(-) Head and Neck Cancer cells: differential enrichment in immunoregulatory proteins.
    Authors:
    Sonja Ludwig, Lukasz Marczak, Priyanka Sharma, Agata Abramowicz, Marta Gawin, Piotr Widlak, Theresa L. Whiteside, Monika Pietrowska
    Academic press:
    OncoImmunology (rok: 2019, tom: VOL. 8, NO. 7, strony: e1593808), Wydawca: Taylor & Francis Inc.
    Status:
    Published
    DOI:
    10.1080/2162402X.2019.1593808 - link to the publication
  5. The Influence of Ionizing Radiation on Exosome Composition, Secretion and Intercellular Communication
    Authors:
    Jelonek K, Widlak P, Pietrowska M
    Academic press:
    Protein and Peptide Letters (rok: 2016, tom: 23(7), strony: 656-63), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    brak - link to the publication
  6. Ionizing radiation affects the composition of the proteome of extracellular vesicles released by head-and-neck cancer cells in vitro.
    Authors:
    Agata Abramowicz, Anna Wojakowska, Lukasz Marczak, Malgorzata Lysek-Gladysinska, Mateusz Smolarz, Michael D Story, Joanna Polanska, Piotr Widlak and Monika Pietrowska
    Academic press:
    Journal of Radiation Research (rok: 2019, tom: -, strony: 1–9), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/jrr/rrz001 - link to the publication
  7. Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma.
    Authors:
    Jelonek K, Wojakowska A, Marczak L, Muer A, Tinhofer-Keilholz I, Lysek-Gladysinska M, Widlak P, Pietrowska M
    Academic press:
    Acta Biochim Pol. (rok: 2015, tom: 62(2), strony: 265-72), Wydawca: The Journal of the Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2015_970 - link to the publication
  8. Proteomic analysis of exosomal cargo: the challenge of high purity vesicle isolation.
    Authors:
    Abramowicz A, Widlak P, Pietrowska M
    Academic press:
    Molecular BioSystems (rok: 2016, tom: 12(5), strony: 1407-19), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6mb00082g - link to the publication
  1. Isolation of exosomes for the purposes of protein cargo analysis with the use of mass spectrometry.
    Authors:
    Pietrowska M, Funk S, Gawin M, Marczak Ł, Abramowicz A, Widłak P, Whiteside T
    Book:
    Functional Genomics, Proteomics of Exosomes (rok: 2017, tom: Third Edition, strony: 291-307), Wydawca: Springer Science and Business Media
    Status:
    Published
  2. MS-based proteomic analysis of serum and plasma – problem of high abundant components; lights and shadows of albumin removal
    Authors:
    Pietrowska M, Wlosowicz A, Gawin M, Widlak P
    Book:
    Proteomics, Metabolomics, Interactomics and Systems Biology (rok: 2019, tom: 1073, strony: 57-76), Wydawca: Springer Nature Switzerland AG
    Status:
    Published

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