Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Mitochondrial stress; dynamics of mitochondria relevance to retrograde signaling in fibroblasts derived from patients with diagnosed neurodegenerative diseases

2013/08/M/NZ3/00707

Keywords:

mitochondrial dynamics,mitochondrial stress mitochondrial retrograde signaling biogenesis neurodegeneration

Descriptors:

  • NZ1_2: Biochemistry
  • NZ3_7: Signal transduction
  • NZ3_6: Cell neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Szczepanowska 

Number of co-investigators in the project: 9

Call: HARMONIA 4 - announced on 2012-12-15

Amount awarded: 750 000 PLN

Project start date (Y-m-d): 2013-09-17

Project end date (Y-m-d): 2017-06-16

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (4)
  1. Selenite activates the ATM kinase-dependent DNA repair pathway in human osteosarcoma cells with mitochondrial dysfunction.
    Authors:
    Wojewoda M, Walczak J, Duszynski J, Szczepanowska J.
    Academic press:
    Biochemical Pharmacology (rok: 2015, tom: 93, strony: 170-176), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2015.03.016. - link to the publication
  2. Mechanizmy transportu i dystrybucji mitochondriów w komórce
    Authors:
    Karolina Drabik, Dominika Malińska, Jerzy Duszyński and Joanna Szczepanowska
    Academic press:
    Postępy Biochemii (rok: 2016, tom: 62, strony: 182-188), Wydawca: PTBioch
    Status:
    Published
  3. Zaburzenia dynamiki i dystrybucji mitochondriów w komórkach w stwardnieniu zanikowym bocznym (ALS).
    Authors:
    Walczak J, Szczepanowska J
    Academic press:
    Postępy Biochemii (rok: 2015, tom: 61, strony: 183-190), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
  4. Zmiany dynamiki mitochondriów w odpowiedzi na stres mitochondrialny w modelach sporadycznej formy Choroby Parkinsona
    Authors:
    Małgorzata Partyka, Jerzy Duszyński and Joanna Szczepanowska
    Academic press:
    Postępy Biochemii (rok: 2016, tom: 62, strony: 173-181), Wydawca: PtBioch
    Status:
    Published
  5. Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics
    Authors:
    Walczak J, Dębska-Vielhaber G, Vielhaber S, Szymański J, Charzyńska A, Duszyński J, Szczepanowska J
    Academic press:
    FASEB J (rok: 2019, tom: 33(3), strony: 4388-4403), Wydawca: FEDERATION AMER SOC EXP BIOL
    Status:
    Published
    DOI:
    10.1096/fj.201801843R - link to the publication
  6. Implications of mitochondrial network organization in mitochondrial stress signalling in NARP cybrid and Rho0 cells
    Authors:
    Jarosław Walczak, Małgorzata Partyka, Jerzy Duszyński, Joanna Szczepanowska
    Academic press:
    Scientific Reports (rok: 2017, tom: 7(1), strony: 45305), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-017-14964-y - link to the publication
  7. Quantifying ROS levels using CM-H2DCFDA and HyPer
    Authors:
    Oparka M, Walczak J, Malinska D, Lisanne M.P.E. van Oppen, Szczepanowska J, W J.H. Koopman and M R. Wieckowski
    Academic press:
    Methods (rok: 2016, tom: 16, strony: 30172-30174), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymeth.2016.06.008 - link to the publication
  1. Distribution and trafficking of mitochondria in fibroblasts derived from patients diagnosed with sporadic form of Alzheimer's and Parkinson's diseases
    Authors:
    Drabik K., Dębska-Vielhaber G., Vielhaber S., Duszyński J., Malińska D., Szczepanowska J
    Conference:
    2nd Congress BIO "Expanding beyond the limits (rok: 2016, ), Wydawca: Acta Biochimica Polonika
    Data:
    konferencja 13-16 wrzesien
    Status:
    Published
  2. Mitochondrial distribution and trafficking in primary fibroblasts derived from patients diagnosed with sporadic form of Alzheimer's and Parkinson's diseases
    Authors:
    Drabik K., Dębska-Vielhaber G., Vielhaber S., Duszyński J., Malińska D., Szczepanowska J
    Conference:
    19th EBEC – European Bioenergetics Conference (rok: 2016, ), Wydawca: BBA-bioenergetics
    Data:
    konferencja 2-7 lipca
    Status:
    Published
  3. Mitochondrial calcium uptake, structure and distibution within the primary fibroblast derived from patients diagnosed with sporadic form of Alzheimer's disease
    Authors:
    Drabik K, Malinska D, Debska-Vielhaber G, Vielhaber S, Duszynski J,Szczepanowska J
    Conference:
    42nd FEBS Congress (rok: 2017, ), Wydawca: The FEBS Journal
    Data:
    konferencja 10-14 09.2017
    Status:
    Published
  4. Mitochondrial stress response in fibroblasts derived from patients diagnosed with familial and sporadic form of ALS
    Authors:
    Jarosław Walczak, Grażyna Dębska–Vielhaber, Stefan Vielhaber, Jerzy Duszyński, Joanna Szczepanowska
    Conference:
    19th EBEC - European Bioenergetics Conference (rok: 2016, ), Wydawca: BBA-Bioenergetics
    Data:
    konferencja 2-7 lipca
    Status:
    Published