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The orexin activatory mechanism on neurons in the intergeniculate leaflet of the thalamus - the mammalian biological clock oscillator

2013/09/B/NZ4/00541

Keywords:

orexins intergeniculate leaflet biological clock

Descriptors:

  • NZ4_7: Neurophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marian Lewandowski 

Number of co-investigators in the project: 4

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 411 868 PLN

Project start date (Y-m-d): 2014-03-05

Project end date (Y-m-d): 2017-03-04

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer stacjonarny do analizy danych.
  2. Kontroler ciśnieniowy Ez-gSEAL100B firmy Neo Biosystem (19 000 PLN)
  3. Niskoszumowy przedwzmacniacz (SEC HSP) firmy NPI Company (4 500 PLN)
  4. Komputer stacjonarny do analizy danych (8 600 PLN)
  5. Zestaw do mikroskopu fluorescencyjnego (statyw, rewolwer, obiektyw 6x, HD DIC, M27 mot, Migawka światła przechodzącego (21 815 PLN)
  6. Mikrośilnik AnyXing 300D.
  7. System do mikroinfuzji SmartSquirt® fiimy AutoMate Scientific (14 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (12)
  1. Orexins/hypocretins modulate the activity of NPY-positive and -negative neurons in the rat intergeniculate leaflet via OX1 and OX2 receptors.
    Authors:
    Palus K., Chrobok L., Lewandowski MH.
    Academic press:
    Neuroscience (rok: 2015, tom: 300, strony: 370–380), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2015.05.039 - link to the publication
  2. Enkephalin and neuropeptide-Y interaction in the intergeniculate leaflet network, a part of the mammalian biological clock.
    Authors:
    Palus K, Chrobok L, Kepczynski M, Lewandowski MH
    Academic press:
    Neuroscience (rok: 2017, tom: 343, strony: 45585), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2016.11.034 - link to the publication
  3. Orexins excite ventrolateral geniculate nucleus neurons predominantly via OX2 receptors
    Authors:
    Chrobok L, Palus K, Lewandowski MH.
    Academic press:
    Neuropharmacology (rok: 2016, tom: 103, strony: 236-246), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2015.12.008. - link to the publication
  4. Orexin –A depolarizes rat intergeniculate leaflet neurons through nonselective cations channels.
    Authors:
    Palus-Chramiec K, Chrobok L, Kepczynski M, Lewandowski MH
    Academic press:
    Neuroscience (rok: 2019, tom: -, strony: -), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal
    Authors:
    Chrobok L, Palus K, Chrzanowska A, Kepczynski M, Lewandowski MH
    Academic press:
    Scientific Reports (rok: 2017, tom: 1, strony: 7713), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-017-08202-8 - link to the publication
  1. ELECTROPHYSIOLOGICAL APPROACH TO IDENTIFICATION THE TWO MAIN POPULATION OF THE INTERGENICULATE LEAFLET NEURONS AND THEIR SENSITIVITY TO OREXIN-A
    Authors:
    K. Palus, L Chrobok, M.H. Lewandowski
    Conference:
    9th FENS Forum of Neuroscience, Mediolan, Włochy (rok: 2014, ), Wydawca: brak
    Data:
    konferencja 5-9 lipiec
    Status:
    Published
    DOI:
    link to the publication
  2. Orexin-A depolarises dorsolateral geniculate nucleus neurons via pre- and postsynaptic orexin receptors
    Authors:
    Chrobok L., Palus K., Lewandowski MH
    Conference:
    10th FENS Forum of Neuroscience (rok: 2016, ), Wydawca: brak
    Data:
    konferencja 2-6 Lipiec
    Status:
    Published
  3. Orexins/Hypocretins modulate the activity of NPY-positive and -negative neurons in the rat intergeniculate leaflet via OX1 and OX2 receptors
    Authors:
    K. Palus, L Chrobok, M.H. Lewandowski
    Conference:
    XIV European Biological Rhythms Society (EBRS) and IV World Congress of Chronobiology (WCC) (rok: 2015, ), Wydawca: The University of Manchaster
    Data:
    konferencja 2-6 Sierpień
    Status:
    Published
  4. Unraveling the orexins distribution pattern in rat lateral geniculate nucleus of the thalamus
    Authors:
    Anna Chrzanowska, Łukasz Chrobok, Katarzyna Palus,
    Conference:
    Neuronus 2016 IBRO and IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus
    Data:
    konferencja 22-24 Kwiecień
    Status:
    Published
  5. Direct effect of orexin a on the dorsal part of rat lateral geniculate body
    Authors:
    L. Chrobok, K. Palus, P. Grubba, M.H. Lewandowski
    Conference:
    Molecular and physiological aspects of regulatory processes of the organism (rok: 2014, ), Wydawca: Abaton, Kraków
    Data:
    konferencja 26-27 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  6. Orexins excite the neurons of the rat ventral lateral geniculate nucleus predominantly via OX2 receptors
    Authors:
    Palus K., Chrobok L., Lewandowski MH.
    Conference:
    12th International Congress of Polish Neuroscience Society (rok: 2015, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 6-8 wrzesień
    Status:
    Published
  7. Possible link between arousal and vision: orexin-A facilitates inputs to the dorsolateral geniculate nucleus neurons in rat
    Authors:
    Chrobok L., Palus K., Lewandowski MH.
    Conference:
    Time and Light: Novel Concepts and Models in Sensory and Chronobiology (rok: 2016, ), Wydawca: Uniwersytet Wiedeński
    Data:
    konferencja 8-10 Maj
    Status:
    Published
  8. Activation of the dorsal lateral geniculate nucleus (dlgn) neurons by orexin a – invivo study on urethane-anesthetised rats.
    Authors:
    Orlowska-Feuer P, Dyl K, Lewandowski MH
    Conference:
    XIV European Biological Rhythms Society (EBRS) and IV World Congress of Chronobiology (WCC) (rok: 2015, ), Wydawca: The University of Manchaster
    Data:
    konferencja 2-6 Sierpień
    Status:
    Published
  9. Orexin-A depolarize the rat intergeniculate leaflet neurons via two different mechanisms
    Authors:
    Palus K., Chrobok L., Lewandowski MH
    Conference:
    Neuronus 2016 IBRO and IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus
    Data:
    konferencja 22-24 Kwiecień
    Status:
    Published
  10. Ionic mechanism activated by the orexin-A in the rat dorsolateral geniculate nucleus neurons
    Authors:
    Palus K., Chrobok L., Lewandowski MH.
    Conference:
    10th FENS Forum of Neuroscience (rok: 2016, ), Wydawca: brak
    Data:
    konferencja 2-6 Lipiec
    Status:
    Published
  11. Orexin A excites the ventrolateral geniculate nucleus neurons in the rat
    Authors:
    K. Palus, L Chrobok, P. Grubba, M.H. Lewandowski
    Conference:
    Molecular and physiological aspects of regulatory processes of the organism (rok: 2014, ), Wydawca: Abaton, Kraków
    Data:
    konferencja 26-27 wrzesień
    Status:
    Published
  12. Orexins excite the dorsal lateral geniculate nucleus neurons in pigmented and albino rats
    Authors:
    Chrobok L., Palus K., Lewandowski MH.
    Conference:
    12th International Congress of Polish Neuroscience Society (rok: 2015, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 6-8 wrzesień
    Status:
    Published

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