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Information on the principal investigator and host institution

Information of the project and the call

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Cytotoksyczne koniugaty, oparte o białko affibody i glikol polietylenowy, celujące w komórki nowotworowe, które posiadają na powierzchni receptor HER2

2013/08/S/NZ1/00845

Keywords:

Descriptors:

  • NZ1_9: Biotechnology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Alicja Sochaj-Gregorczyk 

Number of co-investigators in the project: 2

Call: FUGA 2 - announced on 2012-12-15

Amount awarded: 612 000 PLN

Project start date (Y-m-d): 2013-10-01

Project end date (Y-m-d): 2016-09-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. Current methods for the synthesis of homogeneous antibody–drug conjugates
    Authors:
    Alicja M. Sochaj, Karolina W. Świderska, Jacek Otlewski
    Academic press:
    Biotechnology Advances (rok: 2015, tom: 33, strony: 775-784), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biotechadv.2015.05.001 - link to the publication
  2. Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1
    Authors:
    Sochaj-Gregorczyk AM, Ludzia P, Kozdrowska E, Jakimowicz P, Sokolowska-Wedzina A, Otlewski J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2017, tom: 18(8), strony: E1688), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms18081688 - link to the publication
  3. A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells.
    Authors:
    Serwotka-Suszczak AM, Sochaj-Gregorczyk AM, Pieczykolan J, Krowarsch D, Jelen F, Otlewski J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2017, tom: 18(2), strony: E401), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms18020401 - link to the publication
  4. A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines.
    Authors:
    Alicja M. Sochaj-Gregorczyk, Anna M. Serwotka-Suszczak, Jacek Otlewski
    Academic press:
    Journal of Immunotherapy (rok: 2016, tom: 39, strony: 223-232), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/CJI.0000000000000125 - link to the publication
  1. A novel affibody-auristatin E conjugate that targets HER2-positive cancer cell lines
    Authors:
    Alicja M. Sochaj-Gregorczyk, Anna Serwotka-Suszczak and Jacek Otlewski
    Conference:
    2 nd BIO 2016 Congress "Expanding beyond the limits" (rok: 2016, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 13-16 wrzesień 2016
    Status:
    Published
    DOI:
    link to the publication

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