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Information on the principal investigator and host institution

Information of the project and the call

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Studies on antiplatelet and antithrombotic activity of CO-relasing molecules (CO-RM)

2013/08/M/NZ7/01034

Keywords:

Endothelium platelets thrombosis Pharmacology carbon monoxide

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Stefan Chłopicki 

Number of co-investigators in the project: 11

Call: HARMONIA 4 - announced on 2012-12-15

Amount awarded: 1 222 182 PLN

Project start date (Y-m-d): 2013-09-23

Project end date (Y-m-d): 2016-12-22

Project duration:: 39 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (3)
  1. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels.
    Authors:
    Kaczara P, Motterlini R, Rosen GM, Augustynek B, Bednarczyk P, Szewczyk A, Foresti R, Chlopicki S.
    Academic press:
    Biochim Biophys Acta Bioenerg (rok: 2015, tom: 1847(10), strony: 1297-309), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2015.07.004 - link to the publication
  2. Modified Biovectors for the Tuneable Activation of Anti-platelet Carbon Monoxide
    Authors:
    Prietoa L, Rossierc J, Derszniak K, Dybasb J, Oetterlia RM, Kottelatc E, Chlopicki S, Zeldera F, Zobic F
    Academic press:
    Chemical Communications (rok: 2017, tom: 53, strony: 6840-6843), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7cc03642f - link to the publication
  3. CORM-401 induces calciumsignalling, NO increase and activation of pentose phosphate pathway in endothelial cells
    Authors:
    Kaczara P., Proniewski B., Lovejoy Ch., Kus K., Motterlini R., Abramov A.Y., Chlopicki S.
    Academic press:
    The FEBS Journal (rok: 2018, tom: 285, strony: 1346-1358), Wydawca: Federation of European Biochemical Societies
    Status:
    Published
    DOI:
    10.1111/febs.14411 - link to the publication
  4. Carbon monoxide shifts energetic metabolism from glycolysis to oxidative phosphorylation in endothelial cells
    Authors:
    Kaczara P, Motterlini R, Kus K, Zakrzewska A, Abramov AY, Chlopicki S
    Academic press:
    FEBS Letters (rok: 2016, tom: 590, strony: 3469–3480), Wydawca: Federation of European Biochemical Societies
    Status:
    Published
    DOI:
    10.1002/1873-3468.12434 - link to the publication
  1. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: a role for mitoBKCa channels
    Authors:
    P. Kaczara, R. Motterlini, G. M. Rosen, B. Augustynek, P.
    Conference:
    Metabolism in Cancer and Stromal Cells (rok: 2015, ), Wydawca: VIB Conference Series
    Data:
    konferencja 8-10 wrzesień 2015
    Status:
    Published
  2. Effects of carbon monoxide released by CORM-401 on oxidative phosphorylation and glycolysis in endothelial cells
    Authors:
    P. Kaczara, R. Foresti, R. Motterlini, S. Chłopicki
    Conference:
    5th World Congress on Targeting Mitochondria (rok: 2014, ), Wydawca: World Mitochondria Society
    Data:
    konferencja 29-31.10.2014
    Status:
    Published
  3. Carbon monoxide regulates endothelial cells bioenergetics
    Authors:
    Kaczara P., Motterlini R., Zakrzewska A., Abramov A.Y., Chłopicki S.
    Conference:
    19 th European Bioenergetics Conference (rok: 2016, ), Wydawca: EBEC 2016
    Data:
    konferencja 02-07.07.2016
    Status:
    Published

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