Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Extramitochondrial factors regulating turnover of mitochondrial intermembrane space proteins

2013/11/D/NZ1/02294

Keywords:

mitochondria ubiquitin-proteasome system protein turnover

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ3_1: Cell biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Piotr Brągoszewski 

Number of co-investigators in the project: 2

Call: SONATA 6 - announced on 2013-09-16

Amount awarded: 796 100 PLN

Project start date (Y-m-d): 2014-07-24

Project end date (Y-m-d): 2017-12-23

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirnik wychylny z pojemnikami na wielopłytki (6 955 PLN)
  2. Komputer wraz z oprogramowaniem (10 000 PLN)
  3. Pipeta wielokanałowa elektroniczna z możliwością dozowania wielu porcji (2 szt.) (8 640 PLN)
  4. Termomikser wraz z blokami grzewczymi do wielopłytek i standardowych probówek 1,5ml (19 700 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (1)
  1. Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol
    Authors:
    Lidia Wrobel, Ulrike Topf, Piotr Bragoszewski, Sebastian Wiese, Malgorzata E. Sztolsztener, Silke Oeljeklaus, Aksana Varabyova, Maciej Lirski, Piotr Chroscicki, Seweryn Mroczek, Elzbieta Januszewicz, Andrzej Dziembowski, Marta Koblowska, Bettina Warscheid, Agnieszka Chacinska
    Academic press:
    Nature (rok: 2015, tom: 524, strony: 485–488), Wydawca: Nature Publishing Group / Macmillan Publishers Limited
    Status:
    Published
    DOI:
    10.1038/nature14951 - link to the publication
  2. Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system
    Authors:
    Piotr Bragoszewski, Michal Turek, Agnieszka Chacinska
    Academic press:
    Open Biology (rok: 2017, tom: 7: 170007, strony: 45304), Wydawca: The Royal Society
    Status:
    Published
    DOI:
    10.1098/rsob.170007 - link to the publication
  3. Retro-translocation of mitochondrial intermembrane space proteins
    Authors:
    Piotr Bragoszewski, Michal Wasilewski, Paulina Sakowska, Agnieszka Gornicka, Lena Böttinger, Jian Qiu, Nils Wiedemann, Agnieszka Chacinska
    Academic press:
    Proceedings of the National Academy of Sciences of the United States of America (rok: 2015, tom: vol. 112 no. 25, strony: 7713–7718), Wydawca: National Academy of Sciences of the United States of America
    Status:
    Published
    DOI:
    10.1073/pnas.1504615112 - link to the publication
  4. Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo‐tomography
    Authors:
    Vicki AM Gold, Piotr Chroscicki, Piotr Bragoszewski, Agnieszka Chacinska
    Academic press:
    EMBO reports (rok: 2017, tom: 18, strony: 1786-1800), Wydawca: EMBO Press
    Status:
    Published
    DOI:
    10.15252/embr.201744261 - link to the publication
  5. Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins
    Authors:
    Lukasz Kowalski, Piotr Bragoszewski, Anton Khmelinskii, Edyta Glow, Michael Knop, Agnieszka Chacinska
    Academic press:
    BMC Biology (rok: 2018, tom: 0,7125, strony: 45313), Wydawca: BIOMED CENTRAL LTD. A part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12915-018-0536-1 - link to the publication
  1. The ubiquitin-proteasome system mediated control of mitochondrial intermembrane space proteins
    Authors:
    Piotr Bragoszewski, Agnieszka Chacinska
    Conference:
    BIO 2016 Congress (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN ISSN 1734-154X
    Data:
    konferencja 13-16.09.2016
    Status:
    Published
    DOI:
    link to the publication

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