Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanisms of the conformational memory effect in induction of insulin amyloid strains

2012/07/B/NZ1/02642

Keywords:

amyloid kinetically-controlled proceses self-propagating polymorphism cross-seeding aggregated beta-sheet structure insulin analogs prion strains

Descriptors:

  • NZ1_3: Biophysics
  • NZ1_4: Structural biology
  • ST5_15:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Wysokich Ciśnień PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Wojciech Dzwolak 

Number of co-investigators in the project: 5

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 580 000 PLN

Project start date (Y-m-d): 2013-06-12

Project end date (Y-m-d): 2016-06-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Programowalne termostatowane wytrząsarki do eppendorfów typu "ThermoMixer" (48 000 PLN)
  2. Precyzyjna waga analityczna (8 000 PLN)
  3. Sonikator do białek (procesor ultradźwiękowy).
  4. Precyzyjny pH-metr z ultracienką elektrodą pH (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Master and Slave Relationship Between Two Types of Self-Propagating Insulin Amyloid Fibrils
    Authors:
    W. Surmacz-Chwedoruk, V. Babenko, W. Dzwolak
    Academic press:
    Journal of Physical Chemistry B (rok: 2014, tom: 118, strony: 13582–13589), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jp510980b - link to the publication
  2. Highly Amyloidogenic Two-chain Peptide Fragments Are Released upon Partial Digestion of Insulin with Pepsin
    Authors:
    M. Piejko, R. Dec, V. Babenko, A. Hoang, M. Szewczyk, P. Mak, W. Dzwolak
    Academic press:
    Journal of Biological Chemistry (rok: 2015, tom: 290, strony: 5947–5958), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M114.608844 - link to the publication
  3. The emergence of superstructural order in insulin amyloid fibrils upon multiple rounds of self-seeding
    Authors:
    W. Surmacz-Chwedoruk, V. Babenko, R. Dec, P. Szymczak, W. Dzwolak
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: 32022), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep32022 - link to the publication
  4. On the Heat Stability of Amyloid-Based Biological Activity: Insights from Thermal Degradation of Insulin Fibrils
    Authors:
    W. Surmacz-Chwedoruk, I. Malka, Ł. Bożycki, H. Nieznańska, W. Dzwolak
    Academic press:
    PLoS ONE (rok: 2014, tom: 9, strony: e86320), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0086320 - link to the publication

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