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Behavioral and biochemical evaluation of mephedrone's action and interaction with other psychoactive drugs

2013/11/B/NZ7/04837

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ7_15: Toksykologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Voivodeship: lubelskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Grażyna Biała

Number of co-investigators in the project: 4

Call

OPUS 6 – announced on 2013-09-16

Amount awarded
522 900 PLN
Project start date
2014-07-04
Project end date
2018-01-03
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Aktymetry - aparatura od pomiaru aktywmości lokomotorycznej myszy. Cost: 110 000 PLN
  2. Homogenizator X-360 (3750) + Wałek śr. 6mm do homogenizatora X-360 (2400). Cost: 6 000 PLN
  3. Program Graphpad Prism. Cost: 2 372 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Acute behavioral effects of co-administration of mephedrone and MDMA in mice.

    Authors:
    Budzynska B, Michalak A, Frankowska M, Kaszubska K, Biala G
    Academic press:
    Pharmacological Reports (year: 2017, volume: 69, pages: 199-205), Publisher: Elsevier
    Status:
    Published

  2. Mephedrone and nicotine: oxidative stress and behavioral interactions in animal models.

    Authors:
    Barbara Budzynska, Anna Boguszewska-Czubara, Marta Kruk-Slomka, Jacek Kurzepa, Grazyna Biala
    Academic press:
    Neurochemical Research (year: 2015, volume: 40, pages: 1083-1093), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-015-1566-5 – link to the publication

  3. Acute MDMA and Nicotine Co-administration: Behavioral Effects and Oxidative Stress Processes in Mice

    Authors:
    Barbara Budzynska, Artur Wnorowski, Katarzyna Kaszubska, Grazyna Biala, Marta Kruk-Słomka, Jacek Kurzepa and Anna Boguszewska-Czubara
    Academic press:
    Frontiers in Behavioral Neuroscience (year: 2018, volume: 12, pages: 46032), Publisher: Frontiers in Behavioral Neuroscience
    Status:
    Published
    DOI:
    10.3389/fnbeh.2018.00149 – link to the publication

  4. Potential pro-oxidative effects of single dose of mephedrone in vital organs of mice

    Authors:
    Piotr Tarkowskia, Krzysztof Jankowski, Barbara Budzynska, Grazyna Biała, Anna Boguszewska-Czubara
    Academic press:
    Pharmacological Reports (year: 2018, volume: 70, pages: 1097–1104), Publisher: Elsevier
    Status:
    Published

Articles in post-conference publications (14)

  1. The influence of co-administation of MDMA and nicotine on cognitive processes and the nicotine-induced behavioral sensitization.

    Authors:
    Katarzyna Kaszubska, Barbara Budzynska, Anna Boguszewska-Czubara, Marta Kruk-Slomka, Artur Wnorowski, Jacek Kurzepa, Grazyna Biala
    Conference:
    5th International Conference and Workshop: Plant-the source of research material, Lublin (year: 2017, pages: 79), Publisher: LTWNF i Polichymia Lublin
    Date:
    conference 21-24.06.
    Status:
    Published

  2. Mephedrone exposure in male Swiss mice: damages and possible solutions to address drug addiction.

    Authors:
    S. Silvestro, Anna Boguszewska-Czubara, Jacek Kurzepa, Grazyna Biala, Karolina Grot, C. Faggio, Barbara Budzynskaa
    Conference:
    90th SIBS National Congress on Experimenatl Biology in basic and applied research to the environment and human health.Trapani, Italy (year: 2017, pages: 5), Publisher: -
    Date:
    conference 27-28.10.
    Status:
    Published

  3. Does mephedrone affect cognitive processes by altering the activity of extracellular matrix metalloproteinases

    Authors:
    Anna Boguszewska-Czubara, Karolina Grot, Jacek Kurzepa, Grazyna Biala, Barbara Budzynska
    Conference:
    XX International Symposium :Advances in the Chemistry of Heteroorganic Compounds and XVII International Symposium on Selected Problems of Chemistry of Acyclic and Cyclic Heteroorganic Compounds, Łódź (year: 2017, pages: 163), Publisher: -
    Date:
    conference 23-24.11.
    Status:
    Published

  4. Behawioralne efekty łącznego podania nikotyny i MDMA w zwierzęcych modelach doświadczalnych

    Authors:
    Katarzyna Kaszubska, Grazyna Biala, Barbara Budzynska
    Conference:
    IX Interdyscyplinarna Konferencja Naukowa Tygiel 2017: Interdyscyplinarność kluczem do rozwoju, Lublin (year: 2017, pages: 46-47), Publisher: -
    Date:
    conference 18-19.03.
    Status:
    Published

  5. Subchronic administration of mephedrone - long lasting behavioural effects.

    Authors:
    Grazyna Biala, Marta Kruk-Slomka, Agnieszka Michalak, Barbara Budzynska
    Conference:
    4th International Conference and Workshop Plant-the source of research material. (year: 2015, pages: 72-72), Publisher: -
    Date:
    conference 20-23.09.
    Status:
    Published

  6. Wplyw jednorazowego podania mefedronu, MDMA i amfetaminy na zachowania depresyjne u myszy

    Authors:
    Katarzyna Kaszubska, Izabela Banaszkiewicz, Joanna Kowalczyk, Barbara Budzynska, Grazyna Biala
    Conference:
    International Conference of Natural and Medical Sciences: Young Scientists, PhD Students and Students, Lublin (year: 2017, pages: 140), Publisher: MEDtube Science, supplement, Issue 4/2017
    Date:
    conference 1-3 grudnia
    Status:
    Published

  7. Long lasting effects of acute administration of mephedrone.

    Authors:
    Barbara Budzynska, Marta Kruk-Slomka, Agnieszka Michalak, Grazyna Biala
    Conference:
    International Conference Pharmacy today and tomorrow-theory and practice (year: 2015, pages: 79-79), Publisher: -
    Date:
    conference 11-12.06.
    Status:
    Published

  8. The influence of mephedrone on nicotine-induced sensitization in mice; behavioral and biochemical impact.

    Authors:
    Grazyna Biala, Anna Boguszewska-Czubara, Karolina grot, Katarzyna Kaszubska, Agnieszka Michalak, Karolina Pekala, Marta Kruk-Slomka, Barbara Budzynska
    Conference:
    5th International Conference and Workshop: Plant-the source of research materials, Lublin (year: 2017, pages: 52), Publisher: LTWNF i Polichymia Lublin
    Date:
    conference 21-24.06.
    Status:
    Published

  9. Behawioralne efekty łącznego podania mefedronu i MDMA w zwierzęcych modelach doświadczalnych

    Authors:
    Katarzyna Kaszubska, Barbara Budzynska, Karolina Pekala, Grazyna Biala
    Conference:
    Badania i Rozwój Mlodych Naukowców w Polsce, Będlewo (year: 2017, pages: 33), Publisher: -
    Date:
    conference 23-24.02.
    Status:
    Published

  10. Co-administration of mephedrone and MDMA-behavioral interactions.

    Authors:
    Biala G, Kruk-Slomka M, Michalak A, Budzynska B.
    Conference:
    10th FENS Forum of Neuroscience, Copenhagen, Denmark (year: 2016, pages: 22), Publisher: FENS
    Date:
    conference July 2-6
    Status:
    Published

  11. The influence of co-administration of mephedrone and nicotine on anxiety- and memory-related behaviours and nicoitne-induced sensitization in mice.

    Authors:
    Grazyna Biala, Katarzyna Kaszubska, Marta Kruk-Slomka, Agnieszka Michalak, Barbara Budzynska
    Conference:
    30th European Congress of Neuropsychopharmacology, Paryż (year: 2017, pages: P.6.c001), Publisher: ECNP
    Date:
    conference 2-5.09.
    Status:
    Published

  12. Wpływ metaloproteinaz macierzy zewnątrzkomórkowej na procesy kognitywne indukowane subchronicznym podaniem mefedronu.

    Authors:
    Anna Boguszewska-Czubara, Karolina Grot, Jacek Kurzepa, Grazyna Biala, Barbara Budzynska
    Conference:
    III Sypozjum: Szkoła Chemii Medycznej, Wrocław (year: 2017, pages: 51), Publisher: -
    Date:
    conference 6-8.09.
    Status:
    Published

  13. Wpływ łącznego podania mefedronu i nikotyny na zachowania lękowe i sensytyzację na efekty lokomotoryczne oceniane w zwierzęcych modelach doświadczalnych.

    Authors:
    Kaszubska K, Budzynska B, Biala G.
    Conference:
    VII Lubelskie Sympozjum Doktorantow Nauk Farmaceutycznych wraz z otwartym Seminarium Nauk o Życiu, Lublin (year: 2016, pages: 42-43), Publisher: LSDNF
    Date:
    conference 19.04.
    Status:
    Published

  14. Long lasting effects of subchronic administration of mephedrone with MDMA in mice.

    Authors:
    Grazyna Biala, Marta Kruk-Slomka, Agnieszka Michalak, Barbara Budzynska
    Conference:
    European Brain Behaviour Society & European Behavioural Pharmacology Society Joint Meeting, Verona, Italy (year: 2015, pages: 55-55), Publisher: EBBS
    Date:
    conference September 12-15
    Status:
    Published

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