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The role of cholinergic anti-inflammatory pathway in the preventing of negative effect of inflammation on the GnRH/LH secretion in the follicular phase ewes

2013/11/B/NZ9/01848

Keywords

Descriptors

  • NZ9_2: Naukowe podstawy zootechniki

Panel

NZ9 – Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution

Instytut Fizjologii i Żywienia Zwierząt im. Jana Kielanowskiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Andrzej Przemysław Herman

Number of co-investigators in the project: 7

Call

OPUS 6 – announced on 2013-09-16

Amount awarded
733 000 PLN
Project start date
2014-07-23
Project end date
2018-01-22
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Inkubator z wytrząsanie. Cost: 37 800 PLN

Information in the final report

Publication in academic press/journals (2)

  1. Peripheral inhibitor of AChE, neostigmine, prevents the inflammatory dependent suppression of GnRH/LH secretion during the Follicular phase of the estrous cycle

    Authors:
    Herman A.P., Skipor J., Krawczyńska A., Bochenek J., Wojtulewicz K., Antushevich H., Herman A., Paczesna K., Romanowicz K., Tomaszewska-Zaremba D
    Academic press:
    BioMedResearch International (year: 2017, volume: 2017, pages: 6823209), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/6823209 – link to the publication

  2. Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide- Induced Systemic Inflammation

    Authors:
    Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor
    Academic press:
    Mediators of Inflammation (year: 2018, volume: 2018, pages: Article ID 9150207,), Publisher: HINDAWI LTD
    Status:
    Published
    DOI:
    10.1155/2018/9150207 – link to the publication

Articles in post-conference publications (5)

  1. Donepezil reduces the LPS-induced suppression of GnRH synthesis in the hypothalamus of ewe during the follicular phase of the estrous cycle

    Authors:
    Herman A.P., Skipor J., Bochenek J., Kopycińska K., Król K., Antushevich H., Krawczyńska A., Tomaszewska – Zaremba D.
    Conference:
    The 4rd Winter Workshop of the Society for Biology of Reproduction Central and Local Regulations of Reproductive Processes (year: 2016, pages: 49), Publisher: Oddział Krakowski Towarzystwa Biologii Rozrodu
    Date:
    conference 3-5.02.2016
    Status:
    Published

  2. Effect of central injection of donepezil on the bacterial endotoxin induced suppression of GnRH/LH secretion in ewes during the follicular phase of the estrous cycle

    Authors:
    Herman AP, Skipor J, Król K, Bochenek J, Krawczyńska A, Antushevich A, Kopycińska K, Romanowicz K, Tomaszewska-Zaremba D
    Conference:
    VIII Zjazd Towarzystwa Biologii Rozrodu (year: 2017, pages: 125), Publisher: Towarzystwo Biologii Rozrodu
    Date:
    conference 7-9 września 2017
    Status:
    Published

  3. Central injection of donepezil influences lipopolysaccharide-induced synthesis of pro-inflammatory cytokines and gene expression of their receptor in the hypothalamus of ewes

    Authors:
    Tomczyk M., Skipor J., Antushevich A., Krawczyńska A., Bochenek J., Wojtulewicz K., Tomaszewska-Zaremba D., Herman AP.
    Conference:
    XIVth International Conference of Young Researchers Physiology and Biochemistry in Animal Nutrition (year: 2017, pages: 68), Publisher: Instytut Fizjologii i Żywienia Zwierząt im. Jana Kielanowskiego PAN
    Date:
    conference 14–15 września2017
    Status:
    Published

  4. Effect of acetylcholinesterase blocking on mRNA expression of pattern recognition receptors, pro-inflammatory cytokines and their receptors in the ovine choroid plexus under basal and LPS-challenged conditions

    Authors:
    Kowalewska M., Szczepkowska A., Oleszkiewicz M., Herman A.P., Skipor J.
    Conference:
    19th International Symposium on Signal Transduction at the Blood-Brain Barriers (year: 2016, pages: 35), Publisher: University of Copenhagen
    Date:
    conference 14-16.09.2016
    Status:
    Published

  5. The effect of Donepezil and Neostigmine on the gene expression of proinflammatory cytokines and their receptors in the preoptic area of follicular phase ewes during peripheral acute inflammation

    Authors:
    Krawczyńska A., Wójcik M., Kopycińska K., Skipor J., Bochenek J., Król K., Antushevich H., Tomaszewska-Zaremba D., Herman A.P.
    Conference:
    Physiology and Biochemistry in Animal Nutrition (year: 2016, pages: 42), Publisher: Instytut Fizjologii i Żywienia Zwierząt im. Jana Kielanowskiego PAN
    Date:
    conference 27-28.09.2016
    Status:
    Published

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