Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Inhibitory neurotransmitter GABA in the aging of nervous system

2013/09/B/NZ3/00540

Keywords:

GABA aging plasticity

Descriptors:

  • NZ3_4: Ageing
  • NZ4_10: Neuroimaging and computational neuroscience

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Monika Liguz-Lęcznar 

Number of co-investigators in the project: 6

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 750 000 PLN

Project start date (Y-m-d): 2014-03-03

Project end date (Y-m-d): 2018-09-02

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. zestaw komputerowy (2 szt.) (8 000 PLN)
  2. Płuczka mikropłytek (31 000 PLN)
  3. Zestaw do analizy densytometrycznej (50 000 PLN)
  4. Kriostat laboratoryjny (100 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (8)
  1. Osłabienie sprawnoœci poznawczej w starzeniu. Przyczyny i mechanizmy neurobiologiczne.
    Authors:
    Monika Liguz-Lęcznar
    Academic press:
    Gerontologia Polska (rok: 2014, tom: 3, strony: 166-171), Wydawca: Wydawca: Polskie Towarzystwo Gerontologiczne; Wydawnictwo Akademia Medycyny
    Status:
    Published
  2. Somatostatin and Somatostatin-Containing Neurons in Shaping Neuronal Activity and Plasticity.
    Authors:
    Liguz-Lecznar M, Urban-Ciecko J, Kossut M.
    Academic press:
    Frontiers in Neural Circuits (rok: 2016, tom: 10, strony: article 48, pages 1-15), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fncir.2016.00048 - link to the publication
  3. Glutamate, GABA and presynaptic markers involved in neurotransmission are differently affected by age in distinct mouse brain regions.
    Authors:
    Aleksandra Rozycka, Agata Charzynska, Zuzanna Misiewicz, Tomasz Stepniewski, Alicja Sobolewska, Malgorzata Kossut,d, Monika Liguz-Lecznar
    Academic press:
    ACS Chemical Neuroscience (rok: 2019, tom: 10(11), strony: 4449-4461), Wydawca: ACS Publications (Stany Zjednoczone)
    Status:
    Published
    DOI:
    10.1021/acschemneuro.9b00220 - link to the publication
  4. The space where aging acts:focus onthe GABAergic synapse
    Authors:
    Rozycka A, Liguz-Lecznar M.
    Academic press:
    Aging Cell. (rok: 2017, tom: 16(4), strony: 634–643), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1111/acel.12605. - link to the publication
  1. Age dependent changes in the number of somatostatin-containing interneurons
    Authors:
    Rozycka A., Zakrzewska R., Kossut M., Liguz-Lecznar M.
    Conference:
    10th FENS Forum of Neuroscience 2016 (rok: 2016, ), Wydawca: FENS
    Data:
    konferencja 2-6 July
    Status:
    Published
  2. - Comparative analysis of age-related changes of amino acids involved in glutamate and GABA levels regulation.
    Authors:
    Aleksandra Rozycka, Alicja Sobolewska, Renata Zakrzewska, Malgorzata Kossut,Monika Liguz-Lecznar
    Conference:
    11th FENS Forum of Neuroscience 2018 (rok: 2018, ), Wydawca: FENS
    Data:
    konferencja 7.07-11.07
    Status:
    Published
  3. Age-related plasticity impairments-presynaptic mechanisms.
    Authors:
    M. Liguz-Lęcznar
    Conference:
    12th International Congres of the Polish Neuroscience Society (rok: 2015, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 06.09-08.09.
    Status:
    Published
  4. Comparative aspects of presynaptic aging of mouse brain.
    Authors:
    Monika Liguz-Lecznar; Aleksandra Kaliszewska; Zuzanna Misiewicz; Tomasz Stepniewski; Renata Zakrzewska; Malgorzata Kossut
    Conference:
    IBRO 9th World Congress (rok: 2015, ), Wydawca: IBRO
    Data:
    konferencja 07.07-11.07
    Status:
    Published
  5. Presynaptic proteins in aging mouse brain
    Authors:
    A. Rozycka, R. Zakrzewska, M. Kossut, M. Liguz-lecznar
    Conference:
    SfN's 47th annual meeting, Neuroscience (rok: 2017, ), Wydawca: Society for Neuroscience-Neuroscience 2017
    Data:
    konferencja 11-15.11
    Status:
    Published
  6. Neurobiologia Pamięci w starzeniu
    Authors:
    Monika Liguz-Lęcznar
    Conference:
    Kobieta i Mężczyzna. Zdrowe starzenie. (rok: 2014, ), Wydawca: Organizatorzy kongresu
    Data:
    konferencja 10.10-11.10
    Status:
    Published
  7. Presynaptic aging of mouse brain
    Authors:
    Liguz-Lecznar M., Kaliszewska A., Stepniewski T., Zakrzewska R., Kossut M.
    Conference:
    10th FENS Forum of Neuroscience 2016 (rok: 2016, ), Wydawca: FENS
    Data:
    konferencja 2-6 July
    Status:
    Published
  8. Gabaergic system in aging. Focus on somatostatin containing interneurons.
    Authors:
    Aleksandra Różycka, Renata Zakrzewska, Monika Liguz Lęcznar
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 28-31.09.
    Status:
    Published