Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Serum Response Factor (SRF) in the regulation of homeostatic plasticity.

2012/07/E/NZ3/01814

Keywords:

transcription factor - SRF epilepsy homeostatic plasticity spines

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_6: Cell neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Kalita-Bykowska 

Number of co-investigators in the project: 4

Call: SONATA BIS 2 - announced on 2012-09-15

Amount awarded: 1 500 000 PLN

Project start date (Y-m-d): 2013-06-24

Project end date (Y-m-d): 2019-06-23

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pompa perystaltyczna.
  2. Kamera CCD z oprogramowaniem (25 000 PLN)
  3. Komputer i dwa monitory.
  4. Maszyna PCR (15 000 PLN)
  5. Oprogramowanie do skaningowej stymulacji laserowej.
  6. Platforma pomiarowa Alcatraz (platforma pomiarowa, dwa mikromanipulatory z kontrolerem, stolik pod mikroskop oraz komora pomiarowa podgrzewana).
  7. Wzmacniacz (patch-clamp) (40 000 PLN)
  8. mikrowirówka (5 200 PLN)
  9. Karata akwizycyjna ze specjalistycznym oprogramowaniem (40 000 PLN)
  10. Karta akwizycyjna.
  11. Kontroler temperatury z grzałką przepływową oraz czujnikiem temperatury.
  12. Manipulatory precyzyjne (2 szt.) (50 000 PLN)
  13. Komputer (6 000 PLN)
  14. Manipulatory mechaniczne (2 szt.) (10 000 PLN)
  15. Mikrowirówka.
  16. Maszyna PCR.
  17. Oprogramowanie do akwizycji danych.
  18. Platforma pomiarowa (13 000 PLN)
  19. Pompa perystaltyczna (6 000 PLN)
  20. Stolik ruchomy pod mikroskop (10 000 PLN)
  21. Zestaw elementów optycznych do kontrastu DIC (producent Zeiss).

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. Adult Deletion of SRF Increases Epileptogenesis and Decreases Activity-Induced Gene Expression
    Authors:
    Kuzniewska B, Nader K, Dabrowski M, Kaczmarek L, Kalita K.
    Academic press:
    Molecular Neurobiology (rok: 2016, tom: 53, strony: 1478–1493), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-014-9089-7 - link to the publication
  2. Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology
    Authors:
    Kaneda M, Sakagami H, Hida Y, Ohtsuka T, Satou , Ishibashi Y, Fukuchi M, Krysiak A, Ishikawa M, Ihara D, Kalita K, Tabuchi A.
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 727), Wydawca: Nature.com
    Status:
    Published
    DOI:
    10.1038/s41598-017-18905-7 - link to the publication
  3. Loss of serum response factor in mature neurons in the dentate gyrus alters the morphology of dendritic spines and hippocampus-dependent behavioral tasks.
    Authors:
    Nader K, Krysiak A, Beroun A, Pekala M, Szymanska M, Kuzniewska B, Radwanska K, Kaczmarek L, Kalita K.
    Academic press:
    Brain structure and Function (rok: 2019, tom: 1, strony: 1), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00429-019-01925-6 - link to the publication
  4. c-Fos and neuronal plasticity: the aftermath of Kaczmarek's theory.
    Authors:
    Jaworski J, Kalita K, Knapska E.
    Academic press:
    Acta Neurobiol Exp (rok: 2018, tom: 78, strony: 287–296), Wydawca: Nencki Institute of Experimental Biology Polish Neuroscience Society
    Status:
    Published
    DOI:
    10.21307/ane‑2018‑027 - link to the publication
  1. Adult deletion of SRF regulates structural plasticity in neurons
    Authors:
    Nader K., Suska A., Krysiak A., Kaczmarek L., Kalita K
    Conference:
    5th Champalimaud Neuroscience Symposium (rok: 2016, ), Wydawca: Champalimaud Neuroscience Symposium
    Data:
    konferencja 21-24 września
    Status:
    Published
  2. Developmental loss of serum response factor (SRF) alters maturation of hippocampal neurons.
    Authors:
    A. Krysiak , L. Majchrowicz , A. Beroun , L. Kaczmarek, K. Kalita
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS
    Data:
    konferencja 6-11 July, Kraków
    Status:
    Published
  3. Serum Response Factor (SRF) regulates structural plasticity of dendritic spines during development.
    Authors:
    Katarzyna Kalita, Anna Krysiak, Anna Suska, Szymon Leski and Leszek Kaczmarek
    Conference:
    SFN 2016, SanDiego (rok: 2016, ), Wydawca: SFN
    Data:
    konferencja November 12-16
    Status:
    Published
  4. Transcription factor SRF controls neuronal plasticity
    Authors:
    Katarzyna Kalita
    Conference:
    13 TH INTERNATIONAL CONGRESS OF POLISH NEUROSCIENCE SOCIETY (rok: 2017, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja August 28th-31
    Status:
    Published