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The involvement of P2 purinergic receptors in alpha-synuclein mediated mitochondrial dysfunction. Relevance to Parkinson's disease.

2013/09/D/NZ3/01359

Keywords

Descriptors

  • NZ3_4: Starzenie
  • NZ3_6: Neurobiologia komórkowa
  • NZ3_7: Przekaźnictwo sygnału

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Anna Wilkaniec

Number of co-investigators in the project: 5

Call

SONATA 5 – announced on 2013-03-15

Amount awarded
362 706 PLN
Project start date
2014-02-17
Project end date
2016-12-16
Project duration
34 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. inkubator do hodowli mikrobiologicznej z naturalnym obiegiem powietrza. Cost: 12 000 PLN
  2. komputer ze specjalistycznym oprogramowaniem (GrapPad Prism, EndNote). Cost: 8 000 PLN

Information in the final report

Publication in academic press/journals (2)

  1. P2X7 receptor-Pannexin1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells

    Authors:
    Anna Wilkaniec, Magdalena Gąssowska, Grzegorz A. Czapski, Magdalena Cieślik, Grzegorz Sulkowski, Agata Adamczyk
    Academic press:
    Purinergic Signalling (year: 2017, volume: 13, pages: 347-361), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11302-017-9567-2. – link to the publication

  2. Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson's Disease Etiopathology.

    Authors:
    Anna Wilkaniec, Anna M. Lenkiewicz, Grzegorz A. Czapski, Henryk M. Jęśko, Wojciech Hilgier, Robert Brodzik, Magdalena Gąssowska-Dobrowolska, Carsten Culmsee, Agata Adamczyk
    Status:
    Accepted for publication

Articles in post-conference publications (10)

  1. Purinergic P2X7 receptor is involved in alpha-synuclein-mediated neuronal cell death via dysregulation of PI3K/AKT and AMPK-mTOR signaling pathways

    Authors:
    Wilkaniec A., Gąssowska M., Sulkowski G.,Czapski G.A., Adamczyk A.
    Conference:
    Polish-French scientific conference: Alzheimer's disease and neurodegenerative disorders: what challenges for tomorrow? (year: 2016, pages: 429), Publisher: Termedia
    Date:
    conference 4 listopada
    Status:
    Published
    DOI:
    link to the publication

  2. Purinergic P2 receptors activation mediates neuroblastoma SH-SY5Y cell death evoked by extracellular a-synuclein

    Authors:
    Anna Wilkaniec, Magdalena Cieślik, Magdalena Gąssowska, Anna M. Lenkiewicz, Grzegorz A. Czapski, Agata Adamczyk
    Conference:
    12th International Symposium Molecular basis of pathology and therapy in neurological disorders (year: 2014, pages: 365), Publisher: Folia Neuropathologica (Termedia)
    Date:
    conference 20-21 listopad
    Status:
    Published
    DOI:
    link to the publication

  3. Aberrant purinergic signalling contributes to neurodegeneration and mitochondrial impairment induced by alpha-synuclein.

    Authors:
    Anna Wilkaniec, Anna M. Lenkiewicz, Agata Adamczyk
    Conference:
    The Neurochemical Conference 2017 Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches (year: 2017, pages: 258), Publisher: Termedia
    Date:
    conference 19-20 październik
    Status:
    Published

  4. The interplay between Purinergic signaling and the toxicity of extracellular alpha-synuclein.

    Authors:
    Anna Wilkaniec, Magdalena Cieślik, Magdalena Gąssowska, Henryk Jęśko, Grzegorz A. Czapski, Anna Lenkiewicz, Agata Adamczyk.
    Conference:
    25th ISN Biennial Meeting (year: 2015, pages: 136), Publisher: Journal of Neurochemistry (Wiley)
    Date:
    conference 23-27 sierpień
    Status:
    Published
    DOI:
    link to the publication

  5. Cytoprotective role of Parkin against alpha- Synuclein evoked mitochondrial failure in PC12 cells. Relevance to Parkinson's disease and other neurodegenerative disorders.

    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    The Neurochemical Conference 2017 Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches (year: 2017, pages: 255), Publisher: Termedia
    Date:
    conference 19-20 Październik
    Status:
    Published

  6. P2X7 receptor mediates extracellular alpha-synuclein-induced mitochondrial dysfunction in neuroblastoma SH-SY5Y cells.

    Authors:
    Anna Wilkaniec, Anna M. Lenkiewicz, Grzegorz A. Czapski, Grzegorz Sulkowski, Agata Adamczyk.
    Conference:
    13th International Congress of Polish Neuroscience Society (year: 2017, pages: LXV), Publisher: Nencki Institute of Experimental Biology Polish Neuroscience Society
    Date:
    conference 28-31 sierpień
    Status:
    Published
    DOI:
    link to the publication

  7. Overexpression of parkin protects PC12 cells against alpha-synuclein evoked mitochondria damage and cell death

    Authors:
    Lenkiewicz A.M., Wilkaniec A., Adamczyk A.
    Conference:
    The 13th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS The 4th International Conference STEM CELLS: THERAPEUTIC OUTLOOK FOR CENTRAL NERVOUS SYSTEM DISORDERS (year: 2016, pages: 318), Publisher: Termedia
    Date:
    conference 17-18 listopad
    Status:
    Published
    DOI:
    link to the publication

  8. α-Synuclein and its role in synaptic function

    Authors:
    Anna Wilkaniec
    Conference:
    Neurochemical Conference 2015, The Days of Neurochemistry Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases: From biomarkers to therapeutics (year: 2015, pages: 409), Publisher: Folia Neuropathologica (Termedia)
    Date:
    conference 22-23 październik
    Status:
    Published
    DOI:
    link to the publication

  9. Extracellular oligomers of alpha-Synuclein induces Parkin modifications and dopaminergic PC12 cells death

    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    27th ECNP Congress (year: 2014, pages: S628–S629), Publisher: European Neuropsychopharmacology (Elsevier)
    Date:
    conference 18-21 październik
    Status:
    Published
    DOI:
    link to the publication

  10. The involvement of purinergic signaling in mitochondria dysfunction induced by alpha synuclein

    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    12th INTERNATIONAL CONGRESS OF THE POLISH NEUROSCIENCE SOCIETY (year: 2015, pages: S99), Publisher: Acta Neurobiologiae Experimentalis (Nencki Institute of Experimental Biology)
    Date:
    conference 6-8 wrzesień
    Status:
    Published
    DOI:
    link to the publication

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