Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Behavioral and biochemical evaluation of mephedrone's action and interaction with other psychoactive drugs

2013/11/B/NZ7/04837

Keywords:

mephedrone psychostymulants cannabinoids behavioral effects oxidative stress dopamine transporter serotonin transporter

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grażyna Biała 

Number of co-investigators in the project: 4

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 522 900 PLN

Project start date (Y-m-d): 2014-07-04

Project end date (Y-m-d): 2018-01-03

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Homogenizator X-360 (3750) + Wałek śr. 6mm do homogenizatora X-360 (2400) (6 000 PLN)
  2. Aktymetry - aparatura od pomiaru aktywmości lokomotorycznej myszy (110 000 PLN)
  3. Program Graphpad Prism (2 372 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (14)
  1. Acute MDMA and Nicotine Co-administration: Behavioral Effects and Oxidative Stress Processes in Mice
    Authors:
    Barbara Budzynska, Artur Wnorowski, Katarzyna Kaszubska, Grazyna Biala, Marta Kruk-Słomka, Jacek Kurzepa and Anna Boguszewska-Czubara
    Academic press:
    Frontiers in Behavioral Neuroscience (rok: 2018, tom: 12, strony: 45301), Wydawca: Frontiers in Behavioral Neuroscience
    Status:
    Published
    DOI:
    10.3389/fnbeh.2018.00149 - link to the publication
  2. Potential pro-oxidative effects of single dose of mephedrone in vital organs of mice
    Authors:
    Piotr Tarkowskia, Krzysztof Jankowski, Barbara Budzynska, Grazyna Biała, Anna Boguszewska-Czubara
    Academic press:
    Pharmacological Reports (rok: 2018, tom: 70, strony: 1097–1104), Wydawca: Elsevier
    Status:
    Published
  3. Acute behavioral effects of co-administration of mephedrone and MDMA in mice.
    Authors:
    Budzynska B, Michalak A, Frankowska M, Kaszubska K, Biala G
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69, strony: 199-205), Wydawca: Elsevier
    Status:
    Published
  4. Mephedrone and nicotine: oxidative stress and behavioral interactions in animal models.
    Authors:
    Barbara Budzynska, Anna Boguszewska-Czubara, Marta Kruk-Slomka, Jacek Kurzepa, Grazyna Biala
    Academic press:
    Neurochemical Research (rok: 2015, tom: 40, strony: 1083-1093), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-015-1566-5 - link to the publication
  1. Behawioralne efekty łącznego podania nikotyny i MDMA w zwierzęcych modelach doświadczalnych
    Authors:
    Katarzyna Kaszubska, Grazyna Biala, Barbara Budzynska
    Conference:
    IX Interdyscyplinarna Konferencja Naukowa Tygiel 2017: Interdyscyplinarność kluczem do rozwoju, Lublin (rok: 2017, ), Wydawca: -
    Data:
    konferencja 18-19.03.
    Status:
    Published
  2. Long lasting effects of subchronic administration of mephedrone with MDMA in mice.
    Authors:
    Grazyna Biala, Marta Kruk-Slomka, Agnieszka Michalak, Barbara Budzynska
    Conference:
    European Brain Behaviour Society & European Behavioural Pharmacology Society Joint Meeting, Verona, Italy (rok: 2015, ), Wydawca: EBBS
    Data:
    konferencja September 12-15
    Status:
    Published
  3. Behawioralne efekty łącznego podania mefedronu i MDMA w zwierzęcych modelach doświadczalnych
    Authors:
    Katarzyna Kaszubska, Barbara Budzynska, Karolina Pekala, Grazyna Biala
    Conference:
    Badania i Rozwój Mlodych Naukowców w Polsce, Będlewo (rok: 2017, ), Wydawca: -
    Data:
    konferencja 23-24.02.
    Status:
    Published
  4. Does mephedrone affect cognitive processes by altering the activity of extracellular matrix metalloproteinases
    Authors:
    Anna Boguszewska-Czubara, Karolina Grot, Jacek Kurzepa, Grazyna Biala, Barbara Budzynska
    Conference:
    XX International Symposium :Advances in the Chemistry of Heteroorganic Compounds and XVII International Symposium on Selected Problems of Chemistry of Acyclic and Cyclic Heteroorganic Compounds, Łódź (rok: 2017, ), Wydawca: -
    Data:
    konferencja 23-24.11.
    Status:
    Published
  5. Mephedrone exposure in male Swiss mice: damages and possible solutions to address drug addiction.
    Authors:
    S. Silvestro, Anna Boguszewska-Czubara, Jacek Kurzepa, Grazyna Biala, Karolina Grot, C. Faggio, Barbara Budzynskaa
    Conference:
    90th SIBS National Congress on Experimenatl Biology in basic and applied research to the environment and human health.Trapani, Italy (rok: 2017, ), Wydawca: -
    Data:
    konferencja 27-28.10.
    Status:
    Published
  6. The influence of co-administation of MDMA and nicotine on cognitive processes and the nicotine-induced behavioral sensitization.
    Authors:
    Katarzyna Kaszubska, Barbara Budzynska, Anna Boguszewska-Czubara, Marta Kruk-Slomka, Artur Wnorowski, Jacek Kurzepa, Grazyna Biala
    Conference:
    5th International Conference and Workshop: Plant-the source of research material, Lublin (rok: 2017, ), Wydawca: LTWNF i Polichymia Lublin
    Data:
    konferencja 21-24.06.
    Status:
    Published
  7. The influence of co-administration of mephedrone and nicotine on anxiety- and memory-related behaviours and nicoitne-induced sensitization in mice.
    Authors:
    Grazyna Biala, Katarzyna Kaszubska, Marta Kruk-Slomka, Agnieszka Michalak, Barbara Budzynska
    Conference:
    30th European Congress of Neuropsychopharmacology, Paryż (rok: 2017, ), Wydawca: ECNP
    Data:
    konferencja 2-5.09.
    Status:
    Published
  8. Wpływ łącznego podania mefedronu i nikotyny na zachowania lękowe i sensytyzację na efekty lokomotoryczne oceniane w zwierzęcych modelach doświadczalnych.
    Authors:
    Kaszubska K, Budzynska B, Biala G.
    Conference:
    VII Lubelskie Sympozjum Doktorantow Nauk Farmaceutycznych wraz z otwartym Seminarium Nauk o Życiu, Lublin (rok: 2016, ), Wydawca: LSDNF
    Data:
    konferencja 19.04.
    Status:
    Published
  9. Co-administration of mephedrone and MDMA-behavioral interactions.
    Authors:
    Biala G, Kruk-Slomka M, Michalak A, Budzynska B.
    Conference:
    10th FENS Forum of Neuroscience, Copenhagen, Denmark (rok: 2016, ), Wydawca: FENS
    Data:
    konferencja July 2-6
    Status:
    Published
  10. Subchronic administration of mephedrone - long lasting behavioural effects.
    Authors:
    Grazyna Biala, Marta Kruk-Slomka, Agnieszka Michalak, Barbara Budzynska
    Conference:
    4th International Conference and Workshop Plant-the source of research material. (rok: 2015, ), Wydawca: -
    Data:
    konferencja 20-23.09.
    Status:
    Published
  11. The influence of mephedrone on nicotine-induced sensitization in mice; behavioral and biochemical impact.
    Authors:
    Grazyna Biala, Anna Boguszewska-Czubara, Karolina grot, Katarzyna Kaszubska, Agnieszka Michalak, Karolina Pekala, Marta Kruk-Slomka, Barbara Budzynska
    Conference:
    5th International Conference and Workshop: Plant-the source of research materials, Lublin (rok: 2017, ), Wydawca: LTWNF i Polichymia Lublin
    Data:
    konferencja 21-24.06.
    Status:
    Published
  12. Long lasting effects of acute administration of mephedrone.
    Authors:
    Barbara Budzynska, Marta Kruk-Slomka, Agnieszka Michalak, Grazyna Biala
    Conference:
    International Conference Pharmacy today and tomorrow-theory and practice (rok: 2015, ), Wydawca: -
    Data:
    konferencja 11-12.06.
    Status:
    Published
  13. Wplyw jednorazowego podania mefedronu, MDMA i amfetaminy na zachowania depresyjne u myszy
    Authors:
    Katarzyna Kaszubska, Izabela Banaszkiewicz, Joanna Kowalczyk, Barbara Budzynska, Grazyna Biala
    Conference:
    International Conference of Natural and Medical Sciences: Young Scientists, PhD Students and Students, Lublin (rok: 2017, ), Wydawca: MEDtube Science, supplement, Issue 4/2017
    Data:
    konferencja 1-3 grudnia
    Status:
    Published
  14. Wpływ metaloproteinaz macierzy zewnątrzkomórkowej na procesy kognitywne indukowane subchronicznym podaniem mefedronu.
    Authors:
    Anna Boguszewska-Czubara, Karolina Grot, Jacek Kurzepa, Grazyna Biala, Barbara Budzynska
    Conference:
    III Sypozjum: Szkoła Chemii Medycznej, Wrocław (rok: 2017, ), Wydawca: -
    Data:
    konferencja 6-8.09.
    Status:
    Published