Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The effects of pregnant female diet on the DNA methylation patterns inheritance in the offspring

2013/09/D/NZ2/02006

Keywords:

DNA methylation transcription nutrigenomics rat

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Nowacka-Woszuk 

Number of co-investigators in the project: 5

Call: SONATA 5 - announced on 2013-03-15

Amount awarded: 694 145 PLN

Project start date (Y-m-d): 2014-03-14

Project end date (Y-m-d): 2018-03-13

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komuter persoanlny wraz z wyposażeniem i oprogramowaniem (6 000 PLN)
  2. System detekcji i wizualizacji żeli techniką chemiluminescencji (80 000 PLN)
  3. Termoblok do rekacji PCR (35 000 PLN)
  4. Zestaw klatek do utrzymywania zwierząt (25 000 PLN)
  5. Bioanalizator 2010-Aparat do mikrofluidycznej elektroforezy kwasów nukleinowych i białek.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Prenatal caloric restriction alters lipid metabolism but not hepatic Fasn expression and mathylation profiles in rats.
    Authors:
    Nowacka-Woszuk J., Madeja Z. E., Chmurzynska A.
    Academic press:
    BMC Genetics (rok: 2017, tom: 18 (1), strony: 78), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12863-017-0544-0 - link to the publication
  2. Transgenerational effects of prenatal restricted diet on gene expression and histone modifications in the rat
    Authors:
    Nowacka-Woszuk J., Szczerbal I., Malinowska AM., Chmurzynska A
    Academic press:
    PLOS ONE (rok: 2018, tom: 23;13(2), strony: e0193464), Wydawca: Public Library of Science (PLOS)
    Status:
    Published
    DOI:
    10.1371/journal.pone.0193464 - link to the publication
  3. Hepatic DNA methylation and expression profiles under prenatal restricted diet in three generations of female rat fetuses.
    Authors:
    Nowacka-Woszuk J., Grzemski A., Sliwinska M., Chmurzynska A.
    Academic press:
    Plos One (rok: 2019, tom: 16;14(4), strony: e0215471), Wydawca: Public Library of Science (PLOS)
    Status:
    Published
    DOI:
    10.1371/journal.pone.0215471 - link to the publication
  4. Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model.
    Authors:
    Chmurzynska A, Mlodzik MA, Radziejewska A, Szwengiel A, Malinowska AM, Nowacka-Woszuk J
    Academic press:
    Biochimie (rok: 2018, tom: 152, strony: 181-187), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biochi.2018.07.007 - link to the publication
  5. Nutrition modulates Fto and Irx3 gene transcript levels, but does not alter their DNA methylation profiles in rat white adipose tissues
    Authors:
    Nowacka-Woszuk J., Pruszynska-Oszmalek E., Szydlowski M., Szczerbal I
    Academic press:
    Gene (rok: 2017, tom: 610, strony: 44-48), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.gene.2017.02.002 - link to the publication
  1. Fto and Irx3 transcription and methylation profiles in adipose tissues of rats fed with high-fat and high-protein diets
    Authors:
    Nowacka-Woszuk J., Pruszynska-Oszmalek E., Szydlowski M., Szczerbal I
    Conference:
    35th International Society for Animal Genetics Conference (rok: 2016, ), Wydawca: Journal of Animal Science
    Data:
    konferencja 23.07.16 – 27.07.16
    Status:
    Published
  2. The influence of different diets on transcriptional and methylation profiles of the Fto and Irx3 genes in the rat
    Authors:
    Nowacka-Woszuk J., Pruszyńska-Oszmałek E., Szydłowski M., Szczerbal I.
    Conference:
    V Polski Kongres Genetyki (rok: 2016, ), Wydawca: Polskie Towarzystwo Genetyczne oraz Polskie Towarzystwo Genetyki Człowieka
    Data:
    konferencja 19.06.16 - 22.09.16
    Status:
    Published