Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Building bacterial orisome on bipartite origins - structural, functional and regulatory aspects of the process based on the analysis of initiation of Helicobacter pylori chromosome replication.

2013/10/E/NZ1/00718

Keywords:

oriC DnaA initiation of chromosome replication cell signalling host-pathogen interations

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_4: Structural biology
  • NZ1_10: Microbiology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Pawlik 

Number of co-investigators in the project: 7

Call: SONATA BIS 3 - announced on 2013-06-14

Amount awarded: 1 500 000 PLN

Project start date (Y-m-d): 2014-06-10

Project end date (Y-m-d): 2020-12-09

Project duration:: 78 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. aparat do transferu biomolekuł (8 220 PLN)
  2. inkubator z możliwością wytrząsania (74 000 PLN)
  3. ACU Athmospheric Control Unit.
  4. Wirówka stołowa z rotorem 24x1,5/2ml.
  5. wirówka nastołowa z rotorem wychylnym (35 000 PLN)
  6. komora laminarna klasy II (40 000 PLN)
  7. komputer osobisty typu laptop (2 szt.) (7 000 PLN)
  8. komputery ososbiste typu laptop (2 szt.) (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Book publications / chapters in book publications (1)
  1. Streptomycete origin of chromosomal replication with two putative unwinding elements
    Authors:
    Małgorzata Płachetka, Dorota Żyła-Uklejewicz, Christoph Weigel, Rafał Donczew, Magdalena Donczew, Dagmara Jakimowicz, Anna Zawilak-Pawlik, Jolanta Zakrzewska-Czerwinska
    Academic press:
    Microbiology (rok: 2019, tom: 165, strony: 1365-1375), Wydawca: Microbiology Society
    Status:
    Published
    DOI:
    10.1099/mic.0.000859 - link to the publication
  2. Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations
    Authors:
    V.Anna Zawilak-Pawlik, Urszula Zarzecka, Dorota Żyła-Uklejewicz, Jakub Lach, Dominik Strapagiel, Nicole Tegtmeyer, Manja Böhm, Steffen Backert, Joanna Skorko-Glonek
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 11794), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-48030-6 - link to the publication
  3. Putative Cooperative ATP-DnaA Binding to Double-Stranded DnaA Box and Single-Stranded DnaA-Trio Motif upon Helicobacter pylori Replication Initiation Complex Assembly.
    Authors:
    Jaworski P, Zyla-Uklejewicz D, Nowaczyk-Cieszewska M, Donczew R, Mielke T, Weigel C, Zawilak-Pawlik A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6643), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126643 - link to the publication
  4. HP1021 is a redox switch protein identified in Helicobacter pylori.
    Authors:
    Szczepanowski, P.; Noszka, M.; Zdot;yła-Uklejewicz, D.; Pikuła, F.; Nowaczyk-Cieszewska, M.; Krȩżel, A.; Stingl, K.; Zawilak-Pawlik, A
    Academic press:
    Nucleic Acids Research (rok: 2021, tom: 49, strony: 6863-6879), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkab440 - link to the publication
  5. The role of Helicobacter pylori DnaA domain I in orisome assembly on a bipartite origin of chromosome replication
    Authors:
    Małgorzata Nowaczyk-Cieszewska, Dorota Żyła-Uklejewicz, Mateusz Noszka, Paweł Jaworski, Thorsten Mielke, Anna Zawilak-Pawlik.
    Academic press:
    Molecular Microbiology (rok: 2020, tom: 113, strony: 338–355), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/mmi.14423 - link to the publication
  6. The role of the N-terminal domain of bacterial initiator DnaA in the assembly and regulation of the bacterial replication initiation complex
    Authors:
    Zawilak-Pawlik A, Nowaczyk M, Zakrzewska-Czerwinska J
    Academic press:
    Genes (Basel) (rok: 2017, tom: 8, strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes8050136 - link to the publication
  7. Unique and universal features of Epsilonproteobacterial origins of chromosome replication and DnaA-DnaA box interactions.
    Authors:
    Jaworski P., Donczew R., Mielke T., Thiel M., Oldziej S., Weigel C., Zawilak-Pawlik A
    Academic press:
    Frontiers in Microbiology (rok: 2016, tom: 1,37152777777778, strony: 45305), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2016.01555 - link to the publication
  1. Recent advances in Helicobacter pylori replication: possible implications in adaptation to a pathogenic lifestyle and perspectives for drug design.
    Authors:
    Zawilak-Pawlik A., Zakrzewska-Czerwińska J
    Book:
    Molecular Pathogenesis and Signal Transduction by Helicobacter pylori w serii Current Topics in Microbiology and Immunology (rok: 2017, tom: 400, strony: 73-103), Wydawca: Springer
    Status:
    Published

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