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Building bacterial orisome on bipartite origins - structural, functional and regulatory aspects of the process based on the analysis of initiation of Helicobacter pylori chromosome replication.

2013/10/E/NZ1/00718

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • NZ1_4: Biologia strukturalna
  • NZ1_10: Biologia drobnoustrojów

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Anna Magdalena Pawlik

Number of co-investigators in the project: 7

Call

SONATA BIS 3 – announced on 2013-06-14

Amount awarded
1 500 000 PLN
Project start date
2014-06-10
Project end date
2020-12-09
Project duration
78 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. ACU Athmospheric Control Unit.
  2. Wirówka stołowa z rotorem 24x1,5/2ml.
  3. aparat do transferu biomolekuł. Cost: 8 220 PLN
  4. inkubator z możliwością wytrząsania. Cost: 74 000 PLN
  5. komora laminarna klasy II. Cost: 40 000 PLN
  6. komputer osobisty typu laptop (2 pcs). Cost: 7 000 PLN
  7. komputery ososbiste typu laptop (2 pcs). Cost: 6 000 PLN
  8. wirówka nastołowa z rotorem wychylnym. Cost: 35 000 PLN

Information in the final report

Publication in academic press/journals (7)

  1. Streptomycete origin of chromosomal replication with two putative unwinding elements

    Authors:
    Małgorzata Płachetka, Dorota Żyła-Uklejewicz, Christoph Weigel, Rafał Donczew, Magdalena Donczew, Dagmara Jakimowicz, Anna Zawilak-Pawlik, Jolanta Zakrzewska-Czerwinska
    Academic press:
    Microbiology (year: 2019, volume: 165, pages: 1365-1375), Publisher: Microbiology Society
    Status:
    Published
    DOI:
    10.1099/mic.0.000859 – link to the publication

  2. Unique and universal features of Epsilonproteobacterial origins of chromosome replication and DnaA-DnaA box interactions.

    Authors:
    Jaworski P., Donczew R., Mielke T., Thiel M., Oldziej S., Weigel C., Zawilak-Pawlik A
    Academic press:
    Frontiers in Microbiology (year: 2016, volume: 1,37152777777778, pages: 46036), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2016.01555 – link to the publication

  3. Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations

    Authors:
    V.Anna Zawilak-Pawlik, Urszula Zarzecka, Dorota Żyła-Uklejewicz, Jakub Lach, Dominik Strapagiel, Nicole Tegtmeyer, Manja Böhm, Steffen Backert, Joanna Skorko-Glonek
    Academic press:
    Scientific Reports (year: 2019, volume: 9, pages: 11794), Publisher: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-48030-6 – link to the publication

  4. The role of the N-terminal domain of bacterial initiator DnaA in the assembly and regulation of the bacterial replication initiation complex

    Authors:
    Zawilak-Pawlik A, Nowaczyk M, Zakrzewska-Czerwinska J
    Academic press:
    Genes (Basel) (year: 2017, volume: 8, pages: 46040), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/genes8050136 – link to the publication

  5. HP1021 is a redox switch protein identified in Helicobacter pylori.

    Authors:
    Szczepanowski, P.; Noszka, M.; Zdot;yła-Uklejewicz, D.; Pikuła, F.; Nowaczyk-Cieszewska, M.; Krȩżel, A.; Stingl, K.; Zawilak-Pawlik, A
    Academic press:
    Nucleic Acids Research (year: 2021, volume: 49, pages: 6863-6879), Publisher: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkab440 – link to the publication

  6. The role of Helicobacter pylori DnaA domain I in orisome assembly on a bipartite origin of chromosome replication

    Authors:
    Małgorzata Nowaczyk-Cieszewska, Dorota Żyła-Uklejewicz, Mateusz Noszka, Paweł Jaworski, Thorsten Mielke, Anna Zawilak-Pawlik.
    Academic press:
    Molecular Microbiology (year: 2020, volume: 113, pages: 338–355), Publisher: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/mmi.14423 – link to the publication

  7. Putative Cooperative ATP-DnaA Binding to Double-Stranded DnaA Box and Single-Stranded DnaA-Trio Motif upon Helicobacter pylori Replication Initiation Complex Assembly.

    Authors:
    Jaworski P, Zyla-Uklejewicz D, Nowaczyk-Cieszewska M, Donczew R, Mielke T, Weigel C, Zawilak-Pawlik A.
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 6643), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126643 – link to the publication

Book publications / chapters in book publications (1)

  1. Recent advances in Helicobacter pylori replication: possible implications in adaptation to a pathogenic lifestyle and perspectives for drug design.

    Authors:
    Zawilak-Pawlik A., Zakrzewska-Czerwińska J
    Book:
    Molecular Pathogenesis and Signal Transduction by Helicobacter pylori w serii Current Topics in Microbiology and Immunology (year: 2017, volume: 400, pages: 73-103), Publisher: Springer
    Status:
    Published

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