Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Studies on the anticonvulsant activity of 4-alkyl-5-aryl-1,2,4-triazole-3-thione derivatives

2013/11/D/NZ7/01170

Keywords:

s-triazole derivatives anticonvulsant activity MES seizure test s.c.PTZ seizure test drug-resistant epilepsy pharmacokinetic studies HPLC studies

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Plech 

Number of co-investigators in the project: 4

Call: SONATA 6 - announced on 2013-09-16

Amount awarded: 597 850 PLN

Project start date (Y-m-d): 2014-08-13

Project end date (Y-m-d): 2018-10-12

Project duration:: 50 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Kamera do mikroskopu fluorescencyjnego wraz z oprogramowaniem, łącznikiem i zestawem komputerowym (49 002 PLN)
  2. Zestaw do elektroforezy horyzontalnej.
  3. Aparat rota-rod (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Molecular mechanism of action and safety of 5-(3- chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3- thione – a novel anticonvulsant drug candidate
    Authors:
    Barbara Kaproń, Jarogniew Łuszczki, Agata Paneth, Monika Wujec, Agata Siwek, Tadeusz Karcz, Barbara Mordyl, Monika Głuch-Lutwin, Anna Gryboś, Gabriel Nowak, Karolina Pająk, Krzysztof Jóźwiak, Adam Tomczykowski, Tomasz Plech
    Academic press:
    International Journal of Medical Sciences (rok: 2017, tom: 14, strony: 741-749), Wydawca: IVYSPRING INTERNATIONAL PUBLISHER
    Status:
    Published
    DOI:
    10.7150/ijms.20001 - link to the publication
  2. New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model.
    Authors:
    Jarogniew Luszczki, Paweł Marzęda, Agata Gut-Lepiech, Maria Kondrat-Wróbel, Paula Wróblewska-Łuczka, Sławomir Karwan, Tomasz Plech
    Academic press:
    Pharmacological Reports (rok: 2019, tom: 71, strony: 299-305), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2019.01.003 - link to the publication
  3. Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3- thiones and their effect on GABAergic system
    Authors:
    Tomasz Plech, Barbara Kaproń, Jarogniew J. Łuszczki, Agata Paneth, Agata Siwek, Marcin Kołaczkowski, Maria Żołnierek, Gabriel Nowak
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2014, tom: 86, strony: 690-699), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2014.09.034 - link to the publication
  4. Comparison of mouse plasma and brain tissue homogenate sample pretreatment methods prior to high-performance liquid chromatography for a new 1,2,4-triazole derivative with anticonvulsant activity
    Authors:
    Jolanta Flieger, Anna Kowalska, Magdalena Pizoń, Tomasz Plech, Jarogniew Łuszczki
    Academic press:
    Journal of Separation Science (rok: 2015, tom: 38, strony: 2149–2157), Wydawca: WILEY-VCH Verlag GmbH & Co
    Status:
    Published
    DOI:
    10.1002/jssc.201500221 - link to the publication
  5. Studies on the AnticonvulsantActivity and influence on GABA-ergic neurotransmission of 1,2,4-triazole-3-thione-based compounds
    Authors:
    Tomasz Plech, Barbara Kaproń, Jarogniew J. Łuszczki, Monika Wujec, Agata Paneth, Agata Siwek, Marcin Kołaczkowski, Maria Żołnierek, Gabriel Nowak
    Academic press:
    Molecules (rok: 2014, tom: 19, strony: 11279-11299), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules190811279 - link to the publication
  6. Anticonvulsant and neurotoxic effects of a novel 1,2,4-triazole-3-thione derivative (TPF-34) and its isobolographic interaction profile with classical antiepileptic drugs in mice
    Authors:
    Jarogniew Luszczki, Jacek Lepiech, Mirosław Zagaja, Paula Wróblewska-Łuczka, Magdalena Florek-Łuszczki, Hubert Bojar, Aleksandra Walczak, Tomasz Plech
    Academic press:
    Pharmacological Reports (rok: 2019, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  7. Multi-targeted anticonvulsant agents exerting additional ROS scavenging activity are effective in a pharmacoresistant model of epilepsy
    Authors:
    Barbara Kaproń, Tomasz Plech
    Academic press:
    Biomolecules (rok: 2019, tom: brak, strony: brak), Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication
  8. Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from invivo, in-vitro, and in-silico studies.
    Authors:
    Barbara Kaproń, Jarogniew Łuszczki, Anita Płazińska, Agata Siwek, Tadeusz Karcz, Anna Gryboś, Gabriel Nowak, Anna Makuch-Kocka, Katarzyna Walczak, Ewa Langner, Karolina Szalast, Sebastian Marciniak, Magdalena Paczkowska, Judyta Cielecka-Piontek, Lukasz Ciesla, Tomasz Plech
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2019, tom: 129, strony: 42-57), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2018.12.018 - link to the publication
  9. High-performance liquid chromatography thermodynamic study of new potential antiepileptic compounds on a cholesterol column using isocratic elution with methanol/water and acetonitrile/water eluent systems
    Authors:
    Jolanta Flieger, Hanna Trębacz, Magdalena Pizoń, Anna Kowalska, Agnieszka Szczęsna, Tomasz Plech
    Academic press:
    Journal of Separation Science (rok: 2018, tom: 40, strony: 4176-4190), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/jssc.201700748 - link to the publication
  10. Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltagegated sodium channels (VGSCs) as promising anticonvulsant drug candidates
    Authors:
    Barbara Kaproń, Jarogniew J. Łuszczki, Agata Siwek, Tadeusz Karcz, Gabriel Nowak, Mirosław Zagaja, Marta Andres-Mach, Anna Stasiłowicz, Judyta Cielecka-Piontek, Janusz Kocki, Tomasz Plech
    Academic press:
    Bioorganic Chemistry (rok: 2019, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.bioorg.2019.103355 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy