Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The involvement of P2 purinergic receptors in alpha-synuclein mediated mitochondrial dysfunction. Relevance to Parkinson's disease.

2013/09/D/NZ3/01359

Keywords:

alpha synuclein purinergic receptors mitochondrial dysfunction Parkinson's disease

Descriptors:

  • NZ3_4: Ageing
  • NZ3_6: Cell neurobiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Wilkaniec 

Number of co-investigators in the project: 5

Call: SONATA 5 - announced on 2013-03-15

Amount awarded: 362 706 PLN

Project start date (Y-m-d): 2014-02-17

Project end date (Y-m-d): 2016-12-16

Project duration:: 34 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. komputer ze specjalistycznym oprogramowaniem (GrapPad Prism, EndNote) (8 000 PLN)
  2. inkubator do hodowli mikrobiologicznej z naturalnym obiegiem powietrza (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (10)
  1. Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson's Disease Etiopathology.
    Authors:
    Anna Wilkaniec, Anna M. Lenkiewicz, Grzegorz A. Czapski, Henryk M. Jęśko, Wojciech Hilgier, Robert Brodzik, Magdalena Gąssowska-Dobrowolska, Carsten Culmsee, Agata Adamczyk
    Academic press:
    Molecular Neurobiology (rok: 2018, ), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s12035-018-1082-0. - link to the publication
  2. P2X7 receptor-Pannexin1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells
    Authors:
    Anna Wilkaniec, Magdalena Gąssowska, Grzegorz A. Czapski, Magdalena Cieślik, Grzegorz Sulkowski, Agata Adamczyk
    Academic press:
    Purinergic Signalling (rok: 2017, tom: 13, strony: 347-361), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11302-017-9567-2. - link to the publication
  1. Purinergic P2 receptors activation mediates neuroblastoma SH-SY5Y cell death evoked by extracellular a-synuclein
    Authors:
    Anna Wilkaniec, Magdalena Cieślik, Magdalena Gąssowska, Anna M. Lenkiewicz, Grzegorz A. Czapski, Agata Adamczyk
    Conference:
    12th International Symposium Molecular basis of pathology and therapy in neurological disorders" (rok: 2014, ), Wydawca: Folia Neuropathologica (Termedia)
    Data:
    konferencja 20-21 listopad
    Status:
    Published
    DOI:
    link to the publication
  2. The interplay between Purinergic signaling and the toxicity of extracellular alpha-synuclein.
    Authors:
    Anna Wilkaniec, Magdalena Cieślik, Magdalena Gąssowska, Henryk Jęśko, Grzegorz A. Czapski, Anna Lenkiewicz, Agata Adamczyk.
    Conference:
    25th ISN Biennial Meeting (rok: 2015, ), Wydawca: Journal of Neurochemistry (Wiley)
    Data:
    konferencja 23-27 sierpień
    Status:
    Published
    DOI:
    link to the publication
  3. α-Synuclein and its role in synaptic function
    Authors:
    Anna Wilkaniec
    Conference:
    Neurochemical Conference 2015, The Days of Neurochemistry Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases: From biomarkers to therapeutics" (rok: 2015, ), Wydawca: Folia Neuropathologica (Termedia)
    Data:
    konferencja 22-23 październik
    Status:
    Published
    DOI:
    link to the publication
  4. Extracellular oligomers of alpha-Synuclein induces Parkin modifications and dopaminergic PC12 cells death
    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    27th ECNP Congress (rok: 2014, ), Wydawca: European Neuropsychopharmacology (Elsevier)
    Data:
    konferencja 18-21 październik
    Status:
    Published
    DOI:
    link to the publication
  5. Overexpression of parkin protects PC12 cells against alpha-synuclein evoked mitochondria damage and cell death
    Authors:
    Lenkiewicz A.M., Wilkaniec A., Adamczyk A.
    Conference:
    The 13th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS The 4th International Conference STEM CELLS: THERAPEUTIC OUTLOOK FOR CENTRAL NERVOUS SYSTEM DISORDERS (rok: 2016, ), Wydawca: Termedia
    Data:
    konferencja 17-18 listopad
    Status:
    Published
    DOI:
    link to the publication
  6. P2X7 receptor mediates extracellular alpha-synuclein-induced mitochondrial dysfunction in neuroblastoma SH-SY5Y cells.
    Authors:
    Anna Wilkaniec, Anna M. Lenkiewicz, Grzegorz A. Czapski, Grzegorz Sulkowski, Agata Adamczyk.
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Nencki Institute of Experimental Biology Polish Neuroscience Society
    Data:
    konferencja 28-31 sierpień
    Status:
    Published
    DOI:
    link to the publication
  7. Aberrant purinergic signalling contributes to neurodegeneration and mitochondrial impairment induced by alpha-synuclein.
    Authors:
    Anna Wilkaniec, Anna M. Lenkiewicz, Agata Adamczyk
    Conference:
    The Neurochemical Conference 2017 "Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: Termedia
    Data:
    konferencja 19-20 październik
    Status:
    Published
  8. Purinergic P2X7 receptor is involved in alpha-synuclein-mediated neuronal cell death via dysregulation of PI3K/AKT and AMPK-mTOR signaling pathways
    Authors:
    Wilkaniec A., Gąssowska M., Sulkowski G.,Czapski G.A., Adamczyk A.
    Conference:
    Polish-French scientific conference: Alzheimer's disease and neurodegenerative disorders: what challenges for tomorrow? (rok: 2016, ), Wydawca: Termedia
    Data:
    konferencja 4 listopada
    Status:
    Published
    DOI:
    link to the publication
  9. Cytoprotective role of Parkin against alpha- Synuclein evoked mitochondrial failure in PC12 cells. Relevance to Parkinson's disease and other neurodegenerative disorders.
    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    The Neurochemical Conference 2017 "Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: Termedia
    Data:
    konferencja 19-20 Październik
    Status:
    Published
  10. The involvement of purinergic signaling in mitochondria dysfunction induced by alpha synuclein
    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    12th INTERNATIONAL CONGRESS OF THE POLISH NEUROSCIENCE SOCIETY (rok: 2015, ), Wydawca: Acta Neurobiologiae Experimentalis (Nencki Institute of Experimental Biology)
    Data:
    konferencja 6-8 wrzesień
    Status:
    Published
    DOI:
    link to the publication

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