Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Protein stability in aqueous solutions of osmolytes studied through complementary theoretical and experimental approach

2013/11/B/NZ1/02258

Keywords:

Osmophobic effect osmolytes proteins aqueous solutions IR spectroscopy molecular dynamics ab initio calculations calorimetry

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry
  • NZ2_8: Computational biology
  • NZ1_3: Biophysics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Stangret 

Number of co-investigators in the project: 6

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 685 940 PLN

Project start date (Y-m-d): 2014-07-10

Project end date (Y-m-d): 2017-07-09

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Stacja robocza o dużej mocy obliczeniowej (15 000 PLN)
  2. Stacje robocze PC (16 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Molecular basis of the osmolyte effect on protein stability: a lesson from the mechanical unfolding of lysozyme
    Authors:
    Beata Adamczak, Miłosz Wieczór, Mateusz Kogut, Janusz Stangret, Jacek Czub
    Academic press:
    Biochemical Journal (rok: 2016, tom: 473, strony: 3705-3724), Wydawca: Portland Press Ltd
    Status:
    Published
    DOI:
    10.1042/BCJ20160604 - link to the publication
  2. Taurine as a water structure breaker and protein stabilizer
    Authors:
    P. Bruździak, A. Panuszko, E. Kaczkowska, B. Piotrowski, A. Daghir, S. Demkowicz, J. Stangret
    Academic press:
    Amino Acids (rok: 2018, tom: 50, strony: 125-140), Wydawca: Springer Wien
    Status:
    Published
    DOI:
    10.1007/s00726-017-2499-x - link to the publication
  3. General Mechanism of Osmolytes' Influence on Protein Stability Irrespective of the Type of Osmolyte Cosolvent
    Authors:
    Aneta Panuszko, Piotr Bruździak, Emilia Kaczkowska, Janusz Stangret
    Academic press:
    Journal of Physical Chemistry B (rok: 2016, tom: 120, strony: 11159-11169), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.6b10119 - link to the publication
  4. Are stabilizing osmolytes preferentially excluded from the protein surface? FTIR and MD studies
    Authors:
    P. Bruździak, B. Adamczak, E. Kaczkowska, J. Czub, J. Stangret
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2015, tom: 17, strony: 23155-23164), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C5CP03065J - link to the publication
  5. Structural changes of a simple peptide—Trpzip-1—in aqueous solutions and the corresponding hydration phenomena under the influence of temperature
    Authors:
    P. Bruździak, A. Panuszko, B. Piotrowski, J. Stangret
    Academic press:
    Journal of Molecular Liquids (rok: 2019, tom: 277, strony: 532-540), Wydawca: Elsevier Science B.V.
    Status:
    Published
    DOI:
    10.1016/j.molliq.2018.12.101 - link to the publication
  6. Effect of osmolytes on the thermal stability of proteins: replica exchange simulations of Trp-cage in urea and betaine solutions
    Authors:
    B. Adamczak, M. Kogut, J. Czub
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2018, tom: 20, strony: 11174-11182), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7cp07436k - link to the publication
  7. Protein thermal stabilization in aqueous solutions of osmolytes
    Authors:
    P. Bruździak, A. Panuszko, M. Jourdan, J. Stangret
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: 65-70), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/abp.2014_950 - link to the publication
  8. Hydration of amino acids: FTIR spectra and molecular dynamics studies
    Authors:
    A. Panuszko, B. Adamczak, J. Czub, E. Gojło, J. Stangret
    Academic press:
    Amino Acids (rok: 2015, tom: 47, strony: 2265-2278), Wydawca: Springer Wien
    Status:
    Published
    DOI:
    10.1007/s00726-015-2005-2 - link to the publication

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