The key mechanizm for the development of allergy to nickel: A role of the filaggrin fragments, a potential carrier protein for the nickel haptens in the induction of an allergic reaction to nickel in a model of dendritic cell line in vitro.
2013/09/N/NZ6/02405
Keywords
Descriptors
- NZ7_15: Toksykologia
- ST5_16: Chemia biologiczna
- NZ6_8: Inne zagadnienia pokrewne
Panel
NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution
Instytut Biochemii i Biofizyki PAN
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 5 – announced on 2013-03-15
- Amount awarded
- 74 640 PLN
- Project start date
- 2014-03-25
- Project end date
- 2016-07-24
- Project duration
- 28 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (1)
-
Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences
- Authors:
- E.I. Podobas, D. Gutowska-Owsiak, S. Moretti, J. Poznański, M. Kulińczak, M. Grynberg, A. Gruca, A. Bonna, D. Płonka, G. Ogg, W. Bal
- Academic press:
- Frontiers in Molecular Biosciences (year: 2022, volume: 9:828674, pages: 0,0527777777777778), Publisher: Frontiers
- Status:
- Published
- DOI:
- 10.3389/fmolb.2022.828674 – link to the publication
Articles in post-conference publications (1)
-
NICKEL(II) IONS INTERACTIONS WITH FILAGGRIN PROTEIN IN THE LIGHT OF THE ROLE OF Ni(II)-ASSISTED PEPTIDE BOND HYDROLYSIS IN NICKEL SENSITIZATION
- Authors:
- Ewa Izabela Podobas, Yi-Ling Chen, Arkadiusz Bonna, Danuta Gutowska-Owsiak, Graham Ogg, Wojciech Bal
- Conference:
- 13th European Biological Inorganic Chemistry Conference (year: 2016, pages: 282), Publisher: Hungarian Chemical Society
- Date:
- conference 28.08-01.09.2016
- Status:
- Published