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Application of modified DNAzymes with peroxidase-mimicking activity in biomedical diagnostics

2013/10/M/ST4/00490

Keywords:

DNAzyme peroxidase SPR LSPR

Descriptors:

  • NZ5_5: Diagnostics in human diseases
  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST5_12: Methods of nanomaterials/materials synthesis

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bernard Juskowiak 

Number of co-investigators in the project: 10

Call: HARMONIA 5 - announced on 2013-06-14

Amount awarded: 1 000 220 PLN

Project start date (Y-m-d): 2014-05-06

Project end date (Y-m-d): 2018-05-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (6)
  1. Increasing the activity of DNAzyme based on the telomeric sequence: 2'-OMe-RNA and LNA modifications
    Authors:
    Joanna Kosman, Krzysztof Żukowski, Bernard Juskowiak
    Academic press:
    Open Chemistry , Wydawca: De Gruyter
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  2. Conjugation of Hemin to G-quadruplex Forming Oligonucleotide Using Click Chemistry
    Authors:
    Joanna Kosman, Alicja Stanislawska, Agata Gluszynska, Bernard Juskowiak
    Academic press:
    International Journal of Biological Macromolecules (rok: 2017, tom: 101, strony: 799-804), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2017.03.170 - link to the publication
  3. Hemin/G-quadruplex structure and activity alteration induced by magnesium cations
    Authors:
    Joanna Kosman, Bernard Juskowiak
    Academic press:
    International Journal of Biological Macromolecules (rok: 2016, tom: 85, strony: 555-564), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2016.01.020 - link to the publication
  4. Dataset on characterization of hemin-azide derivative and DNA oligonucleotide-hemin conjugate
    Authors:
    Kosman Joanna, Stanisławska Alicja, Głuszyńska Agata, Juskowiak Bernard
    Academic press:
    Data in Brief (rok: 2017, tom: 13, strony: 1-2653-59), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dib.2017.05.020 - link to the publication
  5. Comparison of Characteristics and DNAzyme Activity of G4–Hemin Conjugates Obtained via Two Hemin Attachment Methods
    Authors:
    Joanna Kosman,Krzysztof Żukowski, Bernard Juskowiak
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: 1400), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23061400 - link to the publication
  6. New strategy for silver deposition on Au nanoparticles with the use of peroxidase-mimicking DNAzyme monitored by Localized Surface Plasmon Resonance technique
    Authors:
    Joanna Kosman, Jacqueline Jatschka, Andrea Csaki, Wolfgang Fritzsche, Bernard Juskowiak, Ondrej Stranik
    Academic press:
    Sensors (rok: 2017, tom: 17, strony: 849), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/s17040849 - link to the publication
  1. Peroxidase-mimicking DNAzyme based on DNA oligonucleotides with point LNA modification
    Authors:
    J. Kosman, A. Nawrocka, K. Żukowski, B. Juskowiak
    Conference:
    44thd International Conference of SSCHE (rok: 2017, ), Wydawca: Slovak Society of Chemical Engineering
    Data:
    konferencja Maj 22–26
    Status:
    Published
    DOI:
    link to the publication
  2. "Click" synthesis of hemin-oligonucleotide DNAzyme for peroxidase activity
    Authors:
    Joanna Kosman, Alicja Stanislawska, Bernard Juskowiak
    Conference:
    43rd International Conference of SSCHE (rok: 2016, ), Wydawca: Slovak Society of Chemical Engineering
    Data:
    konferencja 23–27, 05 2016
    Status:
    Published
    DOI:
    link to the publication
  3. 2'-OMe-RNA analogues of peroxidase-mimicking DNAzymes
    Authors:
    Joanna Kosman, Bernard Juskowiak
    Conference:
    30th Eurosensors Conference, EUROSENSORS 2016 (rok: 2016, ), Wydawca: Procedia Engineering (Elsevier)
    Data:
    konferencja 4-7 09 2016
    Status:
    Published
    DOI:
    link to the publication
  4. "Oligonukleotydowe układy z kowalencyjnie przyłączoną heminą jako DNAzymy o aktywności peroksydazowej
    Authors:
    Żukowski K., Kosman J., Juskowiak B.,
    Conference:
    " Nauka i przemysł – metody spektroskopowe w praktyce, nowe wyzwania i możliwości6 (rok: 2016, ), Wydawca: UMCS
    Data:
    konferencja 06 06 2016
    Status:
    Published
    DOI:
    link to the publication
  5. Characterization of peroxidase-mimicking dnazyme synthesised by conjugation of DNA oligonucleotide with hemin-nhs ester
    Authors:
    Krzysztof Zukowski, Joanna Kosman, Bernard Juskowiak
    Conference:
    43rd International Conference of the SSCE (rok: 2016, ), Wydawca: Slovak Society of Chemical Engineering
    Data:
    konferencja 23-27, 05 2016
    Status:
    Published
    DOI:
    link to the publication
  6. Modified dnazyme based on catg4 sequence: dna-hemin and dna-qd conjugates
    Authors:
    K. Żukowski, J. Kosman,, B. Juskowiak
    Conference:
    44thd International Conference of SSCHE (rok: 2017, ), Wydawca: Slovak Society of Chemical Engineering
    Data:
    konferencja Maj 22–26
    Status:
    Published

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