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Information on the principal investigator and host institution

Information of the project and the call

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Interplay between NF-kB and p53-dependent pathways in cellular response to DNA damaging factors.

2013/08/M/NZ1/00935

Keywords:

signalling pathways transcription factors DNA damage

Descriptors:

  • NZ1_1: Molecular biology
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_7: Bioinformatics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Oddział w Gliwicach

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Widłak 

Number of co-investigators in the project: 8

Call: HARMONIA 4 - announced on 2012-12-15

Amount awarded: 951 600 PLN

Project start date (Y-m-d): 2013-09-06

Project end date (Y-m-d): 2018-01-05

Project duration:: 52 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (1)
  1. Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes
    Authors:
    Janus P, Szołtysek K, Zając G, Walaszczyk A, Widłak W, Stokowy T, Wojtaś B, Gielniewski B, Iwanaszko M, Braun R, Cockell S, Perkins ND, Kimmel M, Widlak P
    Academic press:
    Cellular Signalling (rok: 2018, tom: 46, strony: 23-31), Wydawca: Elsevier Science Inc.
    Status:
    Published
    DOI:
    10.1016/j.cellsig.2018.02.011 - link to the publication
  2. Cross talk between cytokine and hyperthermia-induced pathways: identification of different subsets of NF-κB-dependent genes regulated by TNFα and heat shock
    Authors:
    Janus P, Stokowy T, Jaksik R, Szoltysek K, Handschuh L, Podkowinski J, Widlak W, Kimmel M, Widlak P
    Academic press:
    Molecular Genetics and Genomics (rok: 2015, tom: 290, strony: 1979-1990), Wydawca: Springer Heidelberg
    Status:
    Published
    DOI:
    10.1007/s00438-015-1055-1 - link to the publication
  3. Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-kappaB signaling
    Authors:
    Kardyńska M, Paszek A, Śmieja J, Spiller D, Widłak W, White MRH, Paszek P, Kimmel M
    Academic press:
    Plos Computational Biology (rok: 2018, tom: 14(4), strony: e.1006130), Wydawca: Public Library Science
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1006130 - link to the publication
  4. Irradiation with UV-C inhibits TNFα-dependent activation of the NF-κB pathway in a mechanism potentially mediated by reactive oxygen species
    Authors:
    Szołtysek K, Walaszczyk A, Janus P, Kimmel M, Widłak P
    Academic press:
    Genes to Cells (rok: 2017, tom: 22, strony: 45-58), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1111/gtc.12455 - link to the publication
  5. RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation
    Authors:
    Szołtysek K, Janus P, Zając G, Stokowy T, Walaszczyk A, Widłak W, Wojtaś B, Gielniewski B, Cockell S, Perkins ND, Kimmel M, Widlak P
    Academic press:
    BMC Genomics (rok: 2018, tom: 19(1), strony: e.813), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12864-018-5211-y - link to the publication
  1. Crosstalk between stress-induced NF-κB, p53 and HSF1 signaling pathways – review
    Authors:
    Widłak P, Gramatyka M, Kimmel M
    Conference:
    19th World Congress of the International Federation of Automatic Control (rok: 2014, ), Wydawca: International Federation of Automatic Control
    Data:
    konferencja 24-29.08.2014
    Status:
    Published

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