Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Protection of hematopoietic stem cells from premature aging - classical and non-classical role of heme oxygenase 1.

2013/11/N/NZ3/00956

Keywords:

hematopoietic stem cells aging heme oxygenase 1 carbon monoxide mesenchymal stem cells DNA repair

Descriptors:

  • NZ3_4: Ageing
  • NZ3_8: Stem cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Krzysztof Szade 

Number of co-investigators in the project: 2

Call: PRELUDIUM 6 - announced on 2013-09-16

Amount awarded: 99 996 PLN

Project start date (Y-m-d): 2014-07-11

Project end date (Y-m-d): 2016-07-10

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Book publications / chapters in book publications (2)
  1. Adult stem cells: hopes and hypes of regenerative medicine
    Authors:
    Józef Dulak, Krzysztof Szade, Agata Szade, Witold Nowak and Alicja Józkowicz
    Academic press:
    Acta Biochimica Polonica (rok: 2015, tom: 62(3), strony: 329-337), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2015_1023 - link to the publication
  2. Heme oxygenase-1 deficiency in the niche triggers premature aging of hematopoietic stem cells.
    Authors:
    Krzysztof Szade*, Monika Zukowska, Agata Szade, Witold Nowak, Maciej Ciesla, Karolina Bukowska-Strakova, Gunsagar Singh Gulati, Neli Kachamakova-Trojanowska, Anna Kusienicka, Elisa Einwallner, Jacek Kijowski, Szymon Czauderna, Harald Esterbauer, Jozef Dulak, Alicja Jozkowicz
    Academic press:
    Cell Reports , Wydawca: Cell Press
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Generation of functional endothelial cells with progenitor-like features from murine induced pluripotent stem cells
    Authors:
    Kachamakova-Trojanowska N, Nowak W, Szade K, Stepniewski J, Bukowska-Strakova K, Zukowska M, Taha H, Chmura-Skirlinska A, Beilharz M, Dulak J, Jozkowicz A
    Academic press:
    Vascular Pharmacology (rok: 2016, tom: 86, strony: 94-108), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.vph.2016.07.008 - link to the publication
  4. Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes granulocytes and hematopoietic stem cells to the blood
    Authors:
    Agata Szade, Krzysztof Szade, Witold N. Nowak, Karolina Bukowska- Strakova, Lucie Muchova, Maciej Cieśla, Neli Kachamakova-Trojanowska, Marzena Rams-Baron, Alicja Ratuszna, Józef Dulak, Alicja Józkowicz
    Academic press:
    Cell Reports , Wydawca: Cell Press
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Analysis of cell cycle status of murine hematopoietic stem cells
    Authors:
    Krzysztof Szade, Karolina Bukowska-Strakova, Monika Zukowska, Alicja Jozkowicz, Józef Dulak
    Book:
    Methods in Molecular Biology - Stem Cells Dynamics and Heterogeneity (rok: 2016, tom: 1516, strony: 91-99), Wydawca: Springer Protocols
    Status:
    Published
  2. Measuring ATP concentration in small number of murine hematopoietic stem cells
    Authors:
    Krzysztof Szade, Monika Zukowska, Alicja Jozkowicz, Józef Dulak
    Book:
    Methods in Molecular Biology - Stem Cells Dynamics and Heterogeneity (rok: 2016, tom: 1516, strony: 205-217), Wydawca: Springer Protocols
    Status:
    Published

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