Interaction of a potential anticancer agent, 3-bromopyruvic acid, with normal and malignant cells
2012/07/B/NZ7/03618
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_15: Toksykologia
- NZ5_7: Leczenie chorób człowieka
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Rzeszowski, Wydział Biologiczno-Rolniczy
Voivodeship: podkarpackie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 4 – announced on 2012-09-15
- Amount awarded
- 476 800 PLN
- Project start date
- 2013-07-15
- Project end date
- 2016-07-14
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Inkubator CO2 z regulowanym dopływem tlenu. Cost: 70 000 PLN
- Mikroskop z odwróconą optyką. Cost: 30 000 PLN
Information in the final report
Publication in academic press/journals (5)
-
Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells
- Authors:
- Kwiatkowska E, Wojtala M, Gajewska A, Soszyński M, Bartosz G, Sadowska-Bartosz I.
- Academic press:
- Journal of Bioenergetics and Biomembranes (year: 2016, volume: 48, pages: 23-32), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s10863-015-9637-5 – link to the publication
-
Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione
- Authors:
- Sadowska-Bartosz I, Szewczyk R, Jaremko L, Jaremko M, Bartosz G.
- Academic press:
- Pharmacological Reports (year: 2016, volume: 68, pages: 502-505), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.pharep.2015.11.007 – link to the publication
-
ABCB1-overexpressing MDCK-II cells are hypersensitive to 3-bromopyruvic acid
- Authors:
- Sadowska-Bartosz I, Grębowski J, Kępka E, Studzian M, Bartosz G, Pulaski L
- Academic press:
- Life Sciences (year: 2016, volume: 162, pages: 138-144), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.lfs.2016.08.012 – link to the publication
-
Effect of 3-bromopyruvic acid on human erythrocyte antioxidant defense system
- Authors:
- Sadowska-Bartosz I, Bartosz G.
- Academic press:
- Cell Biology International (year: 2013, volume: 37, pages: 1285-1290), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1002/cbin.10160 – link to the publication
-
Transport of 3-bromopyruvate across the human erythrocyte membrane
- Authors:
- Sadowska-Bartosz I, Soszyński M, Ułaszewski S, Ko Y, Bartosz G.
- Academic press:
- Cellular and Molecular Biology Letters (year: 2014, volume: 19, pages: 201-214), Publisher: De Gruyter
- Status:
- Published
- DOI:
- 10.2478/s11658-014-0189-1 – link to the publication