Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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A novel mechanism of severe anemia mediated by a mutant form of Erythroid Kruppel-like Factor (EKLF/KLF1)

2013/09/B/NZ1/01879

Keywords:

erythropoiesis red blood cells transcription factor EKLF anemia mutations

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ5_2: Etiology of animal diseases
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Mirosława Siatecka 

Number of co-investigators in the project: 3

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 1 457 547 PLN

Project start date (Y-m-d): 2014-02-12

Project end date (Y-m-d): 2019-02-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  1. "Severe anemia caused by dominant mutations in Krüppel-like factor 1 (KLF1)"
    Authors:
    Klaudia Kulczyńska, James J. Bieker, Mirosława Siatecka,
    Academic press:
    Mutation Research – Reviews in Mutation Research (rok: 2020, tom: 786:108336, strony: 45300), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrrev.2020.108336 - link to the publication
  2. A regulatory function of long non-coding RNAs in red blood cell development
    Authors:
    Klaudia Kulczyńska, Mirosława Siatecka
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: 675-680), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2016_1351 - link to the publication
  3. A Krüppel-like factor 1 (KLF1) Mutation Associated with Severe Congenital Dyserythropoietic Anemia Alters Its DNA-Binding Specificity
    Authors:
    K Kulczyńska, JJ Bieker and M Siatecka
    Academic press:
    Molecular and Cellular Biology (rok: 2020, tom: 12;40(5), strony: e00444-19.), Wydawca: The American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/MCB.00444-19 - link to the publication
  4. Neomorphic effects of the neonatal anemia (Nan-Eklf ) mutation contribute to deficits throughout development
    Authors:
    Antanas Planutis, Li Xue, Cecelia D. Trainor, Mohan Dangeti, Kevin Gillinde, Miroslawa Siatecka, Danitza Nebor, Luanne L. Peters, Andrew C. Perkins, James J. Bieker
    Academic press:
    Development (rok: 2017, tom: 144, strony: 430-440), Wydawca: Published by The Company of Biologists Ltd
    Status:
    Published
    DOI:
    10.1242/dev.145656 - link to the publication
  5. Transcriptional Activity of Erythroid Kruppel-like Factor (EKLF/KLF1) Modulated by Protein Inhibitor of Activated STAT3 (PIAS3)
    Authors:
    Miroslawa Siatecka,Shefali Soni, Antanas Planutis, James J. Bieker
    Academic press:
    The Journal of Biological Chemistry (rok: 2015, tom: 290 (15), strony: 9929-40), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M114.610246 - link to the publication

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