Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The influence of glucagon-like peptied-1 receptor agaonists on regulation of coticotropin-releasing hormone gene promoter activity

2012/07/N/NZ7/04394

Keywords:

glucagon-like peptide-1 exendin-4 corticotropin-releasing hormone promoter gene transfection forskolin glucocorticoids insulin mHypoA cells depression diabetes

Descriptors:

  • NZ3_7: Signal transduction
  • NZ4_8: Neuroendocrinology
  • NZ3_5: Molecular neurobiology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Jan Detka 

Number of co-investigators in the project: 3

Call: PRELUDIUM 4 - announced on 2012-09-15

Amount awarded: 148 200 PLN

Project start date (Y-m-d): 2013-07-04

Project end date (Y-m-d): 2017-04-03

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  1. Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line
    Authors:
    Jan Detka, Joanna Ślusarczyk, Anna Kurek, Mateusz Kucharczyk, Tomasz Adamus, Paweł Konieczny, Marta Kubera, Agnieszka Basta-Kaim, Władysław Lasoń, Bogusława Budziszewska
    Academic press:
    Pharmacological Reports , Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.pharep.2018.11.001 - link to the publication
  1. The influence of glucagon-like peptide-1 receptor agonists on corticotropin-releasing hormone promoter gene in a hypothalamic cell line
    Authors:
    Jan Detka, Joanna Ślusarczyk, Bogusława Budziszewska
    Conference:
    Neuronus IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus IBRO & IRUN Neuroscience Forum
    Data:
    konferencja 22-24 kwiecień
    Status:
    Published
  2. The effect of chronic hypothalamic-pituitary-adrenal axis activation on hypothalamic glucagon-like peptide-1 action in an animal model of depression and in vitro studies
    Authors:
    Jan Detka, Anna Kurek, Mateusz Kucharczyk, Joanna Ślusarczyk, Władysław Lasoń, Bogusława Budziszewska
    Conference:
    ECE 2017 19th European Congress of Endocrinology (rok: 2017, ), Wydawca: Endocrine Abstracts
    Data:
    konferencja 20-23 Maj
    Status:
    Published
    DOI:
    link to the publication

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