Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Nanoparticles of gold, gold-gold sulfide and titanium dioxide modified with tellurium as carriers for At-211 for targeted alpha therapy

2013/11/B/ST4/00516

Keywords:

astatine radionuclide therapy nanotechnology

Descriptors:

  • ST4_16: Ionic liquids
  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST4_2: Spectroscopic and spectrometric techniques

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Chemii i Techniki Jądrowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Aleksander Bilewicz 

Number of co-investigators in the project: 9

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 737 480 PLN

Project start date (Y-m-d): 2014-09-17

Project end date (Y-m-d): 2018-09-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Kolumny do chromatografii wykluczenia z wypełnieniem polimerowym (16 000 PLN)
  2. Mikroskop odwrócony.
  3. Kolumna PRP-1 z zestawem.
  4. Piec rurowy (25 000 PLN)
  5. Aparat do elektroforezy żelowej (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Silver impregnated nanoparticles of titanium dioxide as carriers for 211At
    Authors:
    Edyta Leszczuk, Monika Łyczko, Agata Piotrowska, Anna Stolarz, Agnieszka Trzcińska, Katarzyna Szkliniarz, Bogdan Wąs, Aleksander Bilewicz
    Academic press:
    Radiochimica Acta (rok: 2016, tom: 104, strony: 267-275), Wydawca: Walter de Gruyter
    Status:
    Published
    DOI:
    10.1515/ract-2014-2373 - link to the publication
  2. Gold nanoparticle bioconjugates labelled with 211At for targeted alpha therapy
    Authors:
    L.Dziawer, P.Koźmiński, S.Męczyńska-Wielgosa, M.Pruszyński, M.Łyczko, B.Wąs, G.Celichowski, J.Grobelny, J.Jastrzębski, A. Bilewicz
    Academic press:
    RSC Advance (rok: 2017, tom: 7, strony: 41024-41032), Wydawca: ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
    Status:
    Published
    DOI:
    10.1039/c7ra06376h - link to the publication
  3. On AunAt clusters as an potential astatine carriers
    Authors:
    Sławomir Ostrowski, Agnieszka Majkowska, Aleksander Bilewicz*, Jan Cz. Dobrowolski
    Academic press:
    RSC Advaces (rok: 2017, tom: 7, strony: 35854-35857), Wydawca: ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
    Status:
    Published
    DOI:
    10.1039/c7ra05224c - link to the publication
  4. Trastuzumab modified gold nanoparticles labeled with 211At for local treatment of HER2-positive breast cancer
    Authors:
    Ł.Dziawer, A. Majkowska-Pilip, M. Godlewska, D. Gaweł, M. Pruszyński, J. Jastrzębski, B. Wąs, A. Bilewicz
    Academic press:
    Nanomaterials (rok: 2019, tom: 9, strony: 632-647), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/nano9040632 - link to the publication
  5. 211At labeled substance P (5–11) as potential radiopharmaceutical for glioma treatment
    Authors:
    Monika Lyczko, Marek Pruszynski, Agnieszka Majkowska-Pilip, Krzysztof Lyczko, Bogdan Was, Sylwia Meczynska-Wielgosz, Marcin Kruszewski, Katarzyna Szkliniarz, Jerzy Jastrzebski, Anna Stolarz, Aleksander Bilewicz
    Academic press:
    Nuclear Medicine and Biology (rok: 2017, tom: 53, strony: 45299), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.nucmedbio.2017.05.008 - link to the publication

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