Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Investigation of the role of heat shock protein hsp70 in the mechanisms of microRNA generation and functioning, regulating inflammatory processes in the course of autoimmune demyelination.

2013/11/B/NZ6/02055

Keywords:

heat shock protein hsp70 microRNA multiple sclerosis autoimmune demyelination

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ1_1: Molecular biology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Hanna Ćwiklińska 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 681 960 PLN

Project start date (Y-m-d): 2014-07-25

Project end date (Y-m-d): 2017-12-24

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. System do elektroforezy i transferu białek oraz do analizy otrzymanych wyników. (50 000 PLN)
  2. Zestaw do ilościowego oznaczania transkryptów QX200 (digital PCR), współfinansowanie.
  3. Aparat do fragmentacji DNA/RNA do Wysokoprzepustowego Sekwencjonowania DNA (100 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Induction of human IL-10-producing neutrophils by LPS-stimulated Treg cells and IL-10.
    Authors:
    Lewkowicz N, Mycko MP, Przygodzka P, Ćwiklińska H, Cichalewska M, Matysiak M, Selmaj K, Lewkowicz P.
    Academic press:
    Mucosal Immunology (rok: 2015, tom: 42214, strony: 15), Wydawca: Nature publishing Group
    Status:
    Published
    DOI:
    10.1038/mi.2015.66 - link to the publication
  2. Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.
    Authors:
    Przemysław Lewkowicz, Hanna Cwiklinska, Marcin P. Mycko, Maria Cichalewska, Małgorzata Domowicz, Natalia Lewkowicz, Anna Jurewicz, and Krzysztof W. Selmaj
    Academic press:
    The Journal of Neuroscience (rok: 2015, tom: 35(19), strony: 7521–7537), Wydawca: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.4794-14.2015. - link to the publication
  3. miR-155-3p Drives the Development of Autoimmune Demyelination by Regulation of Heat Shock Protein 40.
    Authors:
    Mycko MP, Cichalewska M, Cwiklinska H, Selmaj KW
    Academic press:
    The Journal of Neuroscience (rok: 2015, tom: 35(50), strony: 16504-15.), Wydawca: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.2830-15. - link to the publication
  4. Heat shock protein 70 (Hsp70) interacts with the Notch1 intracellular domain and contributes to the activity of Notch signaling in myelin-reactive CD4 T cells
    Authors:
    Maciej Juryńczyk, Przemysław Lewkowicz, Małgorzata Domowicz, Marcin P. Mycko, KrzysztofW. Selmaj
    Academic press:
    Journal of Neuroimmunology (rok: 2015, tom: 287, strony: 19–26), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2015.08.007. - link to the publication
  5. The Heat Shock Protein HSP70 Promotes Th17 Genes' Expression via Specific Regulation of microRNA
    Authors:
    Hanna Cwiklinska, Maria Cichalewska-Studzinska, Krzysztof W Selmaj, Marcin P Mycko
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 2823), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21082823 - link to the publication

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