Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The dual role of the blue light - an interdisciplinary study on effects of the short wavelength visible light on circadian regulation, neural aspects of cognitive and effective functioning, and on the light contribution to degeneration and pathologies of retina

2013/08/W/NZ3/00700

Keywords:

blue light functional magnetic resonance imaging intraocular lenses circadian rhythms cognitive functioning affective functioning biological clock electrophysiology neuronal activity suprachiasmatic nuclei intergeniculate leaflet olivary pretectal nucleus rats melanopsin phototoxicity photoreactivity reactive oxygen species (ROS) antioxidants RGC-5 HEK293 retinal ganglion cells electron paramagnetic resonance (EPR) fluorescence microscopy

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ1_3: Biophysics
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tadeusz Sarna 

Number of co-investigators in the project: 25

Call: SYMFONIA 1

Amount awarded: 6 998 955 PLN

Project start date (Y-m-d): 2013-12-09

Project end date (Y-m-d): 2020-12-08

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Laser EKSPLA NT242 ze zintegrowanym OPO (500 000 PLN)
  2. Wirówka laboratoryjna z chłodzeniem (20 902 PLN)
  3. Odwrócony mikroskop optyczny umożliwiający jednoczesne pomiary optycznie z żywych komórek z pomiarami mikroskopii sił atomowych.
  4. PhysiolTel Telemetry system for EEG, EMG, Temperature & Activity (180 000 PLN)
  5. Detektor wysokorozdzielczy Airyscan 2 (79 999 PLN)
  6. Stół antywibracyjny do rejestracji macierzami wieloelektrodowymi (30 000 PLN)
  7. Zestaw komputerowy (z dwoma monitorami) o dużej mocy obliczeniowej do rejestracji danych (2 szt.) (14 000 PLN)
  8. Zestaw komputerowy do analizy danych rezonansowych (8 000 PLN)
  9. Zestaw komputerowy o dużej mocy obliczeniowej do analizy danych wraz z dyskami do archiwizacji danych (2 szt.) (16 000 PLN)
  10. Enfis Quattro Light Engine (20 000 PLN)
  11. Fluorotron (250 000 PLN)
  12. Kompletny stół optyczny z blatem 1HT15-25-30 oraz wspornikami 1TS065-18-06-AR (20 000 PLN)
  13. Mikroskop fluorescencyjny LEICA DMI6000 B with Bottom Port with IMC (500 000 PLN)
  14. 32-kanałowy OmniPlex Data Acquisition System do rejestracji zewnątrzkomórkowej aktywności neuronalnej in vivo firmy PLEXON (macierze wieloelektrodowe) (190 000 PLN)
  15. Aktigtafy (6 sztuk) (6 szt.) (20 010 PLN)
  16. Aparat sterotaktyczny, manipulatory sterotaktyczne, termostator (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  1. Brain networks involved in place recognition based on personal and spatial semantics
    Authors:
    Beldzik E, Domagalik A, Fafrowicz M, Oginska H, Marek T.
    Academic press:
    BEHAVIOURAL BRAIN RESEARCH (rok: 2020, tom: 398, strony: 11689), Wydawca: ELSEVIER RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
    Status:
    Published
    DOI:
    10.1016/j.bbr.2020.112976. - link to the publication
  2. In vitro phototoxicity of rhodopsin photobleaching products in the retinal pigment epithelium (RPE).
    Authors:
    Olchawa M, Krzysztynska-Kuleta O, Duda M, Pawlak A, Pabisz P, Czuba-Pelech B, Sarna T
    Academic press:
    FREE RADICAL RESEARCH (rok: 2019, tom: 53, strony: 456-471), Wydawca: TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
    Status:
    Published
    DOI:
    10.1080/10715762.2019.1603377 - link to the publication
  3. Melanopsin: From a small molecule to brain functions.
    Authors:
    Duda M, Domagalik A, Orlowska-Feuer P, Krzysztynska-Kuleta O, Beldzik E, Smyk MK, Stachurska A, Oginska H, Jeczmien-Lazur JS, Fafrowicz M, Marek T, Lewandowski MH, Sarna T.
    Academic press:
    Neurosce and Biobehavioral Reviews (rok: 2020, tom: 113, strony: 190-203), Wydawca: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
    Status:
    Published
    DOI:
    10.1016/j.neubiorev.2020.03.012. - link to the publication
  4. The Effect of Antioxidants on Photoreactivity and Phototoxic Potential of RPE Melanolipofuscin Granules from Human Donors of Different Age
    Authors:
    Olchawa MM, Szewczyk GM, Zadlo AC, Sarna MW, Wnuk D, Sarna TJ.
    Academic press:
    Antioxidants (rok: 2020, tom: 9(11):1044, strony: 45313), Wydawca: MDPI ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/antiox9111044 - link to the publication
  5. The influence of intraocular lens implantation and alterations in blue light transmittance level on the brain functional network architecture reorganization in cataract patients.
    Authors:
    Sobczak A., Bohaterewicz B.,Fafrowicz M., Domagalik-Pittner A., Beldzik E.,Oginska H., Golonka N., Rekas M., Bronicki D.,Romanowska-Dixon B., Bolsega-Pacud J., Karwowski W., Farahani F., Marek T.
    Academic press:
    Brain Sciences (rok: 2021, tom: 11/1400, strony: 45303), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/brainsci11111400 - link to the publication
  6. Modulation of Spontaneous and Light-Induced Activity in the Rat Dorsal Lateral Geniculate Nucleus by General Brain State Alterations under Urethane Anesthesia.
    Authors:
    Jeczmien-Lazur JS, Orlowska-Feuer P, Smyk MK, Lewandowski MH.
    Academic press:
    NEUROSCIENCE (rok: 2019, tom: 413, strony: 279-293), Wydawca: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2019.06.017 - link to the publication
  7. Melanopsin Signaling Pathway in HEK293 Cell Line with Stable Expression of Human Melanopsin: Possible Participation of Phospholipase C beta 4 and Diacylglycerol
    Authors:
    Olga I. Krzysztynska-Kuleta, Magdalena M. Olchawa, Tadeusz J. Sarna
    Academic press:
    Photochemistry and Photobiology (rok: 2021, tom: 97, strony: 1136-1144), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/php.13453 - link to the publication
  8. The contribution of inner and outer retinal photoreceptors to infra-slow oscillations in the rat olivary pretectal nucleus.
    Authors:
    Orlowska-Feuer P, Allen AE, Storchi R, Szkudlarek HJ, Lewandowski MH
    Academic press:
    European Journal of Neuroscience (rok: 2016, tom: 43, strony: 823-833), Wydawca: European Neuroscience Association, Wiley
    Status:
    Published
    DOI:
    10.1111/ejn.13184 - link to the publication
  9. Brain Functional Network Architecture Reorganization and Alterations of Positive and Negative Affect, Experiencing Pleasure and Daytime Sleepiness in Cataract Patients after Intraocular Lenses Implantation
    Authors:
    Anna Maria Sobczak, Bartosz Bohaterewicz, Magdalena Fafrowicz, Aleksandra Zyrkowska, Natalia Golonka, Aleksandra Domagalik, Ewa Beldzik, Halszka Oginska, Marek Rekas, Dominik Bronicki, Bozena Romanowska-Dixon, Joanna Bolsega-Pacud, Waldemar Karwowski, Farzad Farahani, Tadeusz Marek
    Academic press:
    Brain Sciences (rok: 2021, tom: 11/1275, strony: 45304), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/brainsci11101275 - link to the publication
  10. Funkcjonowanie emocjonalne w warunkach przedłużonej blokady niebieskiego światła
    Authors:
    M. Król, H.Ogińska, A. Domagalik, J. Janik, T. Marek
    Academic press:
    Czasopismo Psychologiczne (rok: 2017, tom: 23, strony: 337-344), Wydawca: Stowarzyszenie Psychologia i Architektura
    Status:
    Published
    DOI:
    10.14691/CPPJ.23.2.337 - link to the publication
  11. Long-Term Reduction of Short-Wavelength Light Affects Sustained Attention and Visuospatial Working Memory With No Evidence for a Change in Circadian Rhythmicity
    Authors:
    Domagalik A, Oginska H, Beldzik E, Fafrowicz M, Pokrywka M, Chaniecki P, Rekas M, Marek T.
    Academic press:
    Frontiers in Neuroscience (rok: 2020, tom: 1,0375, strony: 45304), Wydawca: FRONTIERS MEDIA SA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015, SWITZERLAND
    Status:
    Published
    DOI:
    10.3389/fnins.2020.00654. - link to the publication
  12. Neuronal Responses to Short Wavelength Light Deficiency in the Rat Subcortical Visual System
    Authors:
    Orlowska-Feuer P, Smyk M K, Alwani A, Lewandowski M H
    Academic press:
    Frontiers in Neuroscience (rok: 2021, tom: 14, strony: 45308), Wydawca: FRONTIERS MEDIA SA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015, SWITZERLAND
    Status:
    Published
    DOI:
    10.3389/fnins.2020.615181 - link to the publication
  13. Quercetin protects ARPE-19 cells against photic stress mediated by the products of rhodopsin photobleaching
    Authors:
    Olchawa MM, Krzysztynska-Kuleta OI, Mokrzynski KT, Sarna PM, Sarna TJ.
    Academic press:
    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (rok: 2020, tom: 19(8), strony: 1022-1034), Wydawca: ROYAL SOC CHEMISTRY THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
    Status:
    Published
    DOI:
    10.1039/d0pp00165a - link to the publication
  14. Regulation of Melanopsin Signaling: Key Interactions of the Nonvisual Photopigment
    Authors:
    Stachurska Anna, Sarna Tadeusz
    Academic press:
    PHOTOCHEMISTRY AND PHOTOBIOLOGY (rok: 2019, tom: 95, strony: 83-94), Wydawca: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Status:
    Published
    DOI:
    10.1111/php.12995. - link to the publication
  15. The effect of aging and antioxidants on photoreactivity and phototoxicity of human melanosomes: An in vitro study
    Authors:
    Olchawa MM, Szewczyk GM, Zadlo AC, Krzysztynska-Kuleta OI, Sarna TJ
    Academic press:
    Pigment Cell & Melanoma Research (rok: 2020, tom: brak, strony: 45305), Wydawca: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ DENMARK
    Status:
    Published
    DOI:
    10.1111/pcmr.12914 - link to the publication

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