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A study of the polymorphism of active pharaceutical ingredients in term of its influence on their chemical stability and reactivity

2013/09/D/NZ7/02525

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Judyta Cielecka-Piontek

Number of co-investigators in the project: 7

Call

SONATA 5 – announced on 2013-03-15

Amount awarded
488 300 PLN
Project start date
2014-02-24
Project end date
2018-08-23
Project duration
54 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Akcesoria do analiz chromatograficznych. Cost: 5 000 PLN
  2. Akcesoria do analiz chromatograficznych. Cost: 10 000 PLN
  3. Chromatograf cieczowy.
  4. Komputer z oprogramowaniem. Cost: 7 000 PLN
  5. Spektrofotometr Ramana. Cost: 250 000 PLN
  6. Waga analityczna. Cost: 10 000 PLN
  7. Zestaw komputerowy z oprogramowaniem. Cost: 10 000 PLN

Information in the final report

Publication in academic press/journals (10)

  1. Prediction of HPLC retention times of tebipenem pivoxyl and its degradation products in solid state by applying adaptive artificial neural network with recursive features elimination

    Authors:
    Mikołaj Mizera, Alicja Talaczyńska, Przemysław Zalewski, Robert Skibiński, Judyta Cielecka-Piontek
    Academic press:
    Talanta (year: 2015, volume: 137, pages: 174–181), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.talanta.2015.01.032 – link to the publication

  2. Application of Vibrational Spectroscopy Supported by Theoretical Calculations in Identification of Amorphous and Crystalline Forms of Cefuroxime Axetil

    Authors:
    Alicja Talaczyńska, Kornelia Lewandowska, Anna Jelińska, Piotr Garbacki, Agnieszka Podborska, Przemysław Zalewski, Irena Oszczapowicz, Adam Sikora, Maciej Kozak, Judyta Cielecka-Piontek
    Academic press:
    The Scientific World Journal (year: 2015, volume: 2015, pages: 8 pages), Publisher: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    link to the publication

  3. Solid-state stability studies of crystal form of tebipenem

    Authors:
    Alicja Talaczyńska, Kornelia Lewandowska, Piotr Garbacki, Przemysław Zalewski, Robert Skibiński, Andrzej Miklaszewski, Mikołaj Mizera, Judyta Cielecka-Piontek
    Academic press:
    Drug Development and Industrial Pharmacy (year: 2015, volume: 42, pages: 238-244), Publisher: Informa Pharmaceutical Science
    Status:
    Published
    DOI:
    10.3109/03639045.2015.1044902 – link to the publication

  4. Benefits and limitations of polymorphic and amorphous forms of active pharmaceutical ingredients

    Authors:
    Alicja Talaczyńska, Jakub Dzitko, Judyta Cielecka-Piontek
    Academic press:
    Current Pharmaceutical Design (year: 2016, volume: 22, pages: 4975 - 4980), Publisher: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1381612822666160804100036 – link to the publication

  5. Studies of the crystalline form of cefuroxime axetil: Implications for its compatibility with excipients

    Authors:
    Alicja Talaczyńska, Mikołaj Mizera, Mirosław Szybowicz, Ariadna B Nowicka, Piotr Garbacki, Magdalena Paczkowska, Przemysław Zalewski, Maciej Kozak, Irena Oszczapowicz, Anna Jelińska, Judyta Cielecka-Piontek
    Academic press:
    Acta Poloniae Pharmaceutica – Drug Research (year: 2016, volume: 73 (5), pages: 1299 - 1309), Publisher: Polskiego Towarzystwa Farmaceutycznego
    Status:
    Published

  6. Computational study of influence of diffuse basis functions on geometry optimization and spectroscopic properties of losartan potassium

    Authors:
    Mikołaj Mizera, Kornelia Lewadowska, Alicja Talaczyńska, Judyta Cielecka-Piontek
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (year: 2015, volume: 137, pages: 1029–1038), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.saa.2014.09.036 – link to the publication

  7. ULTRA FAST HPLC METHOD FOR DETERMINATION OF RANITIDINE HYDROCHLORIDE USING A CORE-SHELL COLUMN

    Authors:
    KAMIL CZERNIAK, JUDYTA CIELECKA-PIONTEK, PRZEMYSŁAW ZALEWSKI
    Academic press:
    ACTA POLONIAE PHARMACEUTICA – DRUG RESEARCH (year: 2017, volume: 74 (6), pages: brak), Publisher: Polish Pharmaceutical Society
    Status:
    Published

  8. Vibrational (FT-IR, Raman) and DFT analysis on the structure of labile drugs. The case of crystalline tebipenem and its ester

    Authors:
    Magdalena Paczkowska, Mikołaj Mizera, Jakub Dzitko, Kornelia Lewandowska, Przemysław Zalewski Judyta Cielecka-Piontek
    Academic press:
    Journal of Molecular Structure (year: 2017, volume: 1134, pages: 135-142), Publisher: Elservier
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2016.12.074 – link to the publication

  9. The Analysis of the Physicochemical Properties of Benzocaine Polymorphs

    Authors:
    Magdalena Paczkowska, Gabriela Wiergowska, Andrzej Miklaszewski, Anna Krause, Magdalena Mroczkowka, Przemysław Zalewski and Judyta Cielecka-Piontek
    Academic press:
    Molecules (year: 2018, volume: brak, pages: 46035), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23071737 – link to the publication

  10. Assay of Diastereoisomers of Cefuroxime Axetil in Amorphous and Crystalline Forms Using UHPLC-DAD

    Authors:
    Piotr Garbacki, Artur Teżyk, Przemysław Zalewski, Anna Jelińska, Magdalena Paczkowska, Alicja Talczyńska, Irena Oszczapowicz, Judyta Cielecka-Piontek
    Academic press:
    Chromatographia (year: 2014, volume: 77, pages: 1489–1495), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s10337-014-2773-y – link to the publication

Articles in post-conference publications (18)

  1. Combined experimental and theoretical characterization of naratriptan hydrochloride

    Authors:
    Cielecka-Piontek J, Mizera M, Talaczyńska A, Paczkowska M, Lewandowska K, Szybowicz M, Krause A
    Conference:
    8th International Conference on Advanced Vibrational Spectroscopy (ICAVS8 2015) (year: 2015, pages: 408-409), Publisher: 8th International Conference on Advanced Vibrational Spectroscopy (ICAVS8 2015)
    Date:
    conference 12-17.07.2015
    Status:
    Published

  2. Zastosowanie technik spektralnych w badaniu postaci polimorficznych paracetamolu

    Authors:
    Cielecka-Piontek J, Lewandowska K, Kozak M, Garbacki P, Zalewski P, Talaczyńska A, Mizera M, Paczkowska M, Podborska A
    Conference:
    Nowoczesne techniki badawcze stosowane w analizie farmaceutycznej i biomedycznej (year: 2014, pages: brak numeracji stron), Publisher: Wydział Farmaceutyczny Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy
    Date:
    conference 10-12.09.2014
    Status:
    Published

  3. Comparison of UHPLC-DAD and HPLC-DAD methods for separation studies of naratriptan hydrochloride forms differing in structural polymorphism and its impurities

    Authors:
    Zalewski P, Talaczyńska A, Skibiński R, Krause A, Paczkowska M, Starzecka M, Cielecka-Piontek J
    Conference:
    26th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2015) (year: 2015, pages: 134), Publisher: 26th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2015)
    Date:
    conference 5-8.07.2015
    Status:
    Published

  4. Principal component analysis for determination of polymorphic forms of ranitidine hydrochloride

    Authors:
    Mizera M, Lewandowska K, Paczkowska M, Miklaszewski A, Cielecka-Piontek J
    Conference:
    14th Scandinavian Symposium on Chemometrics (year: 2015, pages: 81), Publisher: 14th Scandinavian Symposium on Chemometrics
    Date:
    conference 14-17.06.2015
    Status:
    Published

  5. Development of UHPLC-DAD method for stability, solubility and compatibility studies of losartan potassium forms differing in structural polymorphism

    Authors:
    Cielecka-Piontek J, Talaczyńska A, Zalewski P
    Conference:
    21st International Symposium on Separation Sciences (year: 2015, pages: 150), Publisher: 21st International Symposium on Separation Sciences
    Date:
    conference 30.06-3.07.2015
    Status:
    Published

  6. Zastosowanie metod spektrofotometrycznych w badaniach polimorfizmu strukturalnego benzokainy

    Authors:
    Paczkowska M, Mroczkowska M, Zalewski P, Cielecka-Piontek J
    Conference:
    Nauka i przemysł - metody spektroskopowe w praktyce, nowe wyzwania i możliwości. Lublin 2015 (year: 2015, pages: 95-98), Publisher: Uniwersytet Marii Curie-Skłodowskiej w Lublinie Wydział Chemii
    Date:
    conference 9-11.06.2015
    Status:
    Published

  7. Studies of polymorphs forms of cefuroxym axetyl

    Authors:
    Cielecka-Piontek J, Lewandowska K, Garbacki P, Podborska A, Zalewski P, Jelińska A, Oszczapowicz I
    Conference:
    Drug Analysis 2014 (year: 2014, pages: 236), Publisher: Drug Analysis 2014
    Date:
    conference 22-25.06.2014
    Status:
    Published

  8. Comparative studies of gradient HPLC-DAD and isocratic UHPLC-DAD methods for analysis of sumatriptan succinate

    Authors:
    Cielecka-Piontek J, Paczkowska M, Talaczyńska A, Krause A
    Conference:
    21st International Symposium on Separation Sciences (year: 2015, pages: 151), Publisher: 21st International Symposium on Separation Sciences
    Date:
    conference 30.06-3.07.2015
    Status:
    Published

  9. Analysis of structural polymorphism of sorafenib tosylate by FT-IR and Raman spectroscopy

    Authors:
    Gabriela Wiergowska, Kornelia Lewandowska, Judyta Cielecka-Piontek
    Conference:
    XIVth Internation Conference on Molecular Spectroscopy From molecules to functional materials (year: 2017, pages: 316), Publisher: brak
    Date:
    conference 3-7.09.2017
    Status:
    Published

  10. Spektroskopowe właściwości losartanu potasu w oparciu o eksperymentalne i teoretyczne badania

    Authors:
    Mizera M, Lewandowska K, Talaczyńska A, Zalewski P, Cielecka-Piontek J
    Conference:
    Nowoczesne techniki badawcze stosowane w analizie farmaceutycznej i biomedycznej (year: 2014, pages: brak numeracji stron), Publisher: Wydział Farmaceutyczny Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy
    Date:
    conference 10-12.09.2014
    Status:
    Published

  11. Freeze-drying as an effective method for obtaining amorphous forms of vardenafil hydrochloride

    Authors:
    Gabriela Wiergowska; Przemysław Zalewski; Daria Szymanowska-Powałowska; Andrzej Miklaszewski; Kornelia Lewandowka; Judyta Cielecka-Piontek
    Conference:
    11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (year: 2018, pages: 205), Publisher: ResearchPharm International Excibition for R & D
    Date:
    conference 19-22 marca
    Status:
    Published

  12. The APPLICATION OF HPLC-DAD METHOD FOR AN ASSAY OF SOLUBILITY DIFFERENCES OF SORAFENID POLYMOPHIC FORMS

    Authors:
    Gabriela Wiergowska, Anna Stasiłowicz, Judyta Cielecka-Piontek
    Conference:
    2th International Symposium on Advances in Pharmaceutical Analysis (year: 2018, pages: 81), Publisher: Faculty of Pharmacy, Lille, France
    Date:
    conference 12-13 lipca
    Status:
    Published

  13. Badania efektów oddziaływań hydroksy-propylometylocelulozy z krystalicznymi postaciami wybranych aktywnych substancji farmaceutycznych

    Authors:
    Talaczyńska A, Zalewski P, Szymanowska-Powałowska D, Kozak M, Kubiak B, Cielecka-Piontek J
    Conference:
    BioOrg 2015, I Wielkopolskie Seminarium Chemii Bioorganicznej, Organicznej i Biomateriałów (year: 2015, pages: 25-26), Publisher: BioOrg 2015, I Wielkopolskie Seminarium Chemii Bioorganicznej, Organicznej i Biomateriałów
    Date:
    conference 5.12.2015
    Status:
    Published

  14. The effects of biopolimeres interactions with amorphous form of losartan potassium

    Authors:
    Gabriela Wiergowska, Magdalena Paczowska, Andrzej Miklaszewski, Kornelia Lewandowska, Daria Szymnaowska-Powałowska, Judyta Cielecka-Piontek
    Conference:
    2017 Controlled Release Society Annual Meeting (year: 2017, pages: brak), Publisher: Boston
    Date:
    conference 16-19.07.2017
    Status:
    Published

  15. New approch for old drugs - polymorphic and amorphous forms of active pharmaceutical ingredients

    Authors:
    Gabriela Wiergowska, Maria Starzecka, Kornelia Lewandowska, Andrzej Miklaszewski, Anna Krause, Przemysław Zalewski, Judyta Cielecka-Piontek
    Conference:
    53rd International Conference on Medicinal Chemistry RICT 2017 Drug discovery and selection (year: 2017, pages: 136), Publisher: brak
    Date:
    conference 5-7.07.2017
    Status:
    Published

  16. Studies of crystalline and amorphous forms of losartan potassium during the preformulation phase

    Authors:
    Alicja Talaczyńska, Przemysław Zalewski, Daria Szymanowska-Powałowska, Andrzej Miklaszewski, Kornelia Lewandowska, Judyta Cielecka-Piontek.
    Conference:
    10th World Meeting on Pharmaceutics Biopharmaceutics and Pharmaceutical Technology. Glasgow, United Kingdom, 2016. (year: 2016, pages: 46024), Publisher: www.wordmeeting.org
    Date:
    conference 4-7 IV
    Status:
    Published

  17. Studies of influence of structurally polymorphism APIs on apparent solubility and permeability through parallel artificial membranes

    Authors:
    Alicja Talaczyńska, Magdalena Paczkowska, Daria Szymanowska-Powałowska, Andrzej Miklaszewski, Joanna Gościańska, Przemysław Zalewski, Judyta Cielecka-Piontek
    Conference:
    52nd International Conference on Medicinal Chemistry RICT 2016 Interfacing Chemical Biology and Drug Discovery (year: 2016, pages: 140), Publisher: http://www.ldorganisation.com/produits.php?langue=english&cle_menus=1238916167
    Date:
    conference July 6-8, 2016, Cean, France
    Status:
    Published

  18. Preformulation studies of crystalline forms of ranitidine hydrochloride

    Authors:
    Alicja Talaczyńska, Natalia Gwódź, Jakub Dzitko, Mikołaj Mizera, Andrzej Miklaszewski, Przemysław Zalewski
    Conference:
    10th World Meeting on Pharmaceutics Biopharmaceutics and Pharmaceutical Technology. Glasgow, United Kingdom, 4-7 IV 2016. (year: 2016, pages: 46024), Publisher: www.wordmeeting.org
    Date:
    conference 4-7 IV
    Status:
    Published

Book publications / chapters in book publications (6)

  1. The Application of Vibrational Spectroscopy in Studies of Structural Polymorphism of Drugs

    Authors:
    Przemysław Zalewski, Gabriela Wiergowska, Joanna Goscianska, Kornelia Lewandowska, Judyta Cielecka-Piontek
    Book:
    Recent Advances in Analytical Techniques, 2018, Vol. 2, 173-207 (year: 2018, volume: I, pages: 173-207), Publisher: Bentham
    Status:
    Published

  2. Fizyczne i biologiczne konsekwencje obecności polimorficznych i amorficznych form aktywnych substancji farmaceutycznych

    Authors:
    Judyta Cielecka-Piontek, Magdalena Paczkowska, Gabriela Wiergowska
    Book:
    Nauka i przemysł - metody spektroskopowe w praktyce, nowe wyzwania i możliwości (year: 2017, volume: I, pages: 32-41), Publisher: Lublin UMCS
    Status:
    Published

  3. Zastosowanie metod spektroskopowych w analizie tryptanów

    Authors:
    Cielecka-Piontek J, Talaczyńska A, Paczkowska M, Lewandowska K, Szybowicz M, Mizera M, Krause A, Zalewski P
    Book:
    Nauka i przemysł - metody spektroskopowe w praktyce, nowe wyzwania i możliwości. Lublin 2015 (year: 2015, volume: 1, pages: 78-90), Publisher: Uniwersytet Marii Curie-Skłodowskiej w Lublinie Wydział Chemii
    Status:
    Published

  4. Zastosowanie technik spektroskopowych w potwierdzeniu tożsamości, badaniu rozpuszczalności i dostępności farmaceutycznej wybranych form polimorficznych atorwastatyny

    Authors:
    Paczkowska M, Zalewski P, Mizera M, Lewandowska K, Szybowicz M, Szymanowska-Powałowska D, Cielecka-Piontek J
    Book:
    Nauka i przemysł - metody spektroskopowe w praktyce, nowe wyzwania i możliwości. Lublin 2015 (year: 2015, volume: 1, pages: 99-109), Publisher: Uniwersytet Marii Curie-Skłodowskiej w Lublinie Wydział Chemii
    Status:
    Published

  5. Zastosowanie metod spektrofotometrycznych w badaniu polimorfizmu substancji leczniczych

    Authors:
    Cielecka-Piontek J, Zalewski P, Lewandowska K, Podborska A
    Book:
    Nauka i przemysł - metody spektroskopowe w praktyce, nowe wyzwania i możliwości. T.1. Pr. zbior. pod red. Zbigniewa Hubickiego Lublin 2014 (year: 2014, volume: 1, pages: 18-28), Publisher: Uniwersytet Marii Curie-Skłodowskiej w Lublinie Wydział Chemii
    Status:
    Published

  6. BADANIA TOŻSAMOŚCI I OZNACZANIA CHLOROWODORKU WARDENAFILU WYKAZUJĄCEGO POLIMORFIZM STRUKTURALNY

    Authors:
    A. TALACZYŃSKA, A. MIKLASZEWSKI, B. KUBIAK, K. LEWANDOWSKA, D. SZYMANOWSKA-POWAŁOWSKA, P. ZALEWSKI, J. CIELECKA-PIONTEK
    Book:
    Nauka i przemysł - metody spektroskopowe w praktyce, nowe wyzwania i możliwości (year: 2016, volume: 1, pages: 307-317), Publisher: Uniwersytet Marii Skłodowskiej-Currie
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski