Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Protein stability in aqueous solutions of osmolytes studied through complementary theoretical and experimental approach

2013/11/B/NZ1/02258

Keywords:

Osmophobic effect osmolytes proteins aqueous solutions IR spectroscopy molecular dynamics ab initio calculations calorimetry

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry
  • NZ2_8: Computational biology
  • NZ1_3: Biophysics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Stangret 

Number of co-investigators in the project: 6

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 685 940 PLN

Project start date (Y-m-d): 2014-07-10

Project end date (Y-m-d): 2017-07-09

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Stacja robocza o dużej mocy obliczeniowej (15 000 PLN)
  2. Stacje robocze PC (16 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Hydration of amino acids: FTIR spectra and molecular dynamics studies
    Authors:
    A. Panuszko, B. Adamczak, J. Czub, E. Gojło, J. Stangret
    Academic press:
    Amino Acids (rok: 2015, tom: 47, strony: 2265-2278), Wydawca: Springer Wien
    Status:
    Published
    DOI:
    10.1007/s00726-015-2005-2 - link to the publication
  2. Protein thermal stabilization in aqueous solutions of osmolytes
    Authors:
    P. Bruździak, A. Panuszko, M. Jourdan, J. Stangret
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: 65-70), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/abp.2014_950 - link to the publication
  3. Taurine as a water structure breaker and protein stabilizer
    Authors:
    P. Bruździak, A. Panuszko, E. Kaczkowska, B. Piotrowski, A. Daghir, S. Demkowicz, J. Stangret
    Academic press:
    Amino Acids (rok: 2018, tom: 50, strony: 125-140), Wydawca: Springer Wien
    Status:
    Published
    DOI:
    10.1007/s00726-017-2499-x - link to the publication
  4. Are stabilizing osmolytes preferentially excluded from the protein surface? FTIR and MD studies
    Authors:
    P. Bruździak, B. Adamczak, E. Kaczkowska, J. Czub, J. Stangret
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2015, tom: 17, strony: 23155-23164), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C5CP03065J - link to the publication
  5. Effect of osmolytes on the thermal stability of proteins: replica exchange simulations of Trp-cage in urea and betaine solutions
    Authors:
    B. Adamczak, M. Kogut, J. Czub
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2018, tom: 20, strony: 11174-11182), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7cp07436k - link to the publication
  6. General Mechanism of Osmolytes' Influence on Protein Stability Irrespective of the Type of Osmolyte Cosolvent
    Authors:
    Aneta Panuszko, Piotr Bruździak, Emilia Kaczkowska, Janusz Stangret
    Academic press:
    Journal of Physical Chemistry B (rok: 2016, tom: 120, strony: 11159-11169), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.6b10119 - link to the publication
  7. Molecular basis of the osmolyte effect on protein stability: a lesson from the mechanical unfolding of lysozyme
    Authors:
    Beata Adamczak, Miłosz Wieczór, Mateusz Kogut, Janusz Stangret, Jacek Czub
    Academic press:
    Biochemical Journal (rok: 2016, tom: 473, strony: 3705-3724), Wydawca: Portland Press Ltd
    Status:
    Published
    DOI:
    10.1042/BCJ20160604 - link to the publication
  8. Structural changes of a simple peptide—Trpzip-1—in aqueous solutions and the corresponding hydration phenomena under the influence of temperature
    Authors:
    P. Bruździak, A. Panuszko, B. Piotrowski, J. Stangret
    Academic press:
    Journal of Molecular Liquids (rok: 2019, tom: 277, strony: 532-540), Wydawca: Elsevier Science B.V.
    Status:
    Published
    DOI:
    10.1016/j.molliq.2018.12.101 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy