Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New modified bacteriochlorins in photoimmunotherapy. Chemical and biological aspects.

2013/11/D/ST5/02995

Keywords:

bacteriochlorins photoimmunotherapy reactive oxygen species nitric oxide molecular mechanisms

Descriptors:

  • ST5_16:
  • ST5_14: Other related subjects
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Janusz Dąbrowski 

Number of co-investigators in the project: 9

Call: SONATA 6 - announced on 2013-09-16

Amount awarded: 498 900 PLN

Project start date (Y-m-d): 2014-07-01

Project end date (Y-m-d): 2017-06-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. System MagPix (105 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  • Book publications / chapters in book publications (1)
  1. Bioinorganic antimicrobial strategies in the resistance era
    Authors:
    AnnaRegiel-Futyra, Janusz M. Dąbrowski, Olga Mazuryk, Klaudyna Śpiewak, Agnieszka Kyzioł, Małgorzata Brindell, Grażyna Stochel
    Academic press:
    Coordination Chemistry Reviews (rok: 2017, tom: 351, strony: 76–117), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2017.05.005 - link to the publication
  2. Synthesis and biological distribution study of a new carbon-11 labeled porphyrin for PET imaging. Photochemical and biological characterization of the non-labeled porphyrin
    Authors:
    Nuno P. F. Gonçalves, Ana V. C. Simões, Artur R. Abreu, Antero J. Abrunhosa, Janusz M. Dąbrowski, Mariette M. Pereira
    Academic press:
    Journal of Porphyrins and Phthalocyanines (rok: 2015, tom: 19, strony: 946–955), Wydawca: World Scientific Publishing Company
    Status:
    Published
    DOI:
    10.1142/S1088424615500728 - link to the publication
  3. Design of Pluoronic-Based Formulation for Enhanced Redaporfin-Photodynamic Therapy against Pigmented Melanoma
    Authors:
    Barbara Pucelik, Luis G. Arnaut, Grażyna Stochel and Janusz M. Dąbrowski
    Academic press:
    ACS Appl. Mater. Interfaces (rok: 2016, tom: 8, strony: 22039−22055), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsami.6b07031 - link to the publication
  4. Elimination of primary tumours and control of metastasis with rationally designed bacteriochlorin photodynamic therapy regimens
    Authors:
    Luis B. Rocha, Ligia C. Gomes-da-Silva, Janusz M. Dabrowski, Luis G. Arnaut
    Academic press:
    European Journal of Cancer (rok: 2015, tom: 51, strony: 1822– 1830), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejca.2015.06.002 - link to the publication
  5. Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers
    Authors:
    J.M. Dąbrowski, B. Pucelik, A. Regiel-Futyra, M. Brindell, O. Mazuryk, A. Kyzioł, G. Stochel, W. Macyk, L.G. Arnaut
    Academic press:
    Coord. Chem. Rev. (rok: 2016, tom: 325, strony: 67-101), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2016.06.007 - link to the publication
  6. Intravenous Single-Dose Toxicity of Redaporfin-Based Photodynamic Therapy in Rodents
    Authors:
    Luis B. Rocha, Fábio Schaberle, Janusz M. Da˛browski, Sérgio Simões, Luis G. Arnaut
    Academic press:
    International Journal of Molecular Sciences (rok: 2015, tom: 16, strony: 29236–29249), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms161226162 - link to the publication
  7. Pro-oxidant and Antioxidant Effects in Photodynamic Therapy: Cells Recognise that Not All Exogenous ROS Are Alike
    Authors:
    Helder T. Soares, Joana R. S. Campos, Ligia C. Gomes-da-Silva, Fabio A. Schaberle, Janusz M. Dabrowski, Luis G. Arnaut
    Academic press:
    ChemBioChem (rok: 2016, tom: 17, strony: 836-842), Wydawca: Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim
    Status:
    Published
    DOI:
    0.1002/cbic.201500573 - link to the publication
  8. Towards tuning PDT relevant photosensitizer properties: comparative study for the free and Zn2+ coordinated meso-tetrakis[2,6-difluoro-5-(Nmethylsulfamylo) phenyl]porphyrin
    Authors:
    Janusz M. Dąbrowski, Barbara Pucelik, Mariette M. Pereira, Luis G. Arnaut, Grażyna Stochel
    Academic press:
    Journal of Coordination Chemistry (rok: 2015, tom: 68, strony: 3116–3134), Wydawca: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/00958972.2015.1073723 - link to the publication
  9. Mechanistic studies on versatile metal-assisted hydrogen peroxide activation processes for biomedical and environmental incentives
    Authors:
    M. Oszajca, M. Brindell, Ł. Orzeł, J. M. Dąbrowski, K. Śpiewak, P. Łabuz, M. Pacia, A. Stochel-Gaudyn, W. Macyk, R. van Eldik, G. Stochel
    Academic press:
    Coord. Chem. Rev. (rok: 2016, tom: 327-328, strony: 143-165), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2016.05.013 - link to the publication
  10. Photodynamic therapy (PDT) of cancer: from local to systemic treatment
    Authors:
    Janusz M. Dąbrowski, Luis G. Arnaut
    Academic press:
    Photochemical & Photobiological Sciences (rok: 2015, tom: 14, strony: 1765–1780), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5pp00132c - link to the publication
  11. Translating phototherapeutic indices from in vitro to in vivo photodynamic therapy with bacteriochlorins
    Authors:
    André FS Luz, Barbara Pucelik, Mariette M Pereira, Janusz M Dąbrowski, Luis G Arnaut
    Academic press:
    Lasers in surgery and medicine (rok: 2018, tom: 50, strony: 451-459), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/lsm.22931 - link to the publication
  1. Reactive Oxygen Species in Photodynamic Therapy: Mechanisms of Their Generation and Potentiation
    Authors:
    Janusz M. Dąbrowski
    Book:
    Advances in Inorganic Chemistry (rok: 2017, tom: 70, strony: 343-394), Wydawca: Elsevier
    Status:
    Published

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