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Comprehensive transcriptomic and epigenomic analysis of the genetically-defined pigs predisposed to colorectal cancer.

2013/10/M/NZ2/00284

Keywords

Descriptors

  • NZ2_2: Genomika, transkryptomika i epigenomika
  • NZ9_2: Naukowe podstawy zootechniki

Panel

NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Marek Zbigniew Świtoński

Number of co-investigators in the project: 10

Call

HARMONIA 5 – announced on 2013-06-14

Amount awarded
1 254 240 PLN
Project start date
2014-06-06
Project end date
2017-10-05
Project duration
40 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (5)

  1. The expression of TAP1 candidate gene, but not its polymorphism and methylation, is associated with colonic polyp formation in a porcine model of human familial adenomatous polyposis

    Authors:
    Perkowska A., Flisikowska T., Perleberg C., Flisikowski K., Stachowiak M., Nowacka-Woszuk J., Saur D., Kind A., Schnieke A., Switonski M.
    Academic press:
    Animal Biotechnology (year: 2019, volume: online early, pages: online early), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10495398.2019.1590377 – link to the publication

  2. Porcine FAP model enables systematic analysis of early events in adenoma progression

    Authors:
    Flisikowska T. , Stachowiak M. , Xu H. , Wagner A. , Hernández-Cáceres A. , Wurmser C. , Wander C. , Pausch H. , Fischer K., Perkowska A. , Frishman D., Fries R. , Switonski M. , Kind A. , Prof. Dieter Saur , Schnieke A., Flisikowski K.,
    Academic press:
    Scientific Reports (year: 2017, volume: 7, pages: 6613), Publisher: SPRINGER-NATURE
    Status:
    Published
    DOI:
    10.1038/s41598-017-06741-8 – link to the publication

  3. Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatouspolyposis

    Authors:
    Stachowiak M., Flisikowska T., Bauersachs S., Perleberg C., Pausch H., Switonski M., Kind A., Saur D., Schnieke A., Flisikowski K.
    Academic press:
    Oncotarget (year: 2017, volume: 8 (56), pages: 96154-96160), Publisher: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.21774 – link to the publication

  4. Elevated expression of p53 in early colon polyps in a pig model of human familial adenomatous polyposis

    Authors:
    Sikorska A., Flisikowska T., Stachowiak M., Kind A., Schnieke A., Flisikowski K, Switonski M.
    Academic press:
    Journal of Applied Genteics (year: 2018, volume: 59, pages: 485-491), Publisher: SPRINGER
    Status:
    Published
    DOI:
    10.1007/s13353-018-0461-6 – link to the publication

  5. Germline gene polymorphisms predisposing domestic mammals to carcinogenesis

    Authors:
    Flisikowski K, Flisikowska T, Sikorska A, Perkowska A, Kind A, Schnieke A, Switonski M.
    Academic press:
    Veterinary and Comparative Oncology (year: 2017, volume: 15(2), pages: 289-298), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/vco.12186 – link to the publication

Articles in post-conference publications (5)

  1. Polymorphism of TP53 and CSF1R genes in genetically modified pigs at the APC locus

    Authors:
    Sikorska A., Flisikowska T., Flisikowski K., Kind A., Schnieke A., Świtoński M.
    Conference:
    V Polski Kongres Genetyki (year: 2016, pages: 270), Publisher: Polskie Towarzystwo Genetyczne
    Date:
    conference 19-22.09.2016
    Status:
    Published

  2. Poziom ekspresji wybranych genów u zmodyfikowanych genetycznie swiń APC1311 z różnym tempem rozwoju polipów w jelicie grubym

    Authors:
    Stachowiak M, Flisikowska T., Wender C., Perkowska A., Sikorska A., Kind A., Schnieke A., Flisikowski K., Switonski M.
    Conference:
    Zjazd Katedr Jednoimiennych Genetyki i Metod Hodowli Zwierząt (year: 2017, pages: 25), Publisher: Uniwersytet Przyrodniczy w Lublinie
    Date:
    conference 3 - 5 lipca
    Status:
    Published

  3. Precancerous molecular features committing development of colonic polyps revealed by studies on the porcine model of human familial adenomatous polyposis

    Authors:
    Flisikowska T., Wander C., Wagner A., Bruening F., Kind A., Flisikowski K., Schnieke A., Wurmser C., Fries R., Stachowiak M., Perkowska A., Switonski M., Bauersachs S., Saur D.
    Conference:
    35th International Society for Animal Genetics Conference (year: 2016, pages: 179-180), Publisher: International Society for Animal Genetics
    Date:
    conference 23.07.16 – 27.07.2016
    Status:
    Published

  4. Precancerous molecular features committing development of colonic polyps – studies with APC1311-targeted pigs

    Authors:
    Flisikowski K., Flisikowska T., Dragan-Stachowiak M., Wander C., Wagner A., Wurmser Ch., Perkowska A., Bauersachs S., Kind A., Fries R., Świtoński M., Saur D., Schnieke A
    Conference:
    V Polski Kongres Genetyki (year: 2016, pages: 116), Publisher: Polskie Towarzystwo Genetyczne
    Date:
    conference 19-22.09.2016
    Status:
    Published

  5. Comparative sequence analysis of APC and TAP1 genes in genetically modified pig-models for human colorectal cancer

    Authors:
    Perkowska A., Flisikowska T., Flisikowski K., Kind A., Schnieke A., Świtoński M.
    Conference:
    V Polski Kongres Genetyki (year: 2016, pages: 265), Publisher: Polskie Towarzystwo Genetyczne
    Date:
    conference 19-22.09.2016
    Status:
    Published

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