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The key mechanizm for the development of allergy to nickel: A role of the filaggrin fragments, a potential carrier protein for the nickel haptens in the induction of an allergic reaction to nickel in a model of dendritic cell line in vitro.

2013/09/N/NZ6/02405

Keywords:

Filaggrin (FLG) allergy to nickel dendritic cells nickel-dependent peptide bond hydrolysis

Descriptors:

  • NZ7_15: Toxicology
  • ST5_16:
  • NZ6_8: Other related subjects

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Ewa Podobas 

Number of co-investigators in the project: 2

Call: PRELUDIUM 5 - announced on 2013-03-15

Amount awarded: 74 640 PLN

Project start date (Y-m-d): 2014-03-25

Project end date (Y-m-d): 2016-07-24

Project duration:: 28 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (1)
  1. Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences
    Authors:
    E.I. Podobas, D. Gutowska-Owsiak, S. Moretti, J. Poznański, M. Kulińczak, M. Grynberg, A. Gruca, A. Bonna, D. Płonka, G. Ogg, W. Bal
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2022, tom: 9:828674, strony: 0,0527777777777778), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2022.828674 - link to the publication
  1. NICKEL(II) IONS INTERACTIONS WITH FILAGGRIN PROTEIN IN THE LIGHT OF THE ROLE OF Ni(II)-ASSISTED PEPTIDE BOND HYDROLYSIS IN NICKEL SENSITIZATION
    Authors:
    Ewa Izabela Podobas, Yi-Ling Chen, Arkadiusz Bonna, Danuta Gutowska-Owsiak, Graham Ogg, Wojciech Bal
    Conference:
    13th European Biological Inorganic Chemistry Conference (rok: 2016, ), Wydawca: Hungarian Chemical Society
    Data:
    konferencja 28.08-01.09.2016
    Status:
    Published

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