Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The significance of the serotonergic innervation of the brain hypothalamus in the regulation of cytochrome P450

2013/11/B/NZ7/04897

Keywords:

brain hypothalamus paraventricular nucleus arcuate nucleus serotonergic receptors hormones liver cytochrome P450

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Władysława Daniel 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 939 744 PLN

Project start date (Y-m-d): 2014-07-22

Project end date (Y-m-d): 2017-12-21

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw HPLC (High - Performance Liquid Chromatography) UltiMate 3000 wraz z detektorem elektrochemicznym TCD-3000 RS (260 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (5)
  1. The reverse role of the hypothalamic paraventricular (PVN) and arcuate (ARC) nuclei in the central serotonergic regulation of the liver cytochrome P450 isoform CYP2C11
    Authors:
    Marta Rysz, Ewa Bromek, Anna Haduch, Barbora Liskova, Jacek Wójcikowski, Władysława A. Daniel
    Academic press:
    Biochemical Pharmacology (rok: 2016, tom: 112, strony: 82-89), Wydawca: Elsevier, Amsterdam, Holandia
    Status:
    Published
    DOI:
    10.1016/j.bcp.2016.04.017 - link to the publication
  2. Stimulation of 5-HT2C serotonin receptor subtype in the hypothalamic arcuate nuclei (ARC) increases the cytochrome P450 activity in the liver
    Authors:
    Ewa Bromek, Marta Rysz, Anna Haduch and Władysława A. Daniel
    Academic press:
    Pharmacological Reports (rok: 2019, tom: 71, strony: brak), Wydawca: Elsevier Sp. z o.o., Warszawa, Polska
    Status:
    Accepted for publication
    DOI:
    10.1016/j.pharep.2019.05.010 - link to the publication
  3. Activation of 5-HT1A receptors in the hypothalamic paraventricular nuclei negatively regulates cytochrome P450 expression and activity in rat liver
    Authors:
    Ewa Bromek, Marta Rysz, Anna Haduch, Jacek Wójcikowski, Władysława A. Daniel
    Academic press:
    Drug Metabolism and Disposition (rok: 2018, tom: 46, strony: 786-793), Wydawca: The American Society for Pharmacology and Experimental Therapeutics, Bethesda
    Status:
    Published
    DOI:
    10.1124/dmd.117.079632 - link to the publication
  4. Serotonin receptors of 5-HT2 type in the hypothalamic arcuate nuclei positively regulate liver cytochrome P450 via stimulation of the growth hormone-releasing hormone/growth hormone hormonal pathway
    Authors:
    Ewa Bromek, Marta Rysz, Anna Haduch and Władysława A. Daniel
    Academic press:
    Drug Metabolism and Disposition (rok: 2019, tom: 47, strony: 80-85), Wydawca: The American Society for Pharmacology and Experimental Therapeutics, Bethesda
    Status:
    Published
    DOI:
    10.1124/dmd.118.083808 - link to the publication
  1. The effect of serotonergic innervation of the hypothalamus on the regulation of cytochrome P450 in rat liver
    Authors:
    Władysława Anna Daniel, Anna Haduch, Ewa Bromek, Jacek Wójcikowski, Marta Rysz
    Conference:
    19th International Conference on Cytochrome P450. Biochemistry, Biophysics, and Biotechnology (rok: 2015, ), Wydawca: ICCP450 Tokyo 2015
    Data:
    konferencja 12-15.06.2015
    Status:
    Published
  2. The effect of serotonergic receptor activation in the paraventricular nuclei of the hypothalamus on the expression of liver cytochrome P450
    Authors:
    Ewa Bromek, Marta Rysz, Anna Haduch, Władysława A. Daniel
    Conference:
    29th European College of Neuropsychopharmacology Congress, Vienna, Austria (rok: 2016, ), Wydawca: Elsevier, Amsterdam, Holandia
    Data:
    konferencja 17-20 września, 2016
    Status:
    Published
    DOI:
    link to the publication
  3. Activation of 5-HT1A receptors in the hypothalamic paraventricular nuclei (PVN) negatively regulates cytochrome P450 expression in rat liver
    Authors:
    Anna Haduch, Ewa Bromek, Marta Rysz, Jacek Wójcikowski, Władysława A. Daniel
    Conference:
    13th World Congress of Biological Psychiatry (rok: 2017, ), Wydawca: World Federation of Societes of Biological Psychiatry
    Data:
    konferencja 18-22 czerwca, 2017
    Status:
    Published
  4. Opposite role of the serotonergic innervation of the hypothalamic paraventricular or arcuate nuclei in the central neuroendocrine regulation of liver cytochrome P450
    Authors:
    Marta Rysz, Ewa Bromek, Anna Haduch, Jacek Wójcikowski, Władysława A. Daniel
    Conference:
    29th European College of Neuropsychopharmacology Congress, Vienna, Austria (rok: 2016, ), Wydawca: Elsevier, Amsterdam, Holandia
    Data:
    konferencja 17-20 września, 2016
    Status:
    Published
    DOI:
    link to the publication
  5. The stimulating effect of 5-HT2 receptor activation in the hypothalamic arcuate nuclei (ARC) on cytochrome P450 activity in rat liver
    Authors:
    Marta Rysz, Ewa Bromek, Anna Haduch, Władysława A. Daniel
    Conference:
    13th World Congress of Biological Psychiatry (rok: 2017, ), Wydawca: World Federation of Societes of Biological Psychiatry
    Data:
    konferencja 18-22 czerwca, 2017
    Status:
    Published

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