A novel mechanism of severe anemia mediated by a mutant form of Erythroid Kruppel-like Factor (EKLF/KLF1)
2013/09/B/NZ1/01879
Keywords
Descriptors
- NZ2_1: Genetyka molekularna
- NZ5_2: Etiologia chorób zwierząt
- NZ1_1: Biologia molekularna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
OPUS 5 – announced on 2013-03-15
- Amount awarded
- 1 457 547 PLN
- Project start date
- 2014-02-12
- Project end date
- 2019-02-11
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (5)
-
Transcriptional Activity of Erythroid Kruppel-like Factor (EKLF/KLF1) Modulated by Protein Inhibitor of Activated STAT3 (PIAS3)
- Authors:
- Miroslawa Siatecka,Shefali Soni, Antanas Planutis, James J. Bieker
- Academic press:
- The Journal of Biological Chemistry (year: 2015, volume: 290 (15), pages: 9929-40), Publisher: American Society for Biochemistry and Molecular Biology
- Status:
- Published
- DOI:
- 10.1074/jbc.M114.610246 – link to the publication
-
A regulatory function of long non-coding RNAs in red blood cell development
- Authors:
- Klaudia Kulczyńska, Mirosława Siatecka
- Academic press:
- Acta Biochimica Polonica (year: 2016, volume: 63, pages: 675-680), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
- Status:
- Published
- DOI:
- 10.18388/abp.2016_1351 – link to the publication
-
Neomorphic effects of the neonatal anemia (Nan-Eklf ) mutation contribute to deficits throughout development
- Authors:
- Antanas Planutis, Li Xue, Cecelia D. Trainor, Mohan Dangeti, Kevin Gillinde, Miroslawa Siatecka, Danitza Nebor, Luanne L. Peters, Andrew C. Perkins, James J. Bieker
- Academic press:
- Development (year: 2017, volume: 144, pages: 430-440), Publisher: Published by The Company of Biologists Ltd
- Status:
- Published
- DOI:
- 10.1242/dev.145656 – link to the publication
-
Severe anemia caused by dominant mutations in Krüppel-like factor 1 (KLF1)
- Authors:
- Klaudia Kulczyńska, James J. Bieker, Mirosława Siatecka,
- Academic press:
- Mutation Research – Reviews in Mutation Research (year: 2020, volume: 786:108336, pages: 46031), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.mrrev.2020.108336 – link to the publication
-
A Krüppel-like factor 1 (KLF1) Mutation Associated with Severe Congenital Dyserythropoietic Anemia Alters Its DNA-Binding Specificity
- Authors:
- K Kulczyńska, JJ Bieker and M Siatecka
- Academic press:
- Molecular and Cellular Biology (year: 2020, volume: 12;40(5), pages: e00444-19.), Publisher: The American Society for Microbiology
- Status:
- Published
- DOI:
- 10.1128/MCB.00444-19 – link to the publication