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Synthesis and photocytotoxicity against microorganizms porphyrinoids peripherally modified with morpholin groups

2013/09/N/NZ7/01454

Keywords:

photosensitizer morpholin microbiology photodynamic antimicrobial chemotherapy

Descriptors:

  • NZ6_4: Bacteriology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Wojciech Szczołko 

Number of co-investigators in the project: 3

Call: PRELUDIUM 5 - announced on 2013-03-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2014-02-13

Project end date (Y-m-d): 2017-02-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (7)
  1. Antimicrobial and anticancer photodynamic activity of a phthalocyanine photosensitizer with N-methyl morpholiniumethoxy substituents in non-peripheral positions
    Authors:
    Jolanta Dlugaszewska, Wojciech Szczolko, Tomasz Koczorowski, Paulina Skupin- Mrugalska, Anna Teubert, Krystyna Konopka, Malgorzata Kucinska, Marek Murias, Nejat Düzgüneş, Jadwiga Mielcarek and Tomasz Goslinski
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2017, tom: 172, strony: 67-79), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.jinorgbio.2017.04.009 - link to the publication
  2. Physicochemical properties of liposome-incorporated 2-(morpholin-4-yl)ethoxy phthalocyanines and their photodynamic activity against oral cancer cells
    Authors:
    Paulina Skupin-Mrugalska, Wojciech Szczolko, Piotr Gierlich, Krystyna Konopka, Tomasz Goslinski, Jadwiga Mielcarek, Nejat Düzgüneş
    Academic press:
    Journal of Photochemistry and Photobiology A: Chemistry (rok: 2018, tom: 353, strony: 445-457), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.jphotochem.2017.12.005 - link to the publication
  1. Antimicrobial and anticancer photodynamic activity of phthalocyanine photosensitizer possessing non-peripheral 2-(morpholin-4-yl)ethoxy substituents
    Authors:
    Dlugaszewska Jolanta, Szczolko Wojciech, Koczorowski Tomasz, Skupin - Mrugalska Paulina, Wzgarda Anna, Konopka Krystyna, Nejat Düzgüneş, Mielcarek Jadwiga and Goslinski Tomasz
    Conference:
    Symposium on Advances in Heterocyclic Organic Chemistry SAHOC 2016 (rok: 2016, ), Wydawca: University of Sheffield
    Data:
    konferencja 1-2 września
    Status:
    Published
  2. Synthesis, characterization and biological propertis of water soluble phthalocyanine possesing morpholinethoxy groups
    Authors:
    Szczolko W, Koczorowski T, Dlugaszewska J, Tykarska E, Teubert A, Gdaniec M, Goslinski T.
    Conference:
    VI Konwersatorium Chemii Medycznej w Lublinie (rok: 2014, ), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 18-20 września
    Status:
    Published
  3. Synthesis of water-soluble porphyrazines possessing peripheral 2-(4-methylmorpholin-4-ium-4-yl)ethylsulfanyl substituents as potential photosensitizers in PACT.
    Authors:
    W[ojciech] Szczołko, Tomasz Koczorowski, Jolanta Długaszewska, Tomasz Gośliński.
    Conference:
    8th Polish-German Symposium on Pharmaceutical Science "Retrospects, insights and prospects". Kiel, Germany, (rok: 2015, ), Wydawca: Kiel University
    Data:
    konferencja 29th - 30th May 2015.
    Status:
    Published
  4. Porphyrazines possessing peripheral 2-(morpholin-4-yl)ethylsulfanyl substituents - synthesis and characterization of novel potential photosensitizers.
    Authors:
    Tomasz Koczorowski, Wojciech Szczołko, Paulina Skupin-Mrugalska, Jadwiga Mielcarek, Tomasz Gośliński.
    Conference:
    8th Polish-German Symposium on Pharmaceutical Science "Retrospects, insights and prospects". Kiel, Germany, (rok: 2015, ), Wydawca: Kiel University
    Data:
    konferencja 29th - 30th May 2015.
    Status:
    Published
  5. Synthesis of water-soluble magnesium porphyrazine possessing peripheral 2-(4-methylmorpholin-4-ium-4-yl)ethylsulfanyl substituents as potential photosensitizers in PACT
    Authors:
    Wojciech Szczołko, Tomasz Koczorowski, Jolanta Długaszewska, Tomasz Gośliński.
    Conference:
    23rd Young Research Fellow Meeting. Lille, France, (rok: 2016, ), Wydawca: School of Pharmacy, Lille, France
    Data:
    konferencja February 15-17, 2016.
    Status:
    Published
  6. Novel magnesium phthalocyanine possesing quaternized 2-(morpholin-4-yl)ethoxy groups as potential photosensitizer in PACT.
    Authors:
    W[ojciech] Szczołko, T[omasz] Koczorowski, J[olanta] Długaszewska, E[wa] Tykarska, A[nna] Teubert, T[omasz] Gośliński.
    Conference:
    16th Blue Danube Symposium on Heterocyclic Chemistry. Balatonalmádi, Hungary, June 14-17, 2015. (rok: 2015, ), Wydawca: Hungarian Chemical Society 2015
    Data:
    konferencja June 14-17, 2015
    Status:
    Published
  7. Novel zinc porphyrazine possesing peripheral 2-(morpholin-4-yl)ethylsulfanyl substituents as potential photosensitizer for PACT.
    Authors:
    Tomasz Koczorowski, Wojciech Szczołko, Jolanta Długaszewska, Paulina Skupin-Mrugalska, Jadwiga Mielcarek, Tomasz Gośliński.
    Conference:
    16th Blue Danube Symposium on Heterocyclic Chemistry. Balatonalmádi, Hungary, June 14-17, 2015. (rok: 2015, ), Wydawca: Hungarian Chemical Society 2015
    Data:
    konferencja June 14-17, 2015
    Status:
    Published

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