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Application of modified DNAzymes with peroxidase-mimicking activity in biomedical diagnostics

2013/10/M/ST4/00490

Keywords

Descriptors

  • NZ5_5: Diagnostyka chorób człowieka
  • ST4_13: Chemia fizyczna układów biologicznych
  • ST5_12: Materiały "inteligentne" – materiały samoorganizujące się, materiały reagujące na bodźce zewnętrzne

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Bernard Juskowiak

Number of co-investigators in the project: 10

Call

HARMONIA 5 – announced on 2013-06-14

Amount awarded
1 000 220 PLN
Project start date
2014-05-06
Project end date
2018-05-05
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (6)

  1. Dataset on characterization of hemin-azide derivative and DNA oligonucleotide-hemin conjugate

    Authors:
    Kosman Joanna, Stanisławska Alicja, Głuszyńska Agata, Juskowiak Bernard
    Academic press:
    Data in Brief (year: 2017, volume: 13, pages: 1-2653-59), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dib.2017.05.020 – link to the publication

  2. Comparison of Characteristics and DNAzyme Activity of G4–Hemin Conjugates Obtained via Two Hemin Attachment Methods

    Authors:
    Joanna Kosman,Krzysztof Żukowski, Bernard Juskowiak
    Academic press:
    Molecules (year: 2018, volume: 23, pages: 1400), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23061400 – link to the publication

  3. Hemin/G-quadruplex structure and activity alteration induced by magnesium cations

    Authors:
    Joanna Kosman, Bernard Juskowiak
    Academic press:
    International Journal of Biological Macromolecules (year: 2016, volume: 85, pages: 555-564), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2016.01.020 – link to the publication

  4. New strategy for silver deposition on Au nanoparticles with the use of peroxidase-mimicking DNAzyme monitored by Localized Surface Plasmon Resonance technique

    Authors:
    Joanna Kosman, Jacqueline Jatschka, Andrea Csaki, Wolfgang Fritzsche, Bernard Juskowiak, Ondrej Stranik
    Academic press:
    Sensors (year: 2017, volume: 17, pages: 849), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/s17040849 – link to the publication

  5. Conjugation of Hemin to G-quadruplex Forming Oligonucleotide Using Click Chemistry

    Authors:
    Joanna Kosman, Alicja Stanislawska, Agata Gluszynska, Bernard Juskowiak
    Academic press:
    International Journal of Biological Macromolecules (year: 2017, volume: 101, pages: 799-804), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2017.03.170 – link to the publication

  6. Increasing the activity of DNAzyme based on the telomeric sequence: 2'-OMe-RNA and LNA modifications

    Authors:
    Joanna Kosman, Krzysztof Żukowski, Bernard Juskowiak
    Status:
    Accepted for publication

Articles in post-conference publications (6)

  1. Oligonukleotydowe układy z kowalencyjnie przyłączoną heminą jako DNAzymy o aktywności peroksydazowej

    Authors:
    Żukowski K., Kosman J., Juskowiak B.,
    Conference:
    Nauka i przemysł – metody spektroskopowe w praktyce, nowe wyzwania i możliwości6 (year: 2016, pages: 367-370.), Publisher: UMCS
    Date:
    conference 06 06 2016
    Status:
    Published

  2. Peroxidase-mimicking DNAzyme based on DNA oligonucleotides with point LNA modification

    Authors:
    J. Kosman, A. Nawrocka, K. Żukowski, B. Juskowiak
    Conference:
    44thd International Conference of SSCHE (year: 2017, pages: 213-218), Publisher: Slovak Society of Chemical Engineering
    Date:
    conference Maj 22–26
    Status:
    Published

  3. Modified dnazyme based on catg4 sequence: dna-hemin and dna-qd conjugates

    Authors:
    K. Żukowski, J. Kosman,, B. Juskowiak
    Conference:
    44thd International Conference of SSCHE (year: 2017, pages: 86-94), Publisher: Slovak Society of Chemical Engineering
    Date:
    conference Maj 22–26
    Status:
    Published

  4. Characterization of peroxidase-mimicking dnazyme synthesised by conjugation of DNA oligonucleotide with hemin-nhs ester

    Authors:
    Krzysztof Zukowski, Joanna Kosman, Bernard Juskowiak
    Conference:
    43rd International Conference of the SSCE (year: 2016, pages: 94–101), Publisher: Slovak Society of Chemical Engineering
    Date:
    conference 23-27, 05 2016
    Status:
    Published

  5. 2'-OMe-RNA analogues of peroxidase-mimicking DNAzymes

    Authors:
    Joanna Kosman, Bernard Juskowiak
    Conference:
    30th Eurosensors Conference, EUROSENSORS 2016 (year: 2016, pages: vol168, pp626-629), Publisher: Procedia Engineering (Elsevier)
    Date:
    conference 4-7 09 2016
    Status:
    Published
    DOI:
    link to the publication

  6. Click synthesis of hemin-oligonucleotide DNAzyme for peroxidase activity

    Authors:
    Joanna Kosman, Alicja Stanislawska, Bernard Juskowiak
    Conference:
    43rd International Conference of SSCHE (year: 2016, pages: 849–855), Publisher: Slovak Society of Chemical Engineering
    Date:
    conference 23–27, 05 2016
    Status:
    Published

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