Cytotoksyczne koniugaty, oparte o białko affibody i glikol polietylenowy, celujące w komórki nowotworowe, które posiadają na powierzchni receptor HER2
2013/08/S/NZ1/00845
Descriptors
- NZ1_9: Biotechnologia
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Wrocławski, Wydział Biotechnologii
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
dr Alicja Maria Sochaj-Gregorczyk
Number of co-investigators in the project: 2
Call
FUGA 2 – announced on 2012-12-15
- Amount awarded
- 612 000 PLN
- Project start date
- 2013-10-01
- Project end date
- 2016-09-30
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (4)
-
Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1
- Authors:
- Sochaj-Gregorczyk AM, Ludzia P, Kozdrowska E, Jakimowicz P, Sokolowska-Wedzina A, Otlewski J.
- Academic press:
- International Journal of Molecular Sciences (year: 2017, volume: 18(8), pages: E1688), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms18081688 – link to the publication
-
A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells.
- Authors:
- Serwotka-Suszczak AM, Sochaj-Gregorczyk AM, Pieczykolan J, Krowarsch D, Jelen F, Otlewski J.
- Academic press:
- International Journal of Molecular Sciences (year: 2017, volume: 18(2), pages: E401), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms18020401 – link to the publication
-
A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines.
- Authors:
- Alicja M. Sochaj-Gregorczyk, Anna M. Serwotka-Suszczak, Jacek Otlewski
- Academic press:
- Journal of Immunotherapy (year: 2016, volume: 39, pages: 223-232), Publisher: Wolters Kluwer
- Status:
- Published
- DOI:
- 10.1097/CJI.0000000000000125 – link to the publication
-
Current methods for the synthesis of homogeneous antibody–drug conjugates
- Authors:
- Alicja M. Sochaj, Karolina W. Świderska, Jacek Otlewski
- Academic press:
- Biotechnology Advances (year: 2015, volume: 33, pages: 775-784), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.biotechadv.2015.05.001 – link to the publication
Articles in post-conference publications (1)
-
A novel affibody-auristatin E conjugate that targets HER2-positive cancer cell lines
- Authors:
- Alicja M. Sochaj-Gregorczyk, Anna Serwotka-Suszczak and Jacek Otlewski
- Conference:
- 2 nd BIO 2016 Congress Expanding beyond the limits (year: 2016, pages: 120 (O15.3)), Publisher: Acta Biochimica Polonica
- Date:
- conference 13-16 wrzesień 2016
- Status:
- Published
- DOI:
- link to the publication