Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Lipid antigens as a target for autoimmune attack in multiple sclerosis.

2013/08/M/NZ3/01040

Keywords:

multiple sclerosis myelin lipid antigens ceramide

Descriptors:

  • NZ3_3: Apoptosis
  • NZ3_6: Cell neurobiology
  • NZ3_14: Other related subjects

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Maria Podbielska 

Number of co-investigators in the project: 11

Call: HARMONIA 4 - announced on 2012-12-15

Amount awarded: 900 764 PLN

Project start date (Y-m-d): 2013-09-23

Project end date (Y-m-d): 2018-09-22

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (2)
  • Book publications / chapters in book publications (1)
  1. Autoimmunity in multiple sclerosis: role of sphingolipids, invariant NKT cells and other immune elements in control of inflammation and neurodegeneration
    Authors:
    M. Podbielska, J. O'Keeffe, E. L. Hogan
    Academic press:
    Journal of the Neurological Sciences (rok: 2018, tom: 385, strony: 198-214), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jns.2017.12.022 - link to the publication
  2. Ceramide is Implicated in Humoral Peripheral and Intrathecal Autoimmune Response in MS Patients
    Authors:
    Maria Podbielska, Jozefa Macala, Anna Jakubiak-Augustyn, Zdzislaw M. Szulc, Wojciech Fortuna, Slawomir Budrewicz, Ewa Jaskiewicz, Malgorzata Bilinska, Edward L. Hogan, Anna Pokryszko-Dragan
    Academic press:
    Multiple Sclerosis and Related Disorders (rok: 2023, tom: 71: 104565, strony: 45301), Wydawca: ELSEVIER SCI LTD
    Status:
    Published
    DOI:
    10.1016/j.msard.2023.104565 - link to the publication
  3. Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line
    Authors:
    Maria Podbielska, Zdzisław M. Szulc, Ewa Kurowska, Edward L. Hogan, Jacek Bielawski, Alicja Bielawska, Narayan R. Bhat
    Academic press:
    Journal of Lipid Research (rok: 2016, tom: 57, strony: 2028–2039), Wydawca: The American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1194/jlr.M070664 - link to the publication
  4. Sphingolipid Players in Multiple Sclerosis: Their Influence on the Initiation and Course of the Disease
    Authors:
    Maria Podbielska, Toshio Ariga, Anna Pokryszko-Dragan
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(10): 5330, strony: 45314), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23105330 - link to the publication
  5. Distinctive sphingolipid patterns in chronic multiple sclerosis lesions
    Authors:
    Maria Podbielska, Zdzislaw M. Szulc, Toshio Ariga, Anna Pokryszko-Dragan, Wojciech Fortuna, Malgorzata Bilinska, Ryszard Podemski, Ewa Jaskiewicz, Ewa Kurowska, Robert K. Yu, Edward L. Hogan
    Academic press:
    Journal of Lipid Research (rok: 2020, tom: 61, strony: 1464-1479), Wydawca: The American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1194/jlr.RA120001022 - link to the publication
  6. New insights into multiple sclerosis mechanisms: lipids on the track to control inflammation and neurodegeneration
    Authors:
    Maria Podbielska, Joan O'Keeffe, Anna Pokryszko-Dragan
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(14): 7319, strony: 45320), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22147319 - link to the publication
  1. Ceramide-enriched exosomes as a potential mediator of cytokine-induced cell death signaling in a human oligodendroglial cell line
    Authors:
    Podbielska M., Szulc Z.M., Kurowska E., Hogan E.L., Bielawski J., Bielawska A., Bhat N.R.
    Conference:
    50th Southeastern Regional Lipid Conference (rok: 2015, ), Wydawca: Malcolm Fifer
    Data:
    konferencja 11-13 listopada
    Status:
    Published
  2. Targeted sphingolipidomics: monitoring key sphingolipids in chronic multiple sclerosis lesions
    Authors:
    Szulc Z.M., Bielawski J., Kurowska E., Podemski R., Bilinska M., Pokryszko-Dragan A., Fortuna W., Jaskiewicz E., Bielawska A., Hogan E.L. and Podbielska M.
    Conference:
    51th Southeastern Regional Lipid Conference (rok: 2016, ), Wydawca: Frontiers in Lipid Technology
    Data:
    konferencja 09-11 listopada
    Status:
    Published
  1. New pathomechanisms related to autoimmune demyelination in multiple sclerosis.
    Authors:
    M. Podbielska
    Book:
    Annual Report 2017 (rok: 2017, tom: nie dotyczy, strony: 64-65), Wydawca: Communications and Science Promotion Department Polish Academy of Sciences
    Status:
    Published

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