Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Investigation of the role of heat shock protein hsp70 in the mechanisms of microRNA generation and functioning, regulating inflammatory processes in the course of autoimmune demyelination.

2013/11/B/NZ6/02055

Keywords:

heat shock protein hsp70 microRNA multiple sclerosis autoimmune demyelination

Descriptors:

  • NZ6_1:
  • NZ1_1:
  • NZ5_3:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Hanna Ćwiklińska 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 681 960 PLN

Project start date (Y-m-d): 2014-07-25

Project end date (Y-m-d): 2017-12-24

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. System do elektroforezy i transferu białek oraz do analizy otrzymanych wyników. (50 000 PLN)
  2. Zestaw do ilościowego oznaczania transkryptów QX200 (digital PCR), współfinansowanie.
  3. Aparat do fragmentacji DNA/RNA do Wysokoprzepustowego Sekwencjonowania DNA (100 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. The Heat Shock Protein HSP70 Promotes Th17 Genes' Expression via Specific Regulation of microRNA
    Authors:
    Hanna Cwiklinska, Maria Cichalewska-Studzinska, Krzysztof W Selmaj, Marcin P Mycko
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 2823), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21082823 - link to the publication
  2. Induction of human IL-10-producing neutrophils by LPS-stimulated Treg cells and IL-10.
    Authors:
    Lewkowicz N, Mycko MP, Przygodzka P, Ćwiklińska H, Cichalewska M, Matysiak M, Selmaj K, Lewkowicz P.
    Academic press:
    Mucosal Immunology (rok: 2015, tom: 42214, strony: 15), Wydawca: Nature publishing Group
    Status:
    Published
    DOI:
    10.1038/mi.2015.66 - link to the publication

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